Advances in Clinical Chemistry

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2009-11-01

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Volume 49 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting-edge microarray technology.* Leading experts from academia and clinical laboratory science * Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies

Table of Contents

Contributorsp. ix
Prefacep. xi
High-Sensitivity Troponin: A New Tool for Pathophysiological Investigation and Clinical Practice
Abstractp. 2
Background and Aimp. 2
Introduction: Troponin Framework Within Myocardial Cells and Release Kinetics After Myocardial Damagep. 4
Impact of the New Definition of Myocardial Infarction on Laboratory Practice and Instrumentation: The Need for High-Sensitivity cTnI and cTnT Methodsp. 5
The Impact of High-Sensitivity cTnI and cTnT Methods on Clinical Practicep. 9
High-Sensitivity cTnI and cTnT Methods: A Powerful Tool for Monitoring Physiological Renewal and Pathological Remodeling of the Myocardial Tissue?p. 19
Use of High-Sensitivity cTnI and cTnT Methods in Multimarker Approach for Early Screening: An Increase in Diagnostic and Prognostic Efficiency?p. 22
Conclusionp. 23
Referencesp. 24
Biochemical Biomarkers of Oxidative Collagen Damage
Abstractp. 31
The Collagen Family: Structure and Biochemistryp. 32
Chemical Nature and Reactivity of Oxygenp. 33
In Vivo Production of RNOSp. 35
RNOS Biological Activityp. 37
In Vivo Markers of Oxidant Stressp. 39
Oxidant-Induced Changes in Collagensp. 40
Biomarkers of Collagen Oxidative Damagep. 43
Critical Comments and Concluding Remarkersp. 48
Referencesp. 49
Biochemical Basis of Fabry Disease with Emphasis on Mitochondrial Function and Protein Trafficking
Abstractp. 57
Introductionp. 58
Inheritancep. 58
Clinical Picturep. 59
Diagnosisp. 59
Treatmentp. 60
Biochemical Basisp. 62
Referencesp. 68
Urinary Biomarkers for the Detection of Renal Injury
Abstractp. 73
Introductionp. 74
Biomarker Development for Kidney Diseasesp. 75
Biomarkers for AKIp. 81
Biomarker Development and Implementationp. 90
Summaryp. 91
Referencesp. 92
Biomarkers of Bone and Mineral Metabolism Following Bone Marrow Transplantation
Abstractp. 99
Introductionp. 100
Clinical Features of BMT-Related Bone Lossp. 100
Changes in Bone-Turnover Markers After BMTp. 102
Calcium, Parathyroid Hormone (PTH), and Vitamin Dp. 109
Sex Hormonesp. 110
RANKL and Osteoprotegerinp. 112
Cytokines and Growth Factorsp. 114
Conclusionp. 115
Referencesp. 116
Factor V Leiden and Activated Protein C Resistance
Abstractp. 121
Introductionp. 122
The Protein C Systemp. 123
APC Resistance and FV Leidenp. 130
Conclusions and Perspectivesp. 143
Referencesp. 144
Self-Assembled Tethered Bimolecular Lipid Membranes
Abstractp. 159
Introductionp. 160
Assembly of tBLMs from Telechelics and Reconstitution of Proteinsp. 162
The Peptide-Tethered Lipid Bilayer Membrane (peptBLM)p. 165
Protein-Tethered Bilayer Lipid Membrane (protBLM)p. 170
Conclusionsp. 174
Referencesp. 177
Indexp. 181
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