Advances in Immunology

by Alt

• ISBN13: 9780120224869
• ISBN10: 0120224860
• Edition: 1st
• Format: Hardcover
• Copyright: 2005-02-23
• Publisher: Elsevier Science

Summary

Advances in Immunologylt;/b>, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research. * NOW AVAILABLE ONLINE! * Highly respected review series with an impact factor in 2003 of of 7.424 and ranked number 8/114 * New Editor, Frederick Alt

Table of Contents

Contributors	ix
Adenosine Deaminase Deficiency: Metabolic Basis of Immune Deficiency and Pulmonary Inflammation
Michael R. Blackburn and Rodney E. Kellems
Abstract	1	(1)
1. Introduction	2	(1)
2. ADA Deficiency in Humans	3	(4)
3. Models of ADA-Deficient Severe Combined Immunodeficiency Disease	7	(5)
4. Metabolic Disturbances in ADA Deficiency	12	(9)
5. Pulmonary Consequences of Elevated Adenosine	21	(10)
6. Additional Physiological Consequences of Elevated Adenosine	31	(2)
7. Concluding Remarks	33	(3)
References	36	(7)
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences
Darryll D. Dudley, Jayanta Chaudhuri, Craig H. Bassing, and Frederick W. Alt
Abstract	43	(1)
1. Overview: V(D)J and Class Switch Recombination	44	(3)
2. Antigen Receptor Gene Rearrangement	47	(14)
3. Regulation of V(D)J Recombination	61	(8)
4. Class Switch Recombination Employs Distinct Mechanisms for V(D)J Recombination	69	(24)
5. CSR-Related Diseases	93	(2)
6. Concluding Remarks	95	(2)
References	97	(16)
Isoforms of Terminal Deoxynucleotidyltransferase: Developmental Aspects and Function
To-Ha Thai and John F. Kearney
Abstract	113	(17)
1. V(D)J Recombination and Mediating Factors	114	(1)
2. Junctional Diversity	114	(1)
3. Origin of TdT	115	(2)
4. Transcriptional Regulation of the TdT Gene (Dntt)	117	(2)
5. TdT and Its Splice Variants	119	(4)
6. TdT Splice Variants and Junctional Diversity	123	(1)
7. The TdT Protein	124	(2)
8. TdT-Interacting Proteins	126	(1)
9. TdT Splice Variants and Repertoire Development	127	(3)
10. Biochemical Properties and Substrate Specificity of TdT	130	(1)
11. Expression of Human TdT in Human Leukemias	131	(1)
12. Possible Aberrant Activity of Human TdT in Leukemias	132	(1)
13. Conclusions	133	(1)
References	134	(3)
Innate Autoimmunity
Michael C. Carroll and V. Michael Holers
Abstract	137	(1)
1. Introduction	138	(1)
2. Ischemia-Reperfusion Injury	138	(1)
3. Reperfusion Injury Mediation by Natural Antibody	139	(1)
4. Specificity of Natural IgM-Mediating Reperfusion Injury	140	(3)
5. Initiation of Reperfusion Injury by a Single IgM	143	(2)
6. Limition of Ischemia-Related Antigens	145	(2)
7. Renal Ischemia-Reperfusion	147	(4)
8. Fetal Loss Syndromes	151	(2)
References	153	(6)
Formation of Bradykinin: A Major Contributor to the Innate Inflammatory Response
Kusumam Joseph and Allen P. Kaplan
Abstract	159	(1)
1. Introduction	160	(1)
2. Contact Activation	161	(5)
3. Assembly on Cell Surfaces	166	(9)
4. Activation of the Kinin Cascade: The Role of Endothelial Cells	175	(6)
5. Inhibition of Contact Activation	181	(3)
6. Inactivation of Bradykinin	184	(1)
7. Relations of the Contact Factors to Other Systems	185	(3)
8. Considerations in Human Diseases	188	(7)
References	195	(14)
Interleukin-2, Interleukin-15, and Their Roles in Human Natural Killer Cells
Brian Becknell and Michael A. Caligiuri
Abstract	209	(19)
1. Introduction	209	(2)
2. IL-2 and IL-15 Signaling	211	(4)
3. Role of IL-2 versus IL-15 in Human NK Cell Development	215	(5)
4. Low-Dose IL-2 Therapy Expands the CD56bright NK Subset	220	(2)
5. IL-2/IL-15 and NK Cell Survival	222	(2)
6. IL-2/IL-15 and NK Cell Proliferation	224	(1)
7. IL-2/IL-15 and NK Cell Apoptosis	225	(1)
8. IL-2/IL-15 and NK Cell Cytotoxicity	226	(1)
9. IL-2/IL-15 and NK Cell Cytokine Production	227	(1)
10. NK Cell-Immune Cell Interactions and Modulation by IL-2/IL-15	228	(2)
11. Conclusions	230	(2)
References	232	(9)
Regulation of Antigen Presentation and Cross-Presentation in the Dendritic Cell Network: Facts, Hypothesis, and Immunological Implications
Nicholas S. Wilson and Jose A. Villadangos
Abstract	241	(1)
1. Introduction: Dendritic Cells at the Crossroads of Immunity and Tolerance	241	(2)
2. Commonalities and Diversity in the DC Network	243	(8)
3. Antigen Presentation Pathways	251	(1)
4. Mechanisms and Regulation of Antigen Capture in DCs	252	(5)
5. Antigen Presentation by MHC II Molecules	257	(6)
6. Control of MHC II Antigen Presentation in DCs	263	(17)
7. DCs and Cross-Presentation	280	(7)
8. Conclusions and Future Directions	287	(2)
References	289	(18)
Index	307	(8)
Contents of Recent Volumes	315
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