The Society of Cells: Cancer and Control of Cell Proliferation

by Sonnenschein, Carlos; Soto, A. M.

• ISBN13: 9780387915838
• ISBN10: 0387915834
• Edition: 1st
• Format: Paperback
• Copyright: 1999-05-01
• Publisher: Springer Verlag

Summary

(BIOS Scientific Publisher) Tufts Univ., Boston, MA. Reviews the concepts and theories that guide research on the control of cell proliferation and cancer, and asks the question 'What is the nature of the default state of all cells - quiescence or proliferation?' Proposes the adoption new premises of exploration in this area. For researchers. Softcover.

Table of Contents

Abbreviations	viii
Preface	ix
Acknowledgements	xiii
PART 1
Cell proliferation: the background and the premises	1	(13)
Introduction	1	(1)
A brief history	2	(5)
Understanding the control of cell proliferation	7	(2)
The hierarchical organization of nature	9	(2)
Conclusions	11	(1)
References	12	(2)
Cell proliferation, cell nutrition and evolution	14	(17)
Evolutionary perspective on the control of cell proliferation	14	(6)
The role of nutrition on the control of cell proliferation	20	(6)
Conclusions	26	(1)
References	27	(4)
The experimental evaluation of cell proliferation	31	(10)
Introduction	31	(6)
Fitting data into working hypotheses	37	(1)
The use and misuse of tritiated thymidine incorporation data	38	(1)
Conclusions	39	(1)
References	40	(1)
Hypotheses for the control of cell proliferation	41	(19)
Historical perspective	41	(4)
Positive hypotheses	45	(7)
Negative hypotheses	52	(3)
Conclusions	55	(1)
References	55	(5)
Sex hormone-mediated control of cell proliferation	60	(18)
Introduction	60	(1)
Control of cell proliferation by estrogens	61	(1)
Hypotheses	62	(9)
Control of cell proliferation by androgens	71	(1)
Conclusions	72	(2)
References	74	(4)
Cell proliferation and tissue differentiation	78	(13)
The different meanings of `differentiation'	78	(1)
A hierarchical perspective	79	(1)
The elusive concept of stem cells	80	(1)
The hemopoietic stem cells	81	(3)
Proliferation of antibody-producing cells: a different perspective	84	(2)
Conclusions	86	(2)
References	88	(3)
PART 2
Introduction to carcinogenesis and neoplasia	91	(8)
If normal cells beget normal cells, and neoplastic cells beget neoplastic cells, what causes normal cells to become neoplastic?	93	(2)
Germ-line mutations and carcinogenesis	95	(1)
Somatic mutations, cell proliferation, cell death, and the `differentiation' hypotheses	96	(1)
Are carcinogenesis and neoplasia cellular or tissue-based phenomena?	97	(1)
References	98	(1)
The enormous complexity of cancer	99	(13)
Introduction	99	(2)
Hierarchical levels of complexity in cancer	101	(7)
Conclusions	108	(1)
References	109	(3)
Facts and fantasies in carcinogenesis	112	(22)
Introduction	112	(6)
Experimental carcinogenesis: the lessons missed	118	(1)
Foreign-body carcinogenesis	118	(2)
Physical carcinogenesis	120	(1)
Chemical carcinogenesis	120	(2)
Viral carcinogenesis. But . . . are viruses per se carcinogenic agents?	122	(3)
On the uniqueness of the neoplastic cell	125	(2)
Carcinogenesis in a flask	127	(1)
Conclusions	128	(2)
References	130	(4)
Epilogue. Moving toward the integration of cell proliferation, carcinogenesis, and neoplasia into biology	134	(11)
Ideology, silent assumptions, and operational definitions	135	(2)
The universality of proliferation as the default state of all cells	137	(2)
Forerunners of the tissue organization field hypothesis	139	(1)
On paradigm changes	139	(1)
An integrative approach of control of cell proliferation and carcinogenesis	140	(2)
The impact of our reassessment	142	(1)
And . . . finally	142	(1)
References	143	(2)
Index	145