Advances in Genetics

by Goodwin

• ISBN13: 9780123864819
• ISBN10: 012386481X
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-12-02
• Publisher: Elsevier Science

Summary

The field of Genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge gained from genetics research. Advances in Genetics continually publishes important, timely reviews from leaders in the field that cover a broad range of topics of interest to geneticists and their colleagues in affiliated disciplines. Important, timely reviews from leaders in the field. Cover a broad range of topics of interest to geneticists and their colleagues in affiliated disciplines.

Table of Contents

Contributors	p. vii
Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC)	p. 1
Introduction	p. 2
Chemosensation	p. 7
Mechanosensation	p. 10
Peripheral Pain	p. 15
Conclusions	p. 17
References	p. 17
Genetic and Phenotypic Consequences of Introgression Between Humans and Neanderthals	p. 27
Introduction	p. 28
The First Genetic Evidence for Introgression in Our Species	p. 29
Evidence for Introgression Obtained from Present-Day Human Genomes	p. 30
History of Hominans in Europe	p. 32
Comparison of Middle European Neanderthal Nuclear DNA with Modern Human Nuclear DNA	p. 37
The ABBA-BAB A Test for Introgression	p. 38
Different Regions of the Neanderthal Genome are Found in Different Modern Humans	p. 41
The Genetic Contribution of the Denisovans to Our Species	p. 44
Possible Range of Phenotypic Impacts of Neanderthal and Denisovan Introgressions into Modern Humans	p. 45
Acknowledgments	p. 50
References	p. 50
Genomic Approaches to Understanding Hox Gene Function	p. 55
Introduction: Historical Perspective	p. 56
The Molecular Genetics of Hox Complexes: Conservation and Colinearity	p. 59
Hox Target Genes and Functions	p. 62
Early Experiments to Identify Hox Target Genes	p. 65
Genomic Approaches to Identifying Hox Target Genes	p. 66
Microarray Expression Profiling	p. 68
ChIP Approaches	p. 73
Computational Approaches	p. 80
Prospects	p. 81
References	p. 84
GATA Transcription Factors in the Developing Reproductive System	p. 93
Introduction	p. 94
Molecular Control of Gonadal Development	p. 99
Canonical WNT Signaling Control of Gonadal Development	p. 102
The GATA-FOG Transcriptional Partnership	p. 103
GATA4-FOG2 Control of Gonadal Development	p. 105
Conclusions	p. 119
Acknowledgment	p. 120
References	p. 120
Index	p. 135
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