Written by a leading expert on Aspirin-related research, this is the first comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever.The text is written with a wide audience in mind and to be readily understandable for clinicians as well as biomedical researchers and pharmacologists alike. The content is up to date and includes the latest results of clinical and academic research, with a balanced view on the disputed properties of this famous drug. Key Features: A must-have for everyone working with Aspirin. An invaluable compendium for clinicians and biomedical researchers on one of the most successful drugs in history. Written by one of the leading experts on the drug with more than 350 publications. First comprehensive treaty of the history, pharmacological effects and clinical applications of this famous drug.

Prof. Karsten Schror, MD
Institut fur Pharmakologie und Klinische Pharmakologie
Heinrich-Heine-Universitat
Dusseldorf

CURRICULUM VITAE (May, 2008)

Date of birth: May 3, 1942

Place of birth: Oldenburg

Marital status: married

Education:
1961 - 1967 Medicine, Universitat Halle/Wittenberg
1967 - 1972 Pharmacology, Universitat Halle/Wittenberg

MD Thesis: Effects of variations in external Ca++- and K+-concentrations on sympathetic nerve stimulation (Department of Physiology, Universitat Halle/Wittenberg, 1970)

Wellcome Research Laboratories (UK); Supervisor: Sir John R. Vane, 1976 - 1977; Department of Physiology, Jefferson Medical College, Philadelphia (USA); Supervisor: Prof. A.M. Lefer, 1977; Visiting Professor at the Medical University of South Carolina at Charleston (USA) (Prof. P.V. Halushka), 1993 - 1994; Visiting Professor at the Department of Internal Medicine, Division of Hematology

Preface	p. XI
General Aspects	p. 3
History	p. 5
Willow Bark and Leaves as Antipyretic, Anti-Inflammatory Analgesics	p. 5
Salicylates as the Active Ingredient of Willow Bark and Other Natural Sources	p. 6
Synthesis of Acetylsalicylic Acid and First Clinical Studies	p. 7
Mode of Aspirin Action	p. 12
Anti-Inflammatory/Analgesic Actions of Aspirin	p. 14
Aspirin in the Cardiovascular System	p. 15
Current Research Topics	p. 17
Chemistry	p. 25
Structures and Chemical Properties of Salicylates	p. 25
Salicylates in Clinical Use	p. 25
Aspirin Formulations	p. 27
Determination of Salicylates	p. 30
Gas-Liquid Chromatography	p. 30
High-Performance Liquid Chromatography	p. 30
Spectrophotometry	p. 30
Pharmacology	p. 33
Pharmacokinetics	p. 35
Absorption and Distribution	p. 36
Absorption	p. 36
Particular Aspirin Formulations	p. 40
Distribution	p. 40
Modifying Factors	p. 42
Biotransformation and Excretion	p. 46
Biotransformation of Aspirin	p. 46
Biotransformations of Salicylic Acid	p. 48
Excretion of Salicylates	p. 49
Modification of Biotransformations and Excretion of Salicylates	p. 50
Cellular Modes of Action	p. 53
Inhibition of Cyclooxygenases	p. 54
Acetylation of Cyclooxygenases and Traditional NSAIDs	p. 55
Modulation of COX-2 Gene Expression	p. 61
Further Actions of Salicylates on Arachidonate Metabolism	p. 62
COX-Independent Actions on Cell Function	p. 66
Kinases	p. 67
Transcription Factors	p. 69
Oxidative Stress and Nitric Oxide	p. 73
Immune Responses	p. 75
Energy Metabolism	p. 79
Fatty Acid ß-Oxidation	p. 80
Uncoupling of Oxidative Phosphorylation	p. 82
Toxic Actions of Salicylates on the Liver	p. 84
Actions on Organs and Tissues	p. 88
Hemostasis and Thrombosis	p. 89
Platelets	p. 90
Endothelial Cells	p. 95
Plasmatic Coagulation	p. 98
Fibrinolysis	p. 98
Inflammation, Pain, and Fever	p. 105
Inflammation	p. 106
Pain	p. 110
Fever	p. 113
Aspirin and Malignancies	p. 120
COX-Related Antitumor Effects of Aspirin	p. 120
Nonprostaglandin-Related Antitumor Actions of Aspirin	p. 122
Nonspecific Actions of Salicylates	p. 124
Toxicity and Drug Safety	p. 129
Systemic Side Effects	p. 131
Acute and Chronic Toxicity	p. 132
Occurrence and Symptoms	p. 132
Treatment	p. 136
Habituation	p. 139
Bleeding Disorders	p. 142
Prolongation of Bleeding Time by Aspirin	p. 142
Aspirin-Related Bleeding Risk in Surgical Interventions	p. 144
Aspirin, Other Drugs, and Alcohol	p. 146
Prevention and Treatment of Bleedings	p. 146
Safety Pharmacology in Particular Life Situations	p. 150
Pregnancy and Fetal Development	p. 150
The Elderly Patient	p. 153
Organ Toxicity	p. 157
Gastrointestinal Tract	p. 157
Pathophysiology of GI Injury	p. 158
Prostaglandins and Gastric Mucosal Protection	p. 160
Mode of Aspirin Action	p. 161
Helicobacter pylori	p. 164
Clinical Studies	p. 166
Aspirin and Other Drugs	p. 170
Kidney	p. 179
Analgesic Nephropathy	p. 179
Mode of Aspirin Action	p. 180
Clinical Studies	p. 181
Liver	p. 187
Drug-Induced Liver Injury	p. 187
Mechanisms of Aspirin Action	p. 187
Aspirin and Other Drugs	p. 188
Audiovestibular System	p. 191
Pathophysiology of Hearing and Equilibrium Disturbances	p. 191
Mode of Aspirin Action	p. 191
Aspirin, Arachidonic Acid, and Prostaglandins	p. 193
Clinical Trials	p. 193
Non-Dose-Related (Pseudo)allergic Actions of Aspirin	p. 197
Aspirin Hypersensitivity (Widal's Syndrome)	p. 197
Pathophysiology and Clinics	p. 197
Mode of Aspirin Action	p. 199
Clinical Trials	p. 201
Urticaria/Angioedema, Stevens-Johnson and Lyell Syndromes	p. 205
Urticaria/Angioedema	p. 205
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (Lyell Syndrome)	p. 206
Reye's Syndrome	p. 208
Clinics, Laboratory, and Morphological Findings	p. 209
Etiology	p. 209
Clinical Studies	p. 212
Actual Situation	p. 217
Clinical Applications of Aspirin	p. 223
Thromboembolic Diseases	p. 227
Coronary Vascular Disease	p. 228
Thrombotic Risk and Mode of Aspirin Action	p. 229
Clinical Trials: Primary Prevention in Individuals Without Risk Factors	p. 231
Clinical Trials: Primary Prevention in Individuals with Risk Factors	p. 235
Clinical Trials: Stable Angina Pectoris	p. 237
Clinical Trials: Secondary Prevention	p. 238
Clinical Trials: Percutaneous Coronary Interventions	p. 243
Clinical Trials: Coronary Artery Bypass Graft Surgery (CABG)	p. 244
Aspirin and Other Drugs	p. 246
Actual Situation	p. 250
Cerebrovascular Diseases	p. 260
Thrombotic Risk and Mode of Aspirin Action	p. 261
Clinical Trials: Primary Prevention	p. 263
Clinical Trials: Secondary Prevention	p. 265
Aspirin and Other Drugs	p. 267
Actual Situation	p. 270
Peripheral Arterial Disease	p. 276
Thrombotic Risk and Mode of Aspirin Action	p. 276
Clinical Trials: Primary Prevention	p. 278
Clinical Trials: Secondary Prevention	p. 279
Clinical Trials: Peripheral Transluminal Angioplasty (PTA)	p. 281
Aspirin and Other Drugs	p. 282
Actual Situation	p. 283
Venous Thrombosis	p. 287
Thrombotic Risk and Mode of Aspirin Action	p. 287
Clinical Trials	p. 287
Actual Situation	p. 288
Preeclampsia	p. 290
Thrombotic Risk and Mode of Aspirin Action	p. 290
Clinical Trials	p. 293
Clinical Trials in Pregnancy-Induced Hypertension: Reasons for Data Variability	p. 294
Actual Situation	p. 298
Aspirin "Resistance"	p. 303
Definition and Types of Pharmacological Aspirin "Resistance"	p. 304
Detection of Aspirin "Resistance"	p. 304
Pharmacological Mechanisms of Aspirin "Resistance"	p. 307
Clinical Trials	p. 310
Pain, Fever, and Inflammatory Diseases	p. 322
Aspirin as an Antipyretic Analgesic	p. 322
Fever, Pain, and Antipyretic/Analgesic Actions of Aspirin	p. 323
Clinical Trials	p. 326
Aspirin and Other Drugs	p. 327
Actual Situation	p. 328
Arthritis and Rheumatism	p. 332
Pathophysiology and Mode of Aspirin Action	p. 332
Clinical Trials	p. 334
Aspirin and Other Drugs	p. 335
Actual Situation	p. 336
Kawasaki Disease	p. 339
Pathophysiology and Mode of Aspirin Action	p. 339
Clinical Trials	p. 340
Aspirin and Other Drugs	p. 341
Actual Situation	p. 341
Further Clinical Indications	p. 343
Colorectal Cancer	p. 343
Etiology and Pathophysiology of Intestinal Adenomas, Colorectal Cancer, and Mode of Aspirin Action	p. 344
Clinical Trials: Epidemiological Studies	p. 346
Clinical Trials: Randomized Prospective Prevention Trials	p. 349
Aspirin and Other Drugs	p. 352
Actual Situation	p. 352
Alzheimer's Disease	p. 359
Pathophysiology and Mode of Aspirin Action	p. 359
Clinical Trials	p. 361
Aspirin and Other Drugs	p. 363
Actual Situation	p. 363
	p. 367
	p. 369
Index	p. 371
Table of Contents provided by Ingram. All Rights Reserved.

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