Advances in Immunology

by Alt

• ISBN13: 9780120224814
• ISBN10: 012022481X
• Edition: 1st
• Format: Hardcover
• Copyright: 2003-12-19
• Publisher: Elsevier Science

Summary

Volume 81 of Advances in Immunology contains articles on a vast range of immunology topics including the regulation of the immune response by the interaction of chemokines and proteases as well as roles of the Semaphorin Family in immune regulation. It has a chapter devoted to B Lymphoid Neoplasms of Mice and another on the Zebrafish as a model organism to study development of the immune system. This volume will be of interest to immunologists in all industries. * Edited by a new editor, Frederick W. Alt * Covers molecular mechanisms of host-pathogen interaction * Discusses prions and the immune system

Table of Contents

CONTRIBUTORS	ix
FOREWORD	xiii
Regulation of the Immune Response by the Interaction of Chemokines and Proteases
SOFIE STRUYF, PAUL PROOST, AND JO VAN DAMME
I. Introduction to Chemokines I
II. Posttranslational Modification of CXC Chemokines	13	(7)
III. CC Chemokines as Protease Substrates	20	(3)
IV. The CD26-Chemokine Connection	23	(9)
References	32	(13)
Molecular Mechanisms of Host-Pathogen Interaction: Entry and Survival of Mycobacteria in Macrophages
JOHN GATFIELD AND JEAN PIETERS
I. Introduction	45	(6)
II. Innate Recognition of Pathogens	51	(6)
III. Phagocytosis and Intracellular Trafficking in Macrophages	57	(8)
IV. Intracellular Survival of Bacterial Pathogens	65	(5)
V. Mycobacterial Infection	70	(14)
VI. Conclusions	84	(1)
References	85	(12)
B Lymphoid Neoplasms of Mice: Characteristics of Naturally Occurring and Engineered Diseases and Relationships to Human Disorders
HERBERT C. MORSE III, TOM MCCARTY, CHEN-FENGQI, TED A. TORREY, ZOHREH NAGHASHFAR, SISIR K. CHATTOPADHYAY, TORGNY N. FREDRICKSON, AND JANET W. HARTLEV
I. Introduction	97	(5)
II. Classification of Mouse B Cell-lineage Lymphomas	102	(7)
III. Pathogenesis of Spontaneous B Cell-lineage Neoplasms	109	(7)
IV. Conclusions	116	(1)
References	116	(7)
Prions and the Immune System: A Journey Through Gut, Spleen, and Nerves
ADRIANO AGUZZI
I. Prion Biology: Some Basic Facts	123	(5)
II. Peripheral Entry Sites of Prions: Complicity of Immune Cells	128	(6)
III. Lymphocytes and Prion Pathogenesis	134	(3)
IV. Prion Hideouts in Lymphoid Organs	137	(4)
V. A Spleen is not a Lymph Node: Idiosyncrasies in the Lymphotropism of Prions	141	(2)
VI. Sympathetic Nerves: A Neuroimmune Link?	143	(5)
VII. Innate Immunity and Antiprior Defense	148	(2)
VIII. Adaptive Immunity and Pre-Exposure Prophylaxis Against Prions	150	(3)
IX. The Prion Doppelganger	153	(5)
X. Prion Immunology: Quo Vadis?	158	(1)
XI. An Essential Glossary of Prion Jargon	159	(1)
References	160	(13)
Roles of the Semaphorin Family in Immune Regulation
ATSUSHI KUMANOGOH AND HITOSHI KIKUTANI
I. Overview	173	(4)
II. Class IV Semaphorin (1): CD100/Sema4D	177	(10)
III. Class IV Semaphorin (2): Sema4A	187	(4)
IV. Virus-Encoded Semaphorins and their Cellular Counterparts	191	(1)
V. Class III Semaphorin: Sema3A in Immune Cell Migration	192	(1)
VI. Neuropilen-1 in initial T cell/DC Contacts	193	(1)
VII. Perspectives	194	(1)
References	195	(4)
HLA-G Molecules: from Maternal-Fetal Tolerance to Tissue Acceptance
EDGARDO D. CAROSELLA, PHILIPPE MOREAU, JOËL LE MAOULT, MAGALI LE DISCORDE, JEAN DAUSSET, AND NATHALIE ROUAS-FREISS
I. Introduction	199	(2)
II. The HLA-G Gene and Polymorphism	201	(5)
III. Regulation of HLA-G Gene Expression	206	(7)
IV. Processing and Transport of HLA-G Molecules	213	(4)
V. Structural and Functional Properties of HLA-G Molecules	217	(8)
VI. Role of HLA-G in Normal and Pathological Pregnancies	225	(7)
VII. HLA-G in Organ Transplantation	232	(4)
VIII. HLA-G in Malignancies	236	(7)
References	243	(10)
The Zebrafisk as a Model Organism to Study Development of the Immune System
DAVID TRAVER, PHILIPPE HERBOMEL, E. ELIZABETH PATTON, RYAN D. MURPHEY, JEFFREY A. YODER, GARY W. LITMAN, ANDRÉ CATIC, CHRIS T. AMEMIYA, LEONARD I. ZON, AND NIKOLAUS S. TREDE
I. Introduction	253	(4)
II. Innate Immunity of Teleosts	257	(15)
III. Ontogeny of Adaptive Immunity from Fishes to Mammals	272	(18)
IV. Phenotypic Characterization of Zebrafisk Hematolymphoid Cells	290	(6)
V. The Zebrafisk as a Vertebrate Model System for Forward Genetic Screens	296	(10)
VI. Zebrafisk Screens for Lymphoid Mutants	306	(1)
VII. Reverse Genetic Approaches	307	(4)
VIII. Gene Expression Screens	311	(2)
IX. Use of Genomics: Getting Started with the Zebrafisk	313	(2)
X. Concluding Remarks: Impact of Zebrafisk on Immunology	315	(1)
References	316	(15)
Control of Autoimmunity by Naturally Arising Regulatory CD4+ T Cells
SHOHEI HORL, TAKESHI TAKAHASHI, AND SHIMON SAKAGUCHI
I. Introduction	331	(2)
II. Key Roles of Naturally Arising CD4 + Treg Cells in the Maintenance of Natural Self Tolerance: Induction of Autoimmune Disease in Normal Animals by their Depletion	333	(5)
III. The Phenotype of Naturally Arising CD4 + Treg Cells	338	(4)
IV. Functional Characteristics of CD25+CD4+ Treg Ex Vivo and In Vitro	342	(3)
V. Molecular Basis of Treg Functions	345	(7)
VI. The Development, Specificity, and Homeostasis of CD4+ Treg Cells	352	(12)
VII. Concluding Remarks	364	(1)
References	365	(8)
INDEX	373	(12)
CONTENTS OF RECENT VOLUMES	385