Advances in Immunology

by Alt

• ISBN13: 9780123743244
• ISBN10: 0123743249
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-06-11
• Publisher: Elsevier Science

Summary

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Table of Contents

Contributors	p. ix
T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other	p. 1
Introduction	p. 2
TCR Signaling Leading to Actin Cytoskeletal Remodeling	p. 4
Cytoskeletal Control of IS Formation	p. 18
Regulation of TCR-Mediated MTOC Polarization	p. 28
F-Actin-Mediated Regulation of Integrins	p. 31
Cytoskeletal Dynamics and Cell Migration	p. 36
Conclusion	p. 48
References	p. 50
HLA Class II Transgenic Mice Mimic Human Inflamamtory Diseases	p. 65
Introduction	p. 68
Expression and Function of HLA-DQ Transgenes in Mice	p. 69
HLA-DQ Transgenic Mice as Models for Human Allergies	p. 74
Expression and Function of HLA-DR Transgenic Mice	p. 77
HLA Class II Transgenic Mice Identify the Same Determinants of M. Tuberculosis-Derived Proteins as Humans	p. 84
Collagen-Induced Arthritis - Model for Human Rheumatoid Arthritis	p. 86
Experimental Autoimmune Encephalomyelitis: A Model for Multiple Sclerosis	p. 92
Spontaneous Models for Human Type I Diabetes	p. 107
Experimental Autoimmune Myasthenia Gravis	p. 111
HlA and Gluten Sensitivity-Celiac Disease and Dermatitis herpetiformis	p. 113
Relapsing Polychondritis	p. 116
Spontaneous Autoimmune Myocarditis	p. 119
Experimental Autoimmune Thyroiditis (Adapted from Kong et al., 2007)	p. 122
Experimental Autoimmune Uveitis (Adapted from Pennesi et al., 2003)	p. 125
Bacterial Superantigens and Toxic Shock Syndrome	p. 127
Concluding Remarks	p. 132
References	p. 133
Roles of Zinc and Zinc Signaling in Immunity: Zinc as an Intracellular Signaling Molecule	p. 149
Introduction	p. 150
Zn Homeostasis, Zn Transporters, and Metallothioneins in Health and Disease	p. 152
Role of Zn in the Immune Response	p. 157
Role of Zn in Mast Cells	p. 162
Zn Signaling	p. 164
Conclusion and Future Prospects	p. 167
Acknowledgements	p. 169
References	p. 169
The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses	p. 177
Introduction	p. 179
Structure, Ligands, and Expression of the SLAM-Family Receptors	p. 182
The SLAM-Family Gene Isoforms and Polymorphisms and their Role in a Genetic Predisposition for Systemic Lupus Erythematosus	p. 197
The SLAM-Associated Protein	p. 201
The Protective Role of SAP in X-Linked Lympho-Proliferative Disease	p. 207
The SAP-Related Single SH2-Domain Proteins EAT-2A and EAT-2B	p. 213
The SLAM-Family Receptors in NK Cell Responses	p. 214
The Role of the SLAM-Family in Lymphoid Cells	p. 220
The Role of the SLAM-Family on Nonlymphoid Cells	p. 228
Concluding Remarks	p. 232
References	p. 233
Conformational Plasticity and Navigation of Signaling Proteins in Antigen-Activated B Lymphocytes	p. 251
Introduction	p. 253
A Minimal Signaling Kit Couples to Proximal Transducer Enzymes	p. 254
Signal Initiation: BCR Clusters with an Open Conformation	p. 255
SLP-65: A Gateway to Intracellular Signaling Pathways	p. 259
Dynamic Regulation of the BCR-Triggered Ca[superscript 2+] Response	p. 261
Mechanism and Function of BCR-Induced Ras Activation	p. 266
Concluding Remarks	p. 272
References	p. 272
Index	p. 283
Content of Recent Volumes	p. 291
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