Advances in Alzheimer's and... | Buy

Proceedings of the 7th International Conference on Alzheimera??s Disease and Parkinsona??s Disease (ADPD), held March 9-13, 2005 in Sorrento, Italy. The subject matter of the ADPD conferences is unique in that it deals not only with issues related individually to Alzheimera??s disease and Parkinsona??s disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume, covering topics such as immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the history, epidemiology, clinical phenomenology, diagnosis, imaging, treatment ,and future perspectives of Alzheimera??s and Parkinsona??s Diseases.

Clinical Features and Treatment of Dementia Associated With Parkinson's Disease	p. 1
Neurogenetics in Parkinson's Disease	p. 9
Impaired DNA Repair Systems: Generation of Mitochondrial Dysfunction and Increased Sensitivity to Excitotoxicity	p. 17
Current Problems and Strategies in Motor Rehabilitation for Parkinson's Disease	p. 23
Critical Acute Akinesia in Parkinson's Disease Patients Concomitant with Additional Precipitating Factors Other Than Treatment Withdrawal: A Possible Lethal Complication	p. 31
Biomarkers for Early Detection of Parkinson's Disease: An Essential Challenge	p. 35
Neurotransmitter and Neurotrophic Factor-Secreting Cell Line Grafting for the Treatment of Parkinson's Disease	p. 51
Novel Therapeutic Target in PD: Experimental Models	p. 57
LRRK2 (Leucine-Rich Repeat Kinase 2) Gene on PARK8 Locus in Families with Parkinsonism	p. 75
Microglia Activation and Gene Expression of Cytokines in Parkinson's Disease	p. 91
Dissecting the Biochemical Pathways Mediated by Genes Implicated in Parkinson's Disease: Induction of DJ-1 Expression in A30P [alpha]-Synuclein Mice	p. 97
Neuroinflammation in Early Stages of Alzheimer's Disease and Parkinson's Disease	p. 113
Alzheimer's Disease, Parkinson's Disease, and Frontotemporal Dementias: Different Manifestations of Protein Misfolding	p. 123
Role of Oxidative Insult and Neuronal Survival in Alzheimer's and Parkinson's Diseases	p. 133
Redox Proteomics Identification of Oxidatively Modified Proteins in Alzheimer's Disease Brain and in Brain from a Rodent Model of Familial Parkinson's Disease: Insights into Potential Mechanisms of Neurodegeneration	p. 149
Biomarkers for Alzheimer's Disease and Parkinson's Disease	p. 169
Bioluminescent Imaging of Exeitotoxic and Endotoxic Brain Injury in Living Mice	p. 175
Alzheimer's Disease Neuroimaging Initiative	p. 183
Two Hits and You're Out? A Novel Mechanistic Hypothesis of Alzheimer Disease	p. 191
Vascular Risk Factors and Risk for Alzheimer's Disease and Mild Cognitive Impairment: Population Based Studies	p. 205
Cholesterol Transport and Production in Alzheimer's Disease	p. 211
Cholesterol and A[beta] Production: Methods for Analysis of Altered Cholesterol De Novo Synthesis	p. 221
Glycosaminoglycans and Analogs in Neurodegenerative Disorders	p. 231
Prospective Role of Glycosaminoglycans in Apoptosis Associated with Neurodegenerative Disorders	p. 247
Stem Cell Therapy in Alzheimer's Disease	p. 255
Oral A[beta] Vaccine Using a Recombinant Adeno-Associated Virus Vector in an Alzheimer's Disease Mouse Model	p. 265
In Vivo Targeting of Amyloid Plaques Via Intranasal Administration of Phage Anti-[beta]-Amyloid Antibodies	p. 273
Decreased ProBDNF: The Cause of Alzheimer's-Associated Neurodegeneration and Cognitive Decline?	p. 279
Shift in the Balance of TRKA and ProNGF in Prodromal Alzheimer's Disease	p. 285
Neuroprotective Effects of Trophic Factors and Natural Products: Involvement of Multiple Extracellular Kinases	p. 291
Intraneuronal A[beta] and Alzheimer's Disease	p. 297
Physiological Processing of the Cellular Prion Protein and [beta]APP: Enzymes and Regulation	p. 305
Expression of Wnt Receptors, Frizzled, in Rat Neuronal Cells	p. 317
Cell Models of Tauopathy	p. 325
Co-expression of FTDP-17 Human Tau and GSK-3[beta] (or APP[superscript SW]) in Transgenic Mice: Induction of Tau Polymerization and Neurodegeneration	p. 337
Enhanced Activation of NF-[kappa]B Signaling by Apolipoprotein E4	p. 343
Pleiotropic Effects of Apolipoprotein E in Dementia: Influence on Functional Genomics and Pharmacogenetics	p. 355
Up-regulation of the [alpha]-Secretase Pathway	p. 369
Frequency and Relation of Argyrophilic Grain Disease and Thorn-Shaped Astrocytes in Alzheimer's Disease	p. 375
Cellular Membranes as Targets in Amyloid Oligomer Disease Pathogenesis	p. 381
Ganglioside-Dependent Generation of a Seed for Alzheimer's Disease Amyloid	p. 387
Evidence That Amyloid Pathology Progresses in a Neurotransmitter-Specific Manner	p. 393
Rationale for Glutamatergic and Cholinergic Approaches for the Treatment of Alzheimer's Disease	p. 403
Cortical Cholinergic Lesion Causes A[beta] Deposition: Cholinergic-Amyloid Fusion Hypothesis	p. 411
Expression of Acetylcholinesterase in Alzheimer's Disease Brain: Role in Neuritic Dystrophy and Synaptic Scaling	p. 429
Role of [beta]-Amyloid in the Pathophysiology of Alzheimer's Disease and Cholinesterase Inhibition: Facing the Biological Complexity to Treat the Disease	p. 439
Dissociation Between the Potent [beta]-Amyloid Protein Pathway Inhibition and Cholinergic Actions of the Alzheimer Drug Candidates Phenserine and Cymserine	p. 445
Allosteric Potentiators of Neuronal Nicotinic Cholinergic Receptors: Potential Treatments for Neurodegenerative Disorders	p. 463
Index	p. 473
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