Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management

by Edited by Ulf Dieckmann , Johan A. J. Metz , Maurice W. Sabelis , Karl Sigmund

• ISBN13: 9780521022132
• ISBN10: 0521022134
• Format: Paperback
• Copyright: 2005-11-03
• Publisher: Cambridge University Press

Summary

Emerging diseases pose a continual threat to public health. Short multiplication time and high variability allow pathogens to evolve very rapidly. It is therefore imperative to incorporate evolutionary considerations into longer-term health management plans. The evolution of infectious disease is also an ideal test-bed for theories of evolutionary dynamics. This book combines both threads, taking stock of our current knowledge on the evolutionary ecology of infectious diseases, and setting out the goals for the management of virulent pathogens. Throughout the book, the fundamental concepts and techniques underlying the modelling are carefully explained in a unique series of integrated boxes. The book ends with an overview of novel options for virulence management in humans, farm animals, plants, wildlife populations and biological control schemes. Written for graduate students and researchers, Adaptive Dynamics of Infectious Diseases provides an integrated treatment of mathematical evolutionary modelling and disease management.

Table of Contents

1. Introduction Karl Sigmund, Maurice W. Sabelis, Ulf Dieckmann and J. A. J. Metz

Part I. Setting the Stage: 2. Alternative transmission modes and the evolution of virulence Paul W. Ewald and Guilio De Leo

3. Wildlife perspectives on the evolution of virulence Guilio De Leo, Andy Dobson and Andy Goodman

4. Adaptive dynamics of pathogen-host interactions Ulf Dieckmann

5. Dilemmas in virulence management Minus van Baalen

Part II. Host Population Structure: 6. Variation in susceptibility: lessons from an insect virus Greg Dwyer, Jonathan Dushoff, Joseph S. Elkinton, John P. Burand and Simon A. Levin

7. Contact networks and the evolution of virulence Minus van Baalen

8. Virulence on the edge: a source-sink perspective Robert D. Holt and Michael E. Hochberg

Part III. Within-Host Interactions: 9. Super- and coinfection: the two extremes Martin Nowak and Karl Sigmund

10. Super- and coinfection: filling the range Frederick Adler and Julio Mosquero Losada

11. Multiple infection and its consequences for virulence management Sylvain Gandon and Yannis Michalakis

12. Kin selection models as evolutionary explanations of malaria Andrew F. Read, Margaret J. Mackinnon, M. Ali Anwar and Louise H. Taylor

Part IV. Pathogen-Host Coevolution: 13. Coevolution of virus and host cell death signals David C. Krakauer

14. Biogeographical perspectives on arms races Michael E. Hochberg and Robert D. Holt

15. Major histocompatability complex: polymorphism from coevolution Joost B. Beltman, José

A. M. Borghans and Rob J. de Boer

16. Virulence management and disease resistance in diploid hosts Viggo Andreasen

17. Coevolution in gene-for-gene systems Akira Sasaki

18. Implications of sexual selection for virulence management Claus Wedekind

19. Molecular phylogenies and virulence evolution Bruce Rannala

Part V. Multilevel Selection: 20. Weakened from within: intragenomic conflict and virulence Rolf F. Hoekstra and Alfons J. M. Debets

21. Ecology and evolution of Chestnut Blight Fungus Douglas R. Taylor

22. Evolution of exploitation and defense in tritrophic interactions Maurice W. Sabelis, Minus van Baalen, Bas Pels, Martijn Egas and Arne Janssen

Part VI. Vaccines and Drugs: 23. Managing antibiotic resistance Sebastian Bonhoeffer

24. Evolution of vaccine-resistant strains of infectious agents Angela McLean

25. Pathogen evolution: the case of malaria Sunetra Gupta

26. Vaccination and serotype replacement Marc Lipsitch

Part VII. Perspectives for Virulence Management: 27. Taking stock: relating theory to experiment Maurice W. Sabelis and Johan A. J. Metz

28. Virulence management in humans Paul W. Ewald

29. Virulence management in wildlife populations Guilio De Leo and Andy Dobson

30. Virulence management in veterinary epidemiology Mart C. M. de Jong and Luc L. G. Janss

31. Virulence management in plant-pathogen interactions Andrew M. Jarosz

32. Management of virulence in biocontrol agents Sam L. Elliot, Maurice W. Sabelis and Frederick R. Adler

33. Epilogue Ulf Dieckmann, Karl Sigmund, Maurice W. Sabelis and Johan A. J. Metz.