Advances in Enzyme Regulation

by Weber

• ISBN13: 9780080447384
• ISBN10: 0080447384
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-04-03
• Publisher: Elsevier Science

Summary

Volume 45 of Advances in Enzyme Regulationlt;/b> is the proceedings of the 45th International Synthesis in Normal and Neoplastic Tissues held at Indiana University School of Medicine Indianapolis, Indiana September 27-28, 2004. Volume 45 concentrates on subjects which have reached the stage of productive summarizaiton and critical evaluation in the light of extensive new results. This book also lives up to its goal of advancing a few steps ahead of the general front of mammalian enzymic and metabolic regulation studies. *Latest information about mammalian enzymic and metabolic regulation studies *Comprehensive lab resource and teaching companion *International contributors from academia and industry

Table of Contents

Acknowledgments	p. xv
List of participants	p. xvii
Nuclear Control
Implications for Nuclear Organization and Gene Transcription of Lamin A/C Specific Mutations	p. 1
Spatio-Temporal Dynamics of Genomic Organization and Function in the Mammalian Cell Nucleus	p. 17
Metabolic Design and Regulation
Metabolic Design Principles: Chemical and Physical Determinants of Cell Chemistry	p. 27
Down-regulation of Increased Signal Transduction Capacity in Human Cancer Cells	p. 37
Ras and Regulation
Ras Initiates Phosphatidyl-Inositol-3-Kinase(PI3K)/PKB Mediated Signalling Pathways in Untransformed Human Peripheral Blood T Lymphocytes	p. 52
Functional Analysis and Secondary Expression Profiling of Candidate Genes Deregulated in Conjunction with Oncogenic Ras Signaling	p. 63
Controls and Apoptosis
Induction of Apoptosis in p53-Deficient L1210 Cells by an I KAPPA B-Alpha Inhibitor (Bay 11-7085) via a NF KAPPA-B-Independent Mechanism	p. 85
Regulation of Gene and Protein Expression in Cardiac Myocyte Hypertrophy and Apoptosis	p. 94
Regulation of Key Enzymes
Peptide Inhibitors of Mammalian Ribonucleotide Reductase	p. 112
Nuclear Function and Human Neoplasia
Nuclear Phospholipase C [beta]1, Regulation of the Cell Cycle and Progression of Acute Myeloid Leukemia	p. 126
Combinatorial Organization of the Transcriptional Regulatory Machinery in Biological Control and Cancer	p. 136
Evolutionary Conserved Signal Pathways
Phosphatidylinositol Transfer Protein Function in the Yeast Saccharomyces cerevisiae	p. 155
Modification of Protein Sub-Nuclear Localization by Synthetic Phosphoinositides: Evidence for Nuclear Phosphoinositide Signaling Mechanisms	p. 171
Signal Transduction and Structural Impact
Role of Signal Transduction and Actin in G1 Phase Progression	p. 186
Emerging Roles of Phosphatidylinositol Monophosphates in Cellular Signaling and Trafficking	p. 201
Signal Transduction
Human Guanylate Binding Protein-1 (hGBP-1) Characterizes and Establishes a Non-Angiogenic Endothelial Cell Activation Phenotype in Inflammatory Diseases	p. 215
Special Symposium Lecture: H.L. Pearce
The Evolution of Cancer Research and Drug Discovery at Lilly Research Laboratories	p. 228
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