Advances in Chromatography: Volume 42

by Brown; Phyllis R.

• ISBN13: 9780824709501
• ISBN10: 0824709500
• Edition: 1st
• Format: Hardcover
• Copyright: 2003-01-14
• Publisher: CRC Press

Summary

This book investigates current trends in chemometrics, proteomics, column technology, and element-selective detection for pharmaceutical, medical, industrial, and environmental applications. It offers recent strategies to evaluate and assess materials in air, water, soil, and landfill samples, to determine the amount of hydrocarbons in the atmosphere and calculate their atmospheric lifetimes, to utilize microfluidic devices for small-volume biological analyses, and to examine the role of proteins in cellular signaling, structures, and pathways. With contributions from leading authorities, this text is an enriching guide for analytical, organic, inorganic, clinical, and physical chemists, chromatographers, biochemists, biotechnologists, and upper-level undergraduate and graduate students in these disciplines.

Table of Contents

Contributors to Volume 42	iii
Contents of Other Volumes	xi
Chemometric Analysis of Comprehensive Two-Dimensional Separations	1	(42)
Robert E. Synovec
Bryan J. Prazen
Kevin J. Johnson
Carlos G. Fraga
Carsten A. Bruckner
Introduction
Comprehensive 2-D Separations
Chemometric Analysis of Chemical Separation Data
Comprehensive 2-D Separations/Gram Analysis
Feature Selection and Pattern Recognition
Scope and Future Directions
References
Column Technology for Capillary Electrochromatography	43	(64)
Luis A. Colon
Todd D. Maloney
Jason Anspach
Hector Colon
Introduction
Open Tubular Columns
Packed Columns
Monolithic Columns
Microfabricated Devices
Final Remark
References
Gas Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection (GP-ICP MS)	107	(32)
Brice Bouyssiere
Joanna Szpunar
Gaetne Lespes
Ryszard Lobinski
Introduction
Feasibility of an Analysis by GC-ICP MS
Sample Preparation for GC-ICP MS
Interface Between GC and ICP MS
Low-Power ICP as a Tunable Ionization Source for GC Effluents
Mass Spectrometric Detection in Gas Chromatography
GC-ICP MS Studies Using Stable Isotopes
Selected Applications
References
GC-MS Analysis of Halocarbons in the Environment	139	(102)
Filippo Mangani
Michela Maione
Pierangela Palma
Introduction
The Analytical Problem
References
Microfluidics for Ultrasmall-Volume Biological Analysis	241	(28)
Todd O. Windman
Barb J. Wyatt
Mark A. Hayes
Introduction
Microscopy
Direct Probes
Microsampling
Direct Sampling
Capillary Electrophoresis and Electrokinetic Effects
Direct Sampling Combined with Microfluidic Devices
Microfluidics on Microchip Devices
Polymers
Channel Geometry
Fabrication Techniques
Detection
Biology
Biological Application and Detection
References
Recent Trends in Proteome Analysis	269	(54)
Pier Giorgio Righetti
Annalisa Castagna
Mahmoud Hamdan
Introduction
A Glimpse at Modern Technologies
Some Basic Methodologies Pertaining to 2-D Page
Solubilization Cocktail
Sample Reduction and Alkylation: When, Why, and How?
Mass Spectrometry and the Proteome: An Indissoluble Connubium
Informatics and Proteome: Interrogating Databases
Quantitative Proteomics
Pre-Fractionation in Proteome Analysis
Conclusions: Quo Vadis, Proteome?
References
Improving Our Understanding of Reversed-Phase Separations for the 21st Century	323	(54)
Patrick D. McDonald
Introduction
Background
Curious Incidents
Interdisciplinary Ideas and Inferences
Conclusions
References
Clinical Applications of High-Performance Affinity Chromatography	377	(44)
David S. Hage
Introduction
Traditional Methods
Chiral Separations
Chromatographic Immunoassays
Combined Analytical Systems
References
Index	421