Advances in Immunology

by Alt

• ISBN13: 9780123737083
• ISBN10: 0123737087
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-10-01
• Publisher: Elsevier Science

Summary

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Table of Contents

Contributors	p. ix
Fate Decisions Regulating Bone Marrow and Peripheral B Lymphocyte Development	p. 1
Introduction	p. 2
B Lymphocyte Development in the Bone Marrow	p. 3
Development of Immature B Cells in the Bone Marrow and Periphery	p. 21
BCR-Dependent Signaling and Fate Decisions by Bone Marrow and Peripheral Immature B Lymphocytes	p. 23
BCR Signaling During the Transitional to Mature B-Lymphocyte Transition	p. 30
Peripheral B Lymphocyte Survival: Synergy Between BCR and BAFF-R Signaling	p. 33
Development of FO and MZ Mature B Lymphocytes	p. 35
Concluding Remarks	p. 36
Acknowledgments	p. 36
References	p. 37
Tolerance and Autoimmunity: Lessons at the Bedside of Primary Immunodeficiencies	p. 51
Introduction	p. 52
PIDs Systematically Associated with Clinical AI	p. 56
PIDs Strongly Associated with Clinical AI	p. 67
PIDs that Are Mildly Associated with Clinical AI	p. 71
PIDs that Are Not Associated with AID	p. 72
Concluding Remarks	p. 73
References	p. 74
B-Cell Self-Tolerance in Humans	p. 83
Antibody Diversity	p. 84
Antibodies and Self-Tolerance	p. 85
Marginal Zone B Cells	p. 94
B-Cell Memory	p. 96
Concluding Remarks	p. 100
References	p. 102
Manipulation of Regulatory T-Cell Number and Function with CD28-Specific Monoclonal Antibodies	p. 111
Aims of this Review	p. 113
Positive and Negative Regulation of T-Cell Responses by the CD28/CTLA-4 System	p. 113
The Importance of CD28 and CTLA-4 for the Generation and Homeostasis of Treg Cells	p. 115
Manipulating the CD28 Pathway: General Considerations	p. 120
Conventional and Superagonistic mAb To the Costimulatory Receptor CD28	p. 121
In Vitro Expansion of Treg Cells with the Help of CD28-Specific mAb	p. 125
In Vivo Effects of Conventional CD28-Specific mAb	p. 126
In Vivo Effects of CD28 Superagonists: Predominance of Treg-Cell Activation	p. 128
Treatment of Autoimmune and Inflammatory Model Diseases with CD28 Superagonists	p. 132
TGN1412-A Superagonistic mAb to Human CD28	p. 135
Conclusions	p. 140
Acknowledgments	p. 141
References	p. 141
Osteoimmunology: A View from the Bone	p. 149
Opening Remarks: The Old and the New	p. 150
Osteoimmunology: A Developmental Encounter	p. 151
The TNF Superfamily: A Developmental Link Between Bone and Immune System	p. 152
IFNs: Linking Bone Homeostasis to Immunity and T Cells	p. 155
B Cells and Bone	p. 157
A Bone Quality Control of the Immune Response	p. 158
Acknowledgments	p. 160
References	p. 160
Mast Cell Proteases	p. 167
Introduction	p. 169
Expression of MC Proteases	p. 171
Genetic Organization and Regulation of Transcription	p. 176
Evolution of MC Proteases	p. 182
Protein Organization and Processing	p. 184
Three-Dimensional Structure	p. 187
Cleavage Specificity	p. 190
Interaction of MC Proteases with PGs: Implications for Storage, Activity, and Processing	p. 196
Substrates for MC Proteases	p. 203
In Vivo Function	p. 214
MC Protease Inhibitors	p. 226
Summary and Future Perspectives	p. 228
Acknowledgments	p. 229
References	p. 229
Index	p. 257
Content of Recent Volumes	p. 269
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