Adult Neurogenesis

by Gage, Fred H.

• ISBN13: 9780879697846
• ISBN10: 0879697849
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-11-15
• Publisher: Cold Spring Harbor Laboratory Press

Summary

The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesisincludes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.

Table of Contents

Preface	p. xi
Adult Neurogenesis: A Prologue	p. 1
Methods
In vivo approaches
Numerology of Neurogenesis: Characterizing the Cell Cycle of Neurostem Cells	p. 7
Detection and Phenotypic Characterization of Adult Neurogenesis	p. 25
Evolving Methods for the Labeling and Mutation of Postnatal Neuronal Precursor Cells: A Critical Review	p. 49
The Use of Reporter Mouse Lines to Study Adult Neurogenesis	p. 81
Retrovirus-mediated Cell Labeling	p. 101
In vitro approaches
Neurospheres	p. 119
Monolayer Cultures of Neural Stem/Progenitor Cells	p. 135
Basic Processes
Neurogenesis in the Adult Hippocampus	p. 159
Adult Subventricular Zone and Olfactory Bulb Neurogenesis	p. 175
Neurogenic Niches in the Adult Mammalian Brain	p. 207
Molecular and Physiological Mechanisms
Adult Neurogenesis: Similarities and Differences in Stem Cell Fate, Proliferation, Migration, and Differentiation in Distinct Forebrain Regions	p. 227
Proneuronal Genes Drive Neurogenesis on the Road from Development to Adulthood	p. 267
The Balance of Trophic Support and Cell Death in Adult Neurogenesis	p. 283
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus	p. 299
Regulation
Genetics and Epigenetics in Adult Neurogenesis	p. 321
Activity Dependency and Aging in the Regulation of Adult Neurogenesis	p. 341
Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammation	p. 363
Regulation of Adult Neurogenesis by Neurotransmitters	p. 397
Functional Significance
Adult Neurogenesis in the Olfactory Bulb	p. 425
Neurogenesis and Hippocampal Memory System	p. 445
Computational Modeling of Adult Neurogenesis	p. 463
Neurological Diseases
Hippocampal Neurogenesis: Depression and Antidepressant Response	p. 483
Adult Neurogenesis in Neurodegenerative Disease	p. 503
Epilepsy and Adult Neurogenesis	p. 535
Neurogenesis following Stroke Affecting the Adult Brain	p. 549
Comparative Neurogenesis
Adult Neurogenesis in Teleost Fish	p. 571
Neurogenesis in the Adult Songbird: A Model for Inducible Striatal Neuronal Addition	p. 593
Adult Human Neurogenesis: A Response to Cell Loss and New Circuitry Requirements?	p. 619
Adult Hippocampal Neurogenesis in Natural Populations of Mammals	p. 645
Index	p. 661
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