Adrenaline And the Inner World

by Goldstein, David S.

• ISBN13: 9780801882890
• ISBN10: 0801882893
• Edition: 1st
• Format: Paperback
• Copyright: 2006-02-01
• Publisher: JOHNS HOPKINS UNIV PRESS

Summary

This accessible work is the first in more than seventy-five years to discuss the many roles of adrenaline in regulating the "inner world" of the body. David S. Goldstein, an international authority and award-winning teacher, introduces new concepts concerning the nature of stress and distress across the body's regulatory systems. Discussing how the body's stress systems are coordinated, and how stress, by means of adrenaline, may affect the development, manifestations, and outcomes of chronic diseases, Goldstein challenges researchers and clinicians to use scientific integrative medicine to develop new ways to treat, prevent, and palliate disease. Goldstein explains why a former attorney general with Parkinson disease has a tendency to faint, why young astronauts in excellent physical shape cannot stand up when reexposed to earth's gravity, why professional football players can collapse and die of heat shock during summer training camp, and why baseball players spit so much. Adrenaline and the Inner World is designed to supplement academic coursework in psychology, psychiatry, endocrinology, cardiology, complementary and alternative medicine, physiology, and biochemistry. An extensive glossary is a fine adjunct to support the diversity and scope of its content.

Author Biography

David S. Goldstein, M.D., Ph.D., is an attending physician at the Clinical Center, National Institutes of Health, and a senior investigator at the National Institute of Neurological Disorders and Stroke.

Table of Contents

Preface	ix
1. The Inner World	1	(29)
The Seed and the Soil	4	(1)
Cannon's Canons	5	(3)
The Comfort Level in Building 10	8	(4)
An Amazing Cooking Experiment	12	(2)
Death by Football	14	(2)
The Sleeper Hold	16	(2)
Snakes That Faint?	18	(3)
Rules of the Game	21	(6)
Same Difference	27	(2)
The All-Day Sucker	29	(1)
2. The "Automatic Nervous System"	30	(27)
Transformers	35	(1)
Vegging	35	(5)
Good Housekeeping	40	(5)
The Hot Line	45	(1)
How Does the Autonomic Nervous System Work?	45	(12)
3. The Arbiters of the Inner World	57	(49)
The Fat above the Kidneys	57	(1)
On The Risk of Being a Physician's Son	58	(1)
What's in a Name?	59	(3)
Catecholamines Look Like Cats	62	(2)
Adrenaline's Effects on the Body	64	(15)
Neuronal Soda Pop	79	(12)
The Getaway Car Analogy	91	(2)
The Atavistic Catecholamine	93	(2)
"First I Secreted a Hell of a Lot of Adrenaline"	95	(6)
A Play-Doh Model of the Brain	101	(2)
The Nobel Chemicals	103	(3)
4. The Rest of the Cast	106	(15)
The Axis Powers	107	(3)
The Water Works and Kosher Pickle Treatment	110	(3)
Salt Sense	113	(2)
Your Own Brand of Morphine	115	(2)
Cytokines	117	(1)
Sex	118	(1)
Leptin	119	(2)
5. Stress as a Scientific Idea	121	(20)
A Brief History of Stress	121	(8)
Stress Response Patterns	129	(12)
6. Distress	141	(23)
Characteristics of Distress	141	(7)
Biblical Lie Detection	148	(2)
Distress versus the General Adaptation Syndrome	150	(1)
Fight Isn't Flight	151	(7)
The Nose of God	158	(2)
StressToons	160	(4)
7. Stress in Evolutionary Perspective	164	(17)
Why Evolution Is a Worthwhile Theory and Creationism Isn't	164	(5)
Darwin and Ethology	169	(3)
The Price of Complexity Is Eternal Stress	172	(4)
Primitive Specificity	176	(5)
8. Dysautonomias	181	(26)
The "Mind-Body" Problem	182	(2)
Primary versus Secondary Dysautonomias	184	(1)
Secondary Dysautonomias	185	(9)
Primary Dysautonomias	194	(13)
9. Tests for Dysautonomias	207	(17)
Physiological Tests	209	(6)
Neuropharmacological Tests	215	(5)
Neurochemical Tests	220	(2)
Neuroimaging Tests	222	(2)
10. Treatments for Dysautonomias	224	(11)
Nondrug Treatments	224	(5)
Drug Treatments	229	(6)
11. Drugs and the Family	235	(12)
Catecholamines as Drugs	235	(1)
Legal Addictions	236	(4)
Cocaine	240	(1)
Speed Kills	240	(2)
Morphine	242	(1)
Barbs and Benzos	242	(1)
You Aren't What You Eat, Luckily	243	(4)
12. The Future: Scientific Integrative Medicine	247	(22)
Return of the Getaway Car	248	(2)
Allostatic Load for People Who Hate Snakes	250	(4)
The Dialectic	254	(5)
Darwinian Medicine	259	(4)
Tactics and Strategies of Scientific Integrative Medicine	263	(3)
What, How, and Why	266	(3)
Conclusion	269	(2)
Glossary	271	(22)
References	293	(2)
Index	295