Acute Liver Failure

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  • Edition: Revised
  • Format: Paperback
  • Copyright: 2011-06-02
  • Publisher: Cambridge University Press
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Acute liver failure (ALF), or fulminant hepatic failure, is a distinct clinical syndrome that crosses medical disciplines. A relatively rare condition, ALF remains a major focus of clinical and research attention. With the advent of transplantation, the importance of understanding management of ALF has taken on a new urgency. In this first volume dedicated to ALF, the editors bring together a distinguished team of contributors to describe the etiology, pathology and treatment of this important syndrome. Also covered are consensus techniques in liver transplantation for ALF patients, as well as descriptions of artificial and bioartificial liver assist devices. A section on future treatments includes hepatocyte transplantation, auxiliary grafts and other temporary liver support. Notable for the high level of the authors' expertise, this comprehensive volume should prove invaluable.

Table of Contents

Clinical Syndrome and Etiology:
Classification and clinical syndromes of Acute Liver Failure
Viral hepatitis and Acute Liver Failure
Drug hepatoxicity and Acute Liver Failure
Acetaminophen-related Acute Liver Failure
Unusual causes of Acute Liver Failure
Pediatric aspects of Acute Liver Failure
Mechanisms of Disease and Multisystem Involvement:
The role of cytokines and immune mechanisms in Acute Liver Failure
The pathology of Acute Liver Failure
Hepatic replication and liver regeneration
Intensive Care Management
Medical management of Acute Liver Failure
Circulatory derangements: monitoring and management of heart, kidney and brain
Brain edema and intracranial hypertension in Acute Liver Failure
Management of infection in Acute Liver Failure
Prognosis and consideration of transplantation
Liver transplantation in patients with Acute Liver Failure: the European experience
Liver transplantation in patients with Acute Liver Failure: the American experience
Auxiliary liver transplantation
Artificial and Bioartifical Liver Devices:
Extracorporeal liver support: historical background and critical analysis
Hepatocyte culture and bioreactor design for liver support systems
Clinical experience with an extracorporeal liver assist device (ELAD)
Other Approaches:
Treatment of Acute Liver Failure by high volume plasmapheresis
Dialysis/adsorption techniques for Acute Liver Failure
Hepatocyte transplantation in liver failure and inherited metabolic disorders
Table of Contents provided by Publisher. All Rights Reserved.

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