Advances in Optical Imaging for Clinical Medicine

by Iftimia, Nicusor; Brugge, William R.; Hammer, Daniel X.

• ISBN13: 9780470619094
• ISBN10: 0470619090
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-02-15
• Publisher: Wiley

Summary

This book provides students, teachers, researchers and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.

Author Biography

Nicusor Iftimia is leader of the Advanced Microscopy and Image Guided Interventions Group at Physical Sciences, Inc. in Andover, Massachusetts. He has been awarded several NIH and DoD grants to conduct cutting edge research in biomedical optics imaging for cancer diagnosis and therapy guidance. He has published over forty peer-reviewed journal papers, is the author of several book chapters, and a co-inventor of more than ten patents. William R. Brugge is Director of the Gastrointestinal Endoscopy Unit at the Massachusetts General Hospital and Professor of Medicine at Harvard Medical School. Dr. Brugge pioneered the use of endoscopic ultrasound imaging in the diagnosis and staging of gastrointestinal malignancies, particularly early malignancies of the pancreas. Daniel X. Hammer is leader of the Biomedical Imaging Group at Physical Sciences, Inc. in Andover, Massachusetts. He specializes in the development of innovative biomedical optical instruments, conducting international award-winning research in the area of ophthalmology and adaptive optics. He has published more than forty peer-reviewed journal papers and is a co-inventor of more than ten patents.

Table of Contents

Introduction

Traditional Imaging Modalities in Clinical Medicine

Introduction

Diagnostic imaging technologies

Imaging for radiation therapy planning

Image-guided radiation therapy

Conclusions

Current imaging approaches and further imaging needs in clinical medicine: A clinician perspective

Ophthalmic Imaging

Imaging of the Gastrointestinal Mucosa

Cardioimaging

Neuroimaging: current technologies and further needs

Advances in Retinal Imaging

Introduction

Prevalent Retinal Diseases

Traditional Imaging Technologies

Advanced Imaging Technologies

Imaging Beyond Disease Detection

Conclusion

Confocal Microscopy of Skin Cancer

Introduction

Imaging of Normal Skin In Vivo

Imaging of Cutaneous Neoplasms In Vivo - correlation with dermoscopy and histopathology

Mosaicing of Excised Skin Ex Vivo

Intra-operative Mapping of Surgical Margin

Challenging Cases

Future perspectives

Acknowledgements

High-resolution optical coherence tomography imaging in gastroenterology

Introduction

Optical Coherence Tomography

Clinical Gastrointestinal Imaging

Future Directions

Conclusions

High-resolution confocal endomicroscopy for gastrointestinal cancer detection

Introduction and motivation

Conventional confocal endomicroscopy

Dual-axis confocal endomicroscopy

Toward larger fields of view?mosaicing

Summary and future directions

High-resolution Optical Imaging in Interventional Cardiology

Introduction

Current Invasive Imaging Modalities In interventional Cardiology

High-resolution optical coherence tomography imaging in

Current Limitations of OCT

Future developments

Conclusion

Fluorescence Lifetime Spectroscopy in Cardio and Neuroimaging

Introduction

Fluorescence lifetime spectroscopy in tissue characterization

Time-Resolved Fluorescence Spectroscopy - Instrumentation

Time-Resolved Fluorescence Spectroscopy - Data Analysis Methods

Atherosclerotic plaque

Primary brain tumors

Concluding remarks

Acknowledgments

References

Advanced Optical Methods for Functional Brain Imaging

Introduction

Optical technologies for noninvasive neural activity mapping

Optical imaging of the depth-resolved functional activity in cortex

Novel approaches

Conclusions

Advances in Optical Mammography

Introduction

Structure and Physiology of human female breast: an optical perspective

Optical Imaging breast technology

In-vivo optical properties of healthy breast

Optical imaging in breast oncology

Multimodality Approaches

Summary

Photoacoustic Tomography

Introduction

Photoacoustic Theory

PAT Imaging Methods

Photoacoustic Wave Equations

Finite Element and Model-Based PAT Reconstruction Methods

Quantitative PAT

PAT Imaging Instrumentation

In vivo Applications

References

Optical Imaging and Measurement of Angiogenesis

Introduction

Angiogenesis ? A brief overview

Potential clinical applications

Optical techniques to image angiogenesis

Other modalities

Conclusions

High-resolution Phase Contrast Optical Coherence Tomography for Functional Biomedical Imaging

Introduction

Time Domain Phase Sensitive Interferometry

Spectral Domain Phase Sensitive Interferometry

Applications of differential phase contrast imaging

Comparison of time domain and spectral domain phase-sensitive systems

Conclusion

Polarization imaging

Introduction

Polarization analysis

Polarization microscopy

Biomedical applications

Other polarization imaging applications

Conclusions

Nanotechnology Approaches for Contrast Enhancement in Optical Imaging and Disease Targeted Therapy

Introduction

Nanotechnology-based contrast agents for optical imaging and targeted therapy

Enhanced contrast optical imaging using functionalized nonoprobes

Nanotechnology-based drug delivery systems for disease-targeted therapy and tissue

Conclusions

Molecular probes for optical contrast enhancement of gastrointestinal cancers

Introduction

DNA Microarrays for Target Identification

Phage Display

Potential Targets and Possible Pitfalls

Probe Design

Conclusion

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