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Advanced Chemical Biology Chemical Dissection and Reprogramming of Biological Systems

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2023-03-01
  • Publisher: Wiley-VCH

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Advanced Chemical Biology

The modern approach to teaching chemical biology

Advanced Chemical Biology is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections.

Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course.

Written by authors and editors coming from the leading scientific institutions that have developed the concepts and technologies for this discipline, Advanced Chemical Biology includes specific information on topics like:

  • DNA function, synthesis and engineering, chemical approaches to genome integrity, and RNA function, synthesis, and probing
  • Chemical approaches to transcription and RNA regulation in vivo, chemical biology of genome engineering, and peptide/protein synthesis and engineering
  • Directed evolution for chemical biology, chemical biology of cellular metabolism, chemical biology of lipids, and protein post-translational modifications
  • Chemical glycobiology, chemical and enzymatic modification of proteins, genetic code expansion, bio-orthogonal chemistry, and cellular imaging

With its broad scope and focus on turning concepts into applications, Advanced Chemical Biology is an excellent starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer.

With a Foreword by Nobel Laureate Carolyn Bertozzi.

Author Biography

Howard C. Hang, Ph.D.
B.Sc. in Chemistry 1998, University of California, Santa Cruz (Joseph Konopelski)
Ph.D. in Chemistry 2003, University of California, Berkeley (Carolyn Bertozzi)
Damon Runyon Postdoctoral Fellow 2004 - 2006, Whitehead Institute (Hidde Ploegh)
Assistant Professor and Head of Lab, 2007 - 2012, The Rockefeller University
Associate Professor and Head of Lab, 2013 - present, The Rockefeller University
Awards: Irma T. Hirschl/Monique Weill-Caulier Trust Research Award, 2007; Ellison Medical Foundation New Scholar Award, 2008; The Rockefeller University Distinguished Teaching Award, 2011; Eli Lilly Award in Biological Chemistry, 2017

Matthew R. Pratt, Ph.D.
B.S. in Biochemistry and Math 1999, University of Arizona, Tucson (Robin Polt)
Ph.D. in Chemistry 2004, University of California, Berkeley (Carolyn Bertozzi)
American Cancer Society Fellow 2005-2009, Rockefeller University (Tom Muir)
Associate Professor, University of Southern California, Los Angeles
Awards: Damon Runyon Rachleff-Innovator (2011), USC General Education Teaching Award (2013), Susan G. Komen Career Catalyst Award (2014), American Cancer Society Research Scholar (2015), American Chemical Society - David Y. Gin Young Investigator Award (2015), American Cancer Society Hope Award (2016).

Jennifer A. Prescher, Ph.D.
B.S. in Chemistry and Mathematics 2001, University of Wisconsin-La Crosse (Aaron Monte)
Ph.D. in Chemistry 2006, University of California, Berkeley (Carolyn Bertozzi)
Susan G. Komen and Molecular Imaging Fellow, Stanford University, 2007 - 2010 (Chris Contag)
Assistant Professor, 2010 - 2016, University of California, Irvine
Associate Professor, 2016 - 2018, University of California, Irvine
Full Professor, 2018 - Present, University of California, Irvine
Awards: Scialog Fellow (2018), UCI Distinguished Assistant Professor Award for Research (2016), ACS Women in Chemistry Rising Star (2016), Thieme Chemistry Journal Award (2016), Novartis Early Career Award in Organic Chemistry (2015), Camille and Henry Dreyfus Teacher-Scholar (2015), Alfred P. Sloan Research Fellowship (2015), NSF CAREER Award (2014), Cottrell Scholar (2014), Kavli Fellow (2014), UCI Outstanding Contributions to Undergraduate Education Award (2013)

Table of Contents

DNA function, synthesis and engineering
Chemical approaches to genome integrity and engineering
RNA function, synthesis and engineering
Chemical approaches to transcription and RNA regulation in vivo
Peptide synthesis and engineering
Protein engineering and semisynthesis
Biomolecular structure determination
Biomolecular structure prediction and design
Directed Evolution
Cellular metabolism
Membrane biology and lipid signaling
Posttranslational modifications
Chemical glycobiology
Genetic code expansion
Bioorthogonal chemistry
Cellular imaging
In vivo imaging
Natural product biosynthesis
Natural product discovery
Activity-based protein profiling
Chemical genetics
Development of small molecule probes and therapeutics
Metals in biology
Chemical redox-biology
Chemical microbiology
Chemical mammalian cell biology
Chemical developmental biology
Chemical immunology
Chemical neurobiology
Chemical plant biology
Chemical virology
Chemical parasitology

Supplemental Materials

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

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