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9780198523604

Ion Channel Pharmacology

by ;
  • ISBN13:

    9780198523604

  • ISBN10:

    0198523602

  • Format: Hardcover
  • Copyright: 1998-05-14
  • Publisher: Oxford University Press

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Summary

Molecular biology techniques have led to increased understanding of ion channel structure which has opened the way for the development of new drugs targeted at specific types of ion channels. This book aims to provide a fully comprehensive, single-volume overview of the effects of differentdrugs and toxins on ionic channels, with every chapter providing a detailed description of the pharmacology of each particular ion channel. It will be an essential reference tool for all researchers in this topical and fast-moving subject area.

Table of Contents

Contributors ix
PART ONE DEVELOPMENT 3(20)
1 Neurotrophic factors and development of ionic channels in primary sensory neurones of the ear
3(20)
F. Garcia-Diaz
C. Jimenez
E. Vazquez
J. Represa
F. Giraldez
PART TWO SODIUM CHANNELS 23(74)
2 Chemical modulation of sodium channels
23(51)
T. Narahashi
3 Antiarrhythmic action of drugs interacting with sodium channels
74(23)
J. Tamargo
E. Delpon
O. Perez
C. Valenzuela
PART THREE CALCIUM CHANNELS 97(70)
4 Biophysics of voltage-dependent Ca(2+) channels: gating kinetics and their modulation
97(32)
E. Carbone
V. Magnelli
A. Pollo
V. Carabelli
A. Albillos
H. Zucker
5 Pharmacology of voltage-dependent calcium channels
129(20)
B.P. Bean
I.M. Mintz
L.M. Boland
D.W.Y. Sah
J.A. Morrill
6 Ion channels formed by amyloid Beta protein (A Beta P[1-40]). Pharmacology and therapeutic implications for Alzheimer's disease
149(18)
H.B. Pollard
N. Arispe
E. Rojas
PART FOUR POTASSIUM CHANNELS 167(80)
7 The biophysical basis of K(+) channel pharmacology
167(19)
B. Soria
8 Peptide toxins interacting with potassium channels
186(22)
M.L. Garcia
H.-G. Knaus
R.J. Leonard
O.B. McManus
P. Munujos
W.A. Schmalofer
R.S. Slaughter
G.J. Kaczorowski
9 Properties of the ATP-regulated K(+) channel in pancreatic Beta-cells
208(21)
M.J. Dunne
10 Potential role of the pharmacology of K(+) channels in therapeutics
229(18)
B. Soria
PART FIVE CHLORIDE CHANNELS 247(24)
11 Chloride channel pharmacology
247(24)
M.A. Valverde
S.P. Hardy
A.S. Monaghan
PART SIX MECHANO-GATED CHANNELS 271(10)
12 Drug effects on mechano-gated channels
271(10)
O.P. Hamill
D.W. McBride, Jr.
PART SEVEN INTRACELLULAR CHANNELS 281(102)
13 Intracellular channels in muscle
281(18)
E. Jaimovich
14 Basic properties of calcium release channels in neural cells
299(22)
P. Kostyuk
A. Verkhratsky
15 Mitochondrial membrane channels and their pharmacology
321(22)
M.-L. Campo
H. Tedeschi
C. Muro
K.W. Kinnally
16 Modulation of a large-conductance K(+) channel from chromaffin granule membranes by adrenergic agonists and G proteins
343(40)
N. Arispe
P.De Mazancourt
H.B. Pollard
E. Rojas
PART EIGHT CYCLIC NUCLEOTIDE-GATED CHANNELS 383(16)
17 Cyclic nucleotide-gated ion channels: physiology, pharmacology, and molecular biology
383(16)
G. Matthews
PART NINE RECEPTOR-OPERATED CHANNELS 399(70)
18 Excitatory amino acid-activated channels
399(23)
J. Lerma
A.V. Paternain
N. Salvador
F. Somohano
M. Morales
M. Casado
19 Comparison of native and recombinant NMDA receptor channels
422(16)
P. Stern
D. Colquhoun
20 A unified theory of antidepressant action: evidence for adaptation of the NMDA receptor following chronic antidepressant treatments
438(19)
R.T. Layer
P. Popik
G. Nowak
I.A. Paul
R. Trullas
P. Skolnick
21 Excitatory synaptic transmission in hippocampus: modulation by purinoceptors via Ca(2+) channels
457(12)
O. Krishtal
A. Klishin
Index 469

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