Advances in Immunology

by Alt

• ISBN13: 9780123748010
• ISBN10: 0123748011
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-06-12
• Publisher: Elsevier Science

Summary

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future * Contributions from leading authorities and industry experts * Informs and updates on all the latest developments in the field

Table of Contents

Contributors	p. vii
Antigen Presentation by CD1: Lipids, T Cells, and NKT Cells in Microbial Immunity	p. 1
Introduction	p. 3
The CD1 Antigen Presentation Pathway: Chemistry, Structure, and Cell Biology	p. 3
Group I CD1: CD1a, b, and c Molecules and T Cells	p. 28
Group II CD1: CD1d-Restricted T Cells: Activation, Function, and Role in Antimicrobial Immunity	p. 35
Role of CD1d-Restricted NKT Cells in Specific Microbial Infections	p. 49
Conclusions	p. 68
Acknowledgments	p. 70
References	p. 70
How the Immune System Achieves Self-Nonself Discrimination During Adaptive Immunity	p. 95
Introduction	p. 97
Is Peripheral Immune Regulation Necessary for Self-Nonself Discrimination?	p. 99
Self-Nonself Discrimination Achieved During Thymic Negative Selection Determines How the Adaptive Immunity Is Regulated in the Periphery to Maintain Self-tolerance	p. 109
The Impact of the Conceptual Framework of the "Avidity Model" on the Development and Control of Pathogenic Autoimmunity	p. 118
Acknowledgments	p. 127
References	p. 127
Cellular and Molecular Mechanisms in Atopic Dermatitis	p. 135
Introduction	p. 136
Physiology and Immunology of Normal Skin	p. 137
Clinical Aspects of AD	p. 143
Epidemiology	p. 151
Genetics	p. 153
Pathophysiology of AD	p. 158
Animal Models of AD	p. 171
Treatment of AD	p. 201
Conclusion	p. 203
Acknowledgments	p. 204
References	p. 204
Micromanagers of Immune Cell Fate and Function	p. 227
Introduction	p. 228
miRNA Biogenesis	p. 228
miRNA Regulation of Gene Expression	p. 229
miRNA Target Genes	p. 230
miRNAs Regulate Hematopoietic Differentiation and Immune Function	p. 231
miRNA Regulation of Lymphocyte Development and Function	p. 234
miRNA Regulation of Inflammatory Responses	p. 235
Viruses Harness the miRNA Machinery	p. 235
Some Viral miRNAs Mimic Host miRNAs	p. 237
Host miRNAs also Regulate Viral Replication	p. 237
Prospects for Manipulating miRNA Function for Immunomodulatory Therapy	p. 238
Acknowledgment	p. 239
References	p. 239
Immune Pathways for Translating Viral Infection into Chronic Airway Disease	p. 245
Introduction	p. 246
Background for the Model	p. 249
cDC T Cell Immune Axis	p. 251
NKT Cell-Macrophage Immune Axis	p. 258
Summary	p. 269
Acknowledgments	p. 272
References	p. 272
Index	p. 277
Contents of Recent Volumes	p. 285
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