Advances in Clinical Chemistry

by Makowski

• ISBN13: 9780123737045
• ISBN10: 0123737044
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-07-10
• Publisher: Elsevier Science

Summary

Volume forty-four of the Advances in Clinical Chemistrylt;/b> series contains review articles of wide interest to clinical laboratory scientists and diagnostic adventurers. Articles in this volume cover such topics as Caspases in Myocardial Infarction; Deamidated Gliadin Peptides as Targets for Celiac Disease Specific Antibodies; Urokinase Receptor Variants in Tissue and Body Fluids; Proteomics in Cancer; Paraneoplastic Neurological Syndromes and Oncnerual Antibodies: Clinical and Immunological Aspects; Pathophysiologic Mechanisms of Angiogenesis; Bikunin (Urinary Trypsin Inhibitor): Structure, Biological Relevance and Measurement; and Gene Expression Assays.

Table of Contents

Contributors	p. ix
Preface	p. xi
Caspases in Myocardial Infarction
Abstract	p. 1
Introduction	p. 2
Apoptosis and the Heart	p. 3
Caspases	p. 3
Activation of Caspases	p. 4
Activation of Caspases in the Heart	p. 5
Functional Significance of Caspases	p. 6
Caspases for Detection of Apoptosis	p. 9
Apoptosis and Caspases in MI	p. 11
Apoptosis of Cardiomyocytes in Ventricular Remodeling After MI	p. 14
Apoptosis of Other Cell Types in the Evolution of Fibrous Scar	p. 15
Anti-Caspase Treatment	p. 18
Conclusion	p. 23
References	p. 23
Deamidated Gliadin Peptides as Targets for Celiac Disease-Specific Antibodies
Abstract	p. 36
Introduction	p. 36
Prolamins as Cereal Storage Proteins	p. 37
Pathogenesis of CD	p. 38
Serological Diagnosis of CD	p. 42
Gliadin Antibodies of CD Patients Recognize Deamidated Gliadin	p. 45
Enhanced Diagnostic Potential of Glutamine-Glutamic Acid Substituted Gliadin-Analogous Peptides	p. 47
Does Epitope Specificity of Gliadin Antibodies of CD Patients Mirror Substrate Specificity of tTG?	p. 49
Relation Between B- and T-Cell Epitopes of Gliadin	p. 51
Conclusions	p. 52
References	p. 53
Urokinase Receptor Variants in Tissue and Body Fluids
Abstract	p. 66
Introduction	p. 67
Monoclonal Antibodies to uPAR	p. 77
Immunoassays for the Quantification of uPAR	p. 79
uPAR in Cancer	p. 82
Other Diseases	p. 91
Conclusions and Perspectives	p. 91
References	p. 93
Proteomics in Cancer
Abstract	p. 104
Introduction	p. 104
Sampling for Proteomic Analysis	p. 106
Proteomic Technologies Used in Cancer Proteomics	p. 110
Proteomic Applications in Cancer	p. 114
What Has Been Achieved in Cancer Proteomics?	p. 127
Conclusion	p. 133
References	p. 134
Paraneoplastic Neurological Syndromes and Onconeural Antibodies: Clinical and Immunological Aspects
Abstract	p. 144
Introduction	p. 144
Onconeural Antigens	p. 148
Paraneoplastic Syndromes of the CNS	p. 149
PNS of the Peripheral Nervous System	p. 155
Paraneoplastic Nervous System Syndromes of the Neuromuscular Junction	p. 159
Diagnosis of Paraneoplastic Nervous System Syndromes	p. 159
Pathogenesis of Paraneoplastic Nervous System Syndromes	p. 165
Therapy for Paraneoplastic Nervous System Syndromes	p. 170
Future Aspects	p. 172
References	p. 172
Pathophysiological Mechanisms of Angiogenesis
Abstract	p. 188
Introduction	p. 189
Measuring the Angiogenic Process	p. 191
Endothelial Cells and the Initiation of Angiogenesis	p. 193
Differential Angiogenic Pathways	p. 198
Impact of the Vessel's Environment on Angiogenesis	p. 204
Angiogenesis Biomarkers for Assessing Human Disease	p. 205
Therapeutic Targeting of Angiogenesis	p. 210
Conclusion	p. 211
References	p. 212
Bikunin (Urinary Trypsin Inhibitor): Structure, Biological Relevance, and Measurement
Abstract	p. 224
Introduction	p. 225
Roles in Biological Processes	p. 230
Diagnostic Testing	p. 233
Pathophysiology of Bik	p. 235
Summary	p. 240
References	p. 240
Gene Expression Assays
Abstract	p. 248
Introduction	p. 248
The Technology	p. 250
Gene Expression Assays in Cancer	p. 256
Applications of Arrays to Neurological Disorders	p. 265
Application of Microarrays to Neuropsychiatric Disorders	p. 277
Future Advances	p. 281
References	p. 282
Index	p. 293
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