Advances in Ocular Toxicology

by Green, Keith; Edelhauser, Henry F.; Hackett, Robert B.; Hull, David S.; Potter, David E.

• ISBN13: 9780306456145
• ISBN10: 0306456141
• Format: Hardcover
• Copyright: 1997-06-01
• Publisher: Plenum Pub Corp

Summary

Medical College of Georgia, Augusta. Proceedings of the Fifth Congress of the International Society of Ocular Toxicology, held October 13-17, 1996, in Asheville, North Carolina. DNLM: Eye--drug effects--congresses.

Table of Contents

Welcome and Opening of Congress	1	(2)
Keith Green
1. Cytochrome P450 and Arachidonic Acid Metabolism in the Corneal Epithelium: Role in Inflammation	3	(18)
Michal Laniado Schwartzman
2. The Effects of 12(R)HETE and Its Metabolite 8(R)HHDTrE on Corneal Endothelial Function	21	(6)
Henry F. Edelhauser
K. Keven Williams
Glenn P. Holley
Wendell D. Woods
3. Protein-Thiol Mixed Disulfides and Thioltransferase in the Lens: A Review	27	(20)
Marjorie F. Lou
4. Corneal Lesions in Beagle Dogs Given Oral 5-Ethynyluracil Followed by 5-Fluorouracil	47	(8)
Robert L. Peiffer, Jr.
J. E. Dillberger
5. Corneal Damage following Continuous Infusion in Rats: Possible Explanation and Preventative Measures	55	(8)
Olivier Loget
Camelia Nanuel
Jean-Francois Le Bigot
Roy Forster
6. Ultraviolet Light-Induced Damage in Rabbit Corneal Epithelial Cells in Vitro: Protection with Absorption Filters	63	(10)
Mercedes Palmero
Alfonso Blanco
Juan L. Bellot
Nuria Alcoriza
Irene Perez
Alfredo Orts
7. The Effects of ad Libitum (AL) Overfeeding and Moderate Dietary Restriction (DR) on the Incidence of Spontaneous Corneal Dystrophy in Control Sprague-Dawley (SD) Rats	73	(8)
M. -F. Hubert
Ph. Laroque
G. Durand-Cavagna
P. Delort
K. P. Keenan
8. Barotoxic Effects on Morphology and Viability of Trabecular Cells: A Preliminary Report	81	(6)
Brenda J. Tripathi
Ramesh C. Tripathi
Junping Li
Ying Qian
W. Kosnosky
K. V. Chalam
9. Topical Fluorescein Application Can Induce Iritis and Glaucoma: An Unusual Case Report	87	(6)
Clayton Bryan
Junping Li
Brenda J. Tripathi
K. V. Chalam
Vytautas Al Pakalnis
Ramesh C. Tripathi
10. Ocular Toxicity of Sodium Diethylthiocarbamate, DDTC, in the Beagle Dog	93	(4)
Stephen Bistner
Tom Palmer
Lydia Dickrell
11. Do Therapeutic Doses of Ethambutol Cause Optic Nerve Toxicity?	97	(6)
Dinesh Talwar
Randeep Guleria
Anant Pai
S. P. Garg
12. Testing of Ocular Viscoelastics by Injection into the Rabbit Vitreous: Historical Control Data Resulting from Various Dosing Techniques	103	(4)
P. J. Upman
K. A. Herkowski
M. J. Shepherd
13. Effects of Antiviral Agents on Retinal Function in Vertebrate Retina	107	(6)
C. Luke.
P. Walter
K. U. Bartz-Schmidt
R. Brunner
K. Heimann
W. Sickel
14. Experimental Implantation of Devices for Electrical Retinal Stimulation in Rabbits: Preliminary Results	113	(8)
Peter Walter
Peter Szurman
Ralf Krott
Uta Baum
Karl-Ullrich Bartz-Schmidt
Klaus Heimann
15. Nitric Oxide in Ocular Inflammation	121	(12)
J. B. Allen
M. C. McGahan
L. N. Fleisher
G. J. Jaffe
T. Keng
C. T. Privalle
16. Role of Nitric Oxide in Vascular Dysfunction Associated with Ocular Diseases	133	(18)
Ronald G. Tilton
17. Effects of the Inhibition of Nitric Oxide Synthase and Lipoxygenase on the Development of Endotoxin-Induced Uveitis	151	(8)
Juan L. Bellot
Nuria Alcoriza
Mercedes Palmero
Alfonso Blanco
Rafael Espi
Claude Hariton
Alfredo Orts
18. Evaluation of Two Rabbit Ocular Implantation Models Using Polymethylmethacrylate Intraocular Lenses	159	(10)
John N. Norton
Robert B. Hackett
Robert J. Munger
19. Characterization of Immortalized Lens Epithelial Cells as a Potential in Vitro Alternative Model for the Cellular Toxicity and the Efficacy Evaluations of Ocular Drug Candidates	169	(12)
C. Yao.
D. Wampler
Guo-Tung Xu
D. Crouch
D. Rodeheaver
R. Hackett
J. Veltman
20. Immortalization and Characterizations of Rabbit Corneal Epithelial Cell Lines as Potential in Vitro Alternative Models for Evaluating the Cellular Toxicity of Ocular Drug Candidates	181	(12)
C. Yao
D. Wampler
K. Hall
D. Crouch
R. Hackett
J. Veltman
D. Rodeheaver
21. Comparison of Some in Vitro Measurements of Membrane Damage to Corneal Epithelial Cells	193	(10)
Steven S. Matsumoto
Josephine W. Cheng
David C. Rupp
Claude B. Anger
Michael E. Stern
22. Computer-Assisted Evaluation of Iris Color Changes in Primate Toxicity Studies	203	(4)
W. H. Bee
F. Vogel
R. Korte
23. Workshop on in Vitro Versus in Vivo Models for Ocular Toxicity Testing	207	(54)
Henry F. Edelhauser
Keith Green
24. Toxicity Testing for Ocular Drug Products	261	(8)
Javier Avalos
Abigail Jacobs
Jonathan K. Wilkin
Participants	269	(4)
Index	273