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John McHutchison is a professor of medicine at Duke University Medical Center, and since 2002, Director of the DCRI’s Gastroenterology and Hepatology Research division.
Preface, xi
Section I Foundations for Understanding Antiviral Therapies in HCV
1 HCV Replication, 3Michael R. Beard
2 Hepatitis C Virus Genotypes, 12Scott A. Read and Mark W. Douglas
3 Immune Responses to HCV: Implications for Therapy, 17David G. Bowen
4 Mechanisms of Action of Antiviral Drugs: The Interferons, 25Edmund Tse and Michael R. Beard
5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs, 36Fred Poordad and Grace M. Chee
6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors, 43Lotte Coelmont, Leen Delang, Mathy Froeyen, Piet Herdewijn and Johan Neyts
7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors, 53Laurent Chatel-Chaix, Martin Baril and Daniel Lamarre
8 Measuring Antiviral Responses, 60Jean-Michel Pawlotsky and Stephane Chevaliez
Section II Efficacy and Clinical Use of Antiviral Therapies
9 Genotype 1: Standard Treatment, 67Rebekah G. Gross and Ira M. Jacobson
10 Individually Tailored Treatment Strategies in Treatment-na¨ive Chronic Hepatitis C Genotype 1 Patients, 74Johannes Wiegand and Thomas Berg
11 Genotype 1 Relapsers and Non-responders, 84Salvatore Petta and Antonio Crax`i
12 Standard Therapy for Genotypes 2/3, 90Kenneth Yan and Amany Zekry
13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3, 97Alessandra Mangia, Leonardo Mottola and Angelo Andriulli
14 Genotypes 2 and 3 Relapse and Non-response, 104Stella Mart´inez, Jose Maria Sanchez-Tapias and Xavier Forns
15 Hepatitis C Genotype 4 Therapy: Progress and Challenges, 113Sanaa M. Kamal
16 Antivirals in Acute Hepatitis C, 127Heiner Wedemeyer
17 Antivirals in Cirrhosis and Portal Hypertension, 132Diarmuid S. Manning and Nezam H. Afdhal
18 Treatment of Recurrent Hepatitis C Following Liver Transplantation, 140Ed Gane
19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations, 150Benjamin Terrier and Patrice Cacoub
20 Cytopenias: How they Limit Therapy and Potential Correction, 160Mitchell L. Shiffman
21 The Problem of Insulin Resistance and its Effect on Therapy, 169Venessa Pattullo and Jacob George
22 HIV and Hepatitis C Co-infection, 177Gail V. Matthews and Gregory J. Dore
23 HCV and Racial Differences, 185Andrew J. Muir
24 HCV and the Pediatric Population, 190Kathleen B. Schwarz
25 New Horizons: IL28, Direct-acting Antiviral Therapy for HCV, 196Alexander J. Thompson, John G. McHutchison and Geoffrey W. McCaughan
Index, 215
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