Acute Liver Failure

by Edited by William M. Lee , Roger Williams , Foreword by Jean-Pierre Benhamou , Jacques Bernuau

• ISBN13: 9780521553810
• ISBN10: 0521553814
• Format: Hardcover
• Copyright: 1996-12-28
• Publisher: Cambridge University Press

Summary

Acute liver failure (ALF), or fulminant hepatic failure, is a distinct clinical syndrome which crosses medical disciplines. A relatively rare condition, ALF remains a major focus of clinical and research attention and with the advent of transplantation, the importance of understanding management of ALF has taken on a new urgency. In the first volume dedicated to ALF, the editors bring together a distinguished team of contributors to describe the aetiology, pathology and treatment of this important syndrome. Also covered are consensus techniques in liver transplantation for ALF patients, as well as descriptions of artificial and bioartificial liver assist devices. A section on future treatments includes hepatocyte transplantation, auxiliary grafts and other temporary liver support. Notable for the high level of authors' expertise, this comprehensive volume should prove invaluable to internists, gastroenterologists, surgeons, and intensive care providers.

Table of Contents

Part I. Clinical Syndrome and Etiology: 1. Classification and clinical syndromes of Acute Liver Failure

2. Viral hepatitis and Acute Liver Failure

3. Drug hepatoxicity and Acute Liver Failure

4. Acetaminophen-related Acute Liver Failure

5. Unusual causes of Acute Liver Failure

6. Pediatric aspects of Acute Liver Failure

Part II. Mechanisms of Disease and Multisystem Involvement: 7. The role of cytokines and immune mechanisms in Acute Liver Failure

8. The pathology of Acute Liver Failure

9. Hepatic replication and liver regeneration

Part III. Intensive Care Management

10. Medical management of Acute Liver Failure

11. Circulatory derangements: monitoring and management of heart, kidney and brain

12. Brain edema and intracranial hypertension in Acute Liver Failure

13. Management of infection in Acute Liver Failure

Part IV. Transplantation: 14. Prognosis and consideration of transplantation

15. Liver transplantation in patients with Acute Liver Failure: the European experience

16. Liver transplantation in patients with Acute Liver Failure: the American experience

17. Auxiliary liver transplantation

Part V. Artificial and Bioartifical Liver Devices: 18. Extracorporeal liver support: historical background and critical analysis

19. Hepatocyte culture and bioreactor design for liver support systems

20. Clinical experience with an extracorporeal liver assist device (ELAD)

Part VI. Other Approaches: 21. Treatment of Acute Liver Failure by high volume plasmapheresis

22. Dialysis/adsorption techniques for Acute Liver Failure

23. Hepatocyte transplantation in liver failure and inherited metabolic disorders.