Advances in Schizophrenia Research 2009

by Gattaz, Wagner F.; Busatto, Geraldo

• ISBN13: 9781441909121
• ISBN10: 1441909125
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-12-01
• Publisher: Springer Verlag

Summary

Schizophrenia stands a major psychiatric mystery: devastating to patients and families, resistant to treatment, burdened by stigma, causes unknown. As interest and research in the disorder continue worldwide, new sources for comprehensive review of cutting-edge studies are of growing importance. The leadoff volume of Advances in Schizophrenia Research 2009 fills this need with welcome innovation and scientific rigor.

Table of Contents

Epidemiology And Risk Factors
Incidence and Outcome of Schizophrenia Across the Globe	p. 3
Gene-Environment Interactions for Searchers: Collaboration Between Epidemiology and Molecular Genetics	p. 19
The Natural History of the Course and Outcome of Schizophrenia	p. 51
Impact of Contextual Environmental Mechanisms on the Incidence of Schizophrenia and Other Psychoses	p. 67
Pathophysiology
Disinhibition of Prefrontal Cortex Neurons in Schizophrenia	p. 99
Brain Anatomical Abnormalities in Schizophrenia: Neurodevelopmental Origins and Patterns of Progression over Time	p. 113
The Neuropathology of Schizophrenia: Central Role for the Hippocampus?	p. 149
Molecular Neuroimaging, Pathophysiological Mechanisms, and Drug Discovery	p. 167
Genetics
Animal Models of Schizophrenia: Focus on Hippocampal Disruption of Dopamine System Regulation	p. 175
Genetic and Proteomic Studies in Schizophrenia	p. 193
Neurogenetic Risk Mechanisms of Schizophrenia; An Imaging Genetics Approach	p. 219
Progress in Genetic Studies of Schizophrenia	p. 233
Psychopathology, Cognition, Outcome
Prediction of Psychosis Through the Prodromal Syndrome	p. 251
Schizophrenia as a Cognitive Disorder: Recent Approaches to Identifying its Core Cognitive Components to Aid Treatment Development	p. 267
Cognitive and Social Processes in Psychosis: Recent Developments	p. 283
The Impact of Early Intervention in Schizophrenia	p. 299
The Cross-Sectional and Longitudinal Architecture of Schizophrenia: Significance for Diagnosis and Intervention?	p. 317
Schizophrenia and Other Psychotic Disorders: Boundaries and Similarities
Continua or Classes? Vexed Questions on the Latent Structure of Schizophrenia	p. 333
Integrating the Epidemiology and Pathogenesis of Schizophrenia from the Street to the Striatum: Integrating the Epidemiology and Pathogenesis of Schizophrenia	p. 357
Cannabis: A Clue or a Distraction in the Search for 'Causes' of Psychosis?	p. 367
The 'Totality' of Psychosis: Epidemiology and Developmental Pathobiology	p. 377
Treatment
Comparative Efficacy and Safety of First-and Second-Generation Antipsychotics in the Treatment of Schizophrenia: Facts and Fiction	p. 389
Long-Acting Antipsychotic Medication and the Outcome of Schizophrenia	p. 403
Modern Community Care Strategies for Schizophrenia Care: Impacts on Outcome	p. 417
Does Stigma Impair Treatment Response and Rehabilitation in Schizophrenia? The "Contribution" of Mental Health Professionals	p. 429
Treatment of Schizophrenia: Discussion	p. 441
Index	p. 447
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