Adhesion Molecules: Function and Inhibition

by Ley, Klaus

• ISBN13: 9783764379742
• ISBN10: 376437974X
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-10-01
• Publisher: BIRKHAUSER BOSTON INC

Summary

Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.

Table of Contents

List of contributors	p. vii
Preface	p. xi
Capture and rolling
P-selectin glycoprotein ligand-1 (PSGL-1)	p. 3
L-selectin-mediated leukocyte adhesion and migration	p. 27
P-and E-selectin	p. 71
Firm adhesion
Endothelial ICAM-1 functions in adhesion and signaling during leukocyte recruitment	p. 99
[alpha]4-integrins: structure, function and secrets	p. 117
VCAM-1 and its functions in development and inflammatory diseases	p. 141
Lymphocyte function-associated antigen-1 (LFA-1) and macrophage antigen-1 (Mac-1): Cooperative partners in leukocyte emigration and function	p. 175
Transendothelial migration
PECAM: Regulating the start of diapedesis	p. 201
Role of [alpha]6[beta]1 integrin in leukocyte adhesion and transmigration	p. 221
Vascular adhesion protein-1 (VAP-1)	p. 237
The role of endothelial cell-selective adhesion molecule (ESAM) in neutrophil emigration into inflamed tissues	p. 253
Structure and function of JAM proteins	p. 271
Promises and limitations of targeting adhesion molecules for therapy	p. 289
Index	p. 305
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