Advances in Immunology

by Alt

• ISBN13: 9780120224821
• ISBN10: 0120224828
• Edition: 1st
• Format: Hardcover
• Copyright: 2004-02-13
• Publisher: Elsevier Science

Summary

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Table of Contents

Contributors	ix
Transcriptional Regulation in Neutrophils: Teaching Old Cells New Tricks
Patrick P. McDonald
Introduction	1	(2)
The Stat Family of Transcription Factors	3	(14)
The NF-kB Family of Transcription Factors	17	(11)
Other Transcription Factors Potentially Involved in Neutrophil Activation	28	(5)
Conclusion	33	(16)
References	34	(15)
Tumor Vaccines
Freda K. Stevenson
Jason Rice
Delin Zhu
Introduction	49	(9)
Tumor Antigens	58	(3)
Vaccination Strategies	61	(23)
Concluding Summary	84	(21)
References	85	(20)
Immunotherapy of Allergic Disease
R. Valenta
T. Ball
M. Focke
B. Linhart
N. Mothes
V. Niederberger
S. Spitzauer
I. Swoboda
S. Vrtala
K. Westritschnig
D. Kraft
Introduction	105	(1)
Time Course and Pathophysiology of Type I Allergy	106	(9)
Possible Targets for Immunotherapy of Allergic Disease	115	(6)
Allergen-Specific Immunotherapy	121	(1)
Possible Mechanisms Underlying Allergen-Specific Immunotherapy	122	(5)
Modifications of Traditional, Allergen Extract-Based Immunotherapy	127	(5)
Possible Improvement of Immunotherapy by Using Recombinant Allergens	132	(3)
Genetic Engineering of Modified Allergens for Immunotherapy	135	(5)
Clinical Results with Modified Recombinant Allergens	140	(2)
Formulating Prophylactic Allergy Vaccines	142	(13)
References	143	(12)
Interactions of Immunoglobulins Outside the Antigen-Combining Site
Roald Nezlin
Victor Ghetie
Introduction	155	(1)
Fc Receptor-Binding Sites	155	(18)
Complement-Binding Sites	173	(5)
Proteins and Peptides Reacting with Fc	178	(3)
Proteins Reacting with Fab	181	(3)
Lectins	184	(2)
Proteins from Pathogens Reacting with Immunoglobulins	186	(11)
The Promiscuity of the Cy2--Cy3 Interface	197	(1)
Concluding Remarks	198	(19)
References	201	(16)
The Role of Antibodies in Mouse Models of Rheumatoid Arthritis, and Relevance to Human Disease
Paul A. Monach
Christophe Benoist
Diane Mathis
Rheumatoid Arthritis: Clinical and Pathological Features	217	(1)
RA: Theories of Pathogenesis	217	(3)
Effector Mechanisms of Antibody-Mediated Disease	220	(2)
Animal Models: General Considerations	222	(1)
Collagen-Induced Arthritis	223	(1)
Antigen-Induced Arthritis	224	(2)
Proteoglycan-Induced Arthritis	226	(1)
Streptococcal Cell Wall Arthritis	226	(1)
Pristane-Induced Arthritis	227	(1)
Zymosan-Induced Arthritis	227	(1)
Adjuvant Arthritis	228	(1)
K/BxN (Anti-GPI-Mediated) Arthritis	228	(2)
Arthritis in the Ipr Mouse	230	(1)
HTLV Transgenic Mouse	230	(1)
Human TNF Transgenic Mouse	231	(1)
IL-lra Knockout Mouse	232	(1)
Mutant IL-6 Receptor Mouse	232	(1)
Other Models	232	(1)
Summary of Mouse Models	233	(2)
Relevance to RA	235	(14)
References	238	(11)
MUC1 Immunobiology: From Discovery to Clinical Applications
Anda M. Vlad
Jessica C. Kettel
Nehad M. Alajez
Casey A. Carlos
Olivera J. Finn
Introduction	249	(1)
History of MUC1, the Pioneer Member of the Mucin Family	250	(1)
Structure, Biosynthesis, and Physiology of MUC1 in Health and Disease	251	(9)
MUC1 Immunobiology	260	(9)
MUC1 Vaccines	269	(7)
MUC1 Vaccines in Clinical Trials	276	(5)
Conclusions and Future Perspectives	281	(14)
References	284	(11)
Human Models of Inherited Immunoglobulin Class Switch Recombination and Somatic Hypermutation Defects (Hyper-IgM Syndromes)
Anne Durandy
Patrick Revy
Alain Fischer
Introduction	295	(3)
Hyper-IgM Syndrome Caused by a CD40-L/CD40 Activation Pathway Defect	298	(7)
Hyper-IgM Syndromes Associated with an Intrinsic Functional B Cell Deficiency	305	(10)
Other Hyper-IgM Syndromes	315	(1)
Concluding Remarks	316	(15)
References	317	(14)
The Biological Role of the C1 Inhibitor in Regulation of Vascular Permeability and Modulation of Inflammation
Alvin E. Davis, III
Shenghe Cai
Dongxu Liu
Introduction	331	(2)
C1 Inhibitor Structure and Function	333	(4)
Regulation of Complement Activation	337	(3)
Regulation of Contact System Activation	340	(5)
Regulation of Vascular Permeability	345	(4)
Modulation of Inflammation	349	(7)
Conclusions	356	(9)
References	357	(8)
Index	365	(12)
Contents of Recent Volumes	377