Advances in Immunology

by Alt

• ISBN13: 9780120224845
• ISBN10: 0120224844
• Edition: 1st
• Format: Hardcover
• Copyright: 2004-07-20
• Publisher: Elsevier Science

Summary

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. * Interactions between NK Cells and B Lymphocytes * Multitasking of helix-loop-helix proteins in lymphopoiesis * The pathogenesis of Diabetes in the NOD Mouse

Table of Contents

Contributors	ix
Interactions Between NK Cells and B Lymphocytes
Dorothy Yuan
Introduction	1	(1)
B Lymphocytes	1	(5)
NK Cells	6	(4)
NK--B-Cell Interactions In Vitro	10	(9)
In Vivo NK--B Cell Interactions	19	(7)
The Role of NK--B-Cell Interactions in Autoimmune Diseases	26	(2)
NK--B-Cell Interactions during Infections	28	(3)
Conclusions	31	(12)
References	31	(12)
Multitasking of Helix-Loop-Helix Proteins in Lymphopoiesis
Xiao-Hong Sun
Introduction	43	(11)
HLH Proteins and B-Cell Development	54	(4)
HLH Proteins and T-Cell Development	58	(5)
HLH Protein and Notch Signaling	63	(1)
HLH Proteins and Leukemia	64	(3)
Conclusions	67	(12)
References	67	(12)
Customized Antigens for Desensitizing Allergic Patients
Fatima Ferreira
Michael Wallner
Josef Thalhamer
Introduction	79	(1)
Allergy Diagnosis and Immunotherapy: From Extracts to Allergen Arrays and Engineered Vaccines	80	(3)
Novel Antigen Preparations to Improve SIT	83	(20)
Customized Allergen DNA Vaccines	103	(10)
Short Overview of Alternative Treatments and Supporting Adjuvants for SIT	113	(2)
Summary and Conclusions	115	(16)
References	116	(15)
Immune Response Against Dying Tumor Cells
Laurence Zitvogel
Noelia Casares
Marie O. Pequignot
Nathalie Chaput
Matthew L. Albert
Guido Kroemer
Introduction	131	(2)
Minimal Elements of the Antitumor Immune Response	133	(7)
Subroutines of Cell Death: Apoptosis and Necrosis	140	(10)
In Vivo Immunogenicity of Apoptotic Versus Necrotic Tumor Cells	150	(6)
Apoptosis: A Tolerogenic Type of Tumor Cell Death?	156	(3)
Strategies to Enhance the Immunogenicity of Dying Tumor Cells	159	(5)
Concluding Remarks	164	(17)
References	166	(15)
HMGB1 in the Immunology of Sepsis (Not Septic Shock) and Arthritis
Christopher J. Czura
Huan Yang
Carol Ann Amella
Kevin J. Tracey
Introduction	181	(2)
Modern Clinical Syndromes: Septic Shock is not Severe Sepsis	183	(1)
TNF is a Mediator of Septic Shock Syndrome, but Not Severe Sepsis Syndrome	184	(1)
HMGB1 and Anti-HMGB1 in Severe Sepsis, Not Septic Shock	185	(3)
Biochemistry and Molecular Biology of HMGB1	188	(3)
HMGB1 Signaling via RAGE and TLR2	191	(1)
Cytokine Activities of HMGB1	192	(2)
HMGB1 in Arthritis	194	(1)
Perspective and Future	195	(6)
References	196	(5)
Selection of the T-Cell Repertoire: Receptor-Controlled Checkpoints in T-Cell Development
Harald von Boehmer
Thymic Selection: A Historical Perspective	201	(6)
Early T-Cell Development	207	(9)
Late T-Cell Development	216	(6)
The Role of Thymic Selection in Recessive and Dominant Mechanisms of Self-Tolerance	222	(5)
Concluding Remarks	227	(12)
References	228	(11)
The Pathogenesis of Diabetes in the NOD Mouse
Michelle Solomon
Nora Sarvetnick
Introduction	239	(1)
Origin of the NOD Mouse	239	(1)
Pathogenesis of Diabetes in the NOD Mouse	240	(1)
Leukocytes Involved in the Pathogenesis of Diabetes in the NOD Mouse	241	(3)
Other Autoimmune Diseases Associated with the NOD Mouse	244	(1)
Breakthough Moments in the Study of the Pathogenesis of Diabetes in the NOD Mouse	245	(9)
Concluding Remarks	254	(11)
References	255	(10)
Index	265	(12)
Contents of Recent Volumes	277