Advances in Clinical Chemistry

by Makowski

• ISBN13: 9780123747983
• ISBN10: 0123747988
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-11-16
• Publisher: Elsevier Science

Summary

Volume 49 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting-edge microarray technology.* Leading experts from academia and clinical laboratory science * Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Table of Contents

Contributors	p. ix
Preface	p. xi
High-Sensitivity Troponin: A New Tool for Pathophysiological Investigation and Clinical Practice
Abstract	p. 2
Background and Aim	p. 2
Introduction: Troponin Framework Within Myocardial Cells and Release Kinetics After Myocardial Damage	p. 4
Impact of the New Definition of Myocardial Infarction on Laboratory Practice and Instrumentation: The Need for High-Sensitivity cTnI and cTnT Methods	p. 5
The Impact of High-Sensitivity cTnI and cTnT Methods on Clinical Practice	p. 9
High-Sensitivity cTnI and cTnT Methods: A Powerful Tool for Monitoring Physiological Renewal and Pathological Remodeling of the Myocardial Tissue?	p. 19
Use of High-Sensitivity cTnI and cTnT Methods in Multimarker Approach for Early Screening: An Increase in Diagnostic and Prognostic Efficiency?	p. 22
Conclusion	p. 23
References	p. 24
Biochemical Biomarkers of Oxidative Collagen Damage
Abstract	p. 31
The Collagen Family: Structure and Biochemistry	p. 32
Chemical Nature and Reactivity of Oxygen	p. 33
In Vivo Production of RNOS	p. 35
RNOS Biological Activity	p. 37
In Vivo Markers of Oxidant Stress	p. 39
Oxidant-Induced Changes in Collagens	p. 40
Biomarkers of Collagen Oxidative Damage	p. 43
Critical Comments and Concluding Remarkers	p. 48
References	p. 49
Biochemical Basis of Fabry Disease with Emphasis on Mitochondrial Function and Protein Trafficking
Abstract	p. 57
Introduction	p. 58
Inheritance	p. 58
Clinical Picture	p. 59
Diagnosis	p. 59
Treatment	p. 60
Biochemical Basis	p. 62
References	p. 68
Urinary Biomarkers for the Detection of Renal Injury
Abstract	p. 73
Introduction	p. 74
Biomarker Development for Kidney Diseases	p. 75
Biomarkers for AKI	p. 81
Biomarker Development and Implementation	p. 90
Summary	p. 91
References	p. 92
Biomarkers of Bone and Mineral Metabolism Following Bone Marrow Transplantation
Abstract	p. 99
Introduction	p. 100
Clinical Features of BMT-Related Bone Loss	p. 100
Changes in Bone-Turnover Markers After BMT	p. 102
Calcium, Parathyroid Hormone (PTH), and Vitamin D	p. 109
Sex Hormones	p. 110
RANKL and Osteoprotegerin	p. 112
Cytokines and Growth Factors	p. 114
Conclusion	p. 115
References	p. 116
Factor V Leiden and Activated Protein C Resistance
Abstract	p. 121
Introduction	p. 122
The Protein C System	p. 123
APC Resistance and FV Leiden	p. 130
Conclusions and Perspectives	p. 143
References	p. 144
Self-Assembled Tethered Bimolecular Lipid Membranes
Abstract	p. 159
Introduction	p. 160
Assembly of tBLMs from Telechelics and Reconstitution of Proteins	p. 162
The Peptide-Tethered Lipid Bilayer Membrane (peptBLM)	p. 165
Protein-Tethered Bilayer Lipid Membrane (protBLM)	p. 170
Conclusions	p. 174
References	p. 177
Index	p. 181
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