Advances in Enzymology and Related Areas of Molecular Biology

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  • Format: Hardcover
  • Copyright: 2011-05-24
  • Publisher: Wiley

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This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes.

Author Biography

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic Inorganic Review panel (Canada). Professor Toone is also the Deputy Director for Technology for the Advanced Research Projects Agency-Energy (ARPA-E) of the Department of Energy and directs the ARPA-E's Electrofuels program.

Table of Contents

Contributorsp. vii
Prefacep. xi
Structure and Mechanism of RND-Type Multidrug Efflux Pumpsp. 1
Efflux Pumps of Gram-Negative Bacteria: Genetic Responses to Stress and the Modulation of Their Activity by pH, Inhibitors, and Phenothiazinesp. 61
Efflux Pumps of the Resistance-Nodulation-Division Family: A Perspective of Their Structure, Function, and Regulation in Gram-Negative Bacteria
The MFS Efflux Proteins of Gram-Positive and Gram-Negative Bacteriap. 147
Efflux Pumps as an Important Mechanism for Quinolone Resistancep. 167
Xenobiotic Efflux in Bacteria and Fungi: A Genomics Updatep. 237
A Survey of Oxidative Paracatalytic Reactions Catalyzed by Enzymes That Generate Carbanionic Intermediates: Implications for ROS Production, Cancer Etiology, and Neurodegenerative Diseasesp. 307
Author Indexp. 361
Subject Indexp. 403
Table of Contents provided by Ingram. All Rights Reserved.

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