Advances in Enzymology and Related Areas of Molecular Biology, Volume 77

by Toone, Eric J.

• ISBN13: 9780470638354
• ISBN10: 0470638354
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-05-24
• Publisher: Wiley

Summary

This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes.

Author Biography

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic Inorganic Review panel (Canada). Professor Toone is also the Deputy Director for Technology for the Advanced Research Projects Agency-Energy (ARPA-E) of the Department of Energy and directs the ARPA-E's Electrofuels program.

Table of Contents

Contributors	p. vii
Preface	p. xi
Structure and Mechanism of RND-Type Multidrug Efflux Pumps	p. 1
Efflux Pumps of Gram-Negative Bacteria: Genetic Responses to Stress and the Modulation of Their Activity by pH, Inhibitors, and Phenothiazines	p. 61
Efflux Pumps of the Resistance-Nodulation-Division Family: A Perspective of Their Structure, Function, and Regulation in Gram-Negative Bacteria
The MFS Efflux Proteins of Gram-Positive and Gram-Negative Bacteria	p. 147
Efflux Pumps as an Important Mechanism for Quinolone Resistance	p. 167
Xenobiotic Efflux in Bacteria and Fungi: A Genomics Update	p. 237
A Survey of Oxidative Paracatalytic Reactions Catalyzed by Enzymes That Generate Carbanionic Intermediates: Implications for ROS Production, Cancer Etiology, and Neurodegenerative Diseases	p. 307
Author Index	p. 361
Subject Index	p. 403
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