Advances in Immunology

by Alt

• ISBN13: 9780123743251
• ISBN10: 0123743257
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-12-12
• Publisher: Elsevier Science

Summary

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Table of Contents

Contributors	p. ix
Cis-Regulatory Elements and Epigenetic Changes Control Genomic Rearrangements of the IgH Locus	p. 1
Introduction	p. 2
The Immunoglobulin Heavy Chain Locus	p. 3
V(D)J Recombination During B-Cell Development	p. 4
Class Switch Recombination and Somatic Hypermutation	p. 7
IgH Rearrangements and Allelic Exclusion	p. 8
Accessibility Control	p. 10
IgH Locus Control Through Cis-Regulatory Elements	p. 16
Conclusions	p. 23
Acknowledgments	p. 23
References	p. 24
DNA-PK: The Means to Justify the Ends?	p. 33
Introduction	p. 34
Composition	p. 36
DNA Binding and Kinase Activation	p. 37
Structural Studies of DNA-PK	p. 38
Targets of DNA-PK's Enzymatic Activity	p. 39
DNA-PK's Autophosphorylation is Functionally Complex	p. 39
Autophosphorylation Within Two Clusters Reciprocally Regulates DNA End Access	p. 40
Further DNA-PK Autophosphorylation is Required During NHEJ	p. 43
Model of DNA-PK Activation	p. 44
End Processing to Promote End Conservation	p. 47
Does DNA-PK Regulate Dsbr Repair Pathway Choice?	p. 49
Why is DNA-PK So Abundant?	p. 50
References	p. 52
Thymic Microenvironments for T-Cell Repertoire Formation	p. 59
Introduction	p. 60
Trafficking of Developing Thymocytes	p. 64
Cortical Microenvironment	p. 68
Medullary Microenvironment	p. 71
Concluding Remarks	p. 78
Acknowledgments	p. 79
References	p. 79
Pathogenesis of Myocarditis and Dilated Cardiomyopathy	p. 95
Human Myocarditis	p. 96
The Evidence for an Autoimmune Process in Myocarditis	p. 100
Mouse Models of Myocarditis	p. 102
Role of Proinflammatory Cytokines in Myocarditis	p. 104
Role of T Helper Cells in Myocarditis	p. 104
The Divergent Role of Macrophages in Myocarditis	p. 107
Conclusions/Directions for future Research	p. 108
Acknowledgments	p. 109
References	p. 109
Emergence of the Th17 Pathway and Its Role in Host Defense	p. 115
Introduction	p. 116
Emergence of the Th17 Pathway	p. 118
Functions of the Th17-Derived Cytokines	p. 125
IL-23/IL-17-Mediated Innate Immunity	p. 128
Th17 Cells and Innate Immunity	p. 129
Th17 Cells and Acquired Immunity	p. 131
IL-23/IL-17-Mediated Responses in Specific Microbial Infections	p. 132
Closing Remarks	p. 147
References	p. 148
Peptides Presented In Vivo by HLA-DR in Thyroid Autoimmunity	p. 165
Introduction	p. 166
Natural Peptides: The Constitutive Ligands of MHC Molecules	p. 173
Natural Ligands for HLA Class II in Autoimmune Thyroid Tissue	p. 177
Concluding Remarks	p. 200
Acknowledgments	p. 201
References	p. 201
Index	p. 211
Contents of Recent Volumes	p. 217
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