Advances in Genetics

by Friedmann; Dunlap; Goodwin

• ISBN13: 9780123943958
• ISBN10: 0123943957
• Edition: 1st
• Format: Hardcover
• Copyright: 2012-10-02
• Publisher: Elsevier Science

Summary

The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes imporatnt reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. * Includes methods for testing with ethical, legal, and social implications * Critically analyzes future prospects

Table of Contents

Contributors	p. vii
From Pluripotency to Islets: miRNAs as Critical Regulators of Human Cellular Differentiation	p. 1
Introduction	p. 2
miRNAs and ESCs	p. 4
miRNAs and ESC Pluripotency	p. 4
miRNAs that Regulate Early Cell Fate Decisions in hESC	p. 10
miRNAs that Regulate Endoderm and Pancreatic Precursor Formation	p. 15
miRNAs that Regulate Pancreatic Endocrine Cell Function	p. 19
Conclusions and Future Directions	p. 24
Acknowledgments	p. 25
References	p. 25
The Genetics of Dystonias	p. 35
Introduction	p. 36
Clinical Features	p. 38
Primary Dystonia	p. 45
Dystonia Plus	p. 55
Heredodegenerative Dystonia	p. 60
Dystonia in Association with other Neurogenetic Disorders	p. 62
Conclusions	p. 73
Acknowledgments	p. 74
References	p. 74
Exome Sequencing and Advances in Crop Improvements	p. 87
Introduction	p. 88
Sequencing: Tools and Techniques	p. 89
Exome Sequencing for Crop Improvement	p. 100
Crop Improvement Beyond Exome Sequencing	p. 108
Conclusions	p. 113
Competing Interests	p. 114
Acknowledgments	p. 114
Abbreviations	p. 114
References	p. 114
Applications of Functional Protein Microarrays in Basic and Clinical Research	p. 123
Introduction	p. 124
Fabrication of Functional Protein Microarrays	p. 126
Signal Detection	p. 132
Applications of Functional Protein Microarrays	p. 136
Outlook	p. 149
Acknowledgements	p. 150
References	p. 150
Index	p. 157
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