List of contributors | p. XIII |
Advances | |
Present and potential future adjuvant issues in high-grade astrocytic glioma treatment | |
Abstract | p. 4 |
Introduction | p. 5 |
Natural resistance of migrating malignant glioma cells to apoptosis (radiotherapy and chemotherapy) | p. 6 |
Patterns of cell death | p. 8 |
Autophagy: a potential Trojan horse for malignant gliomas | p. 11 |
Therapeutic benefits of temozolomide | p. 13 |
Local therapies for glioblastomas | p. 15 |
Ongoing clinical trials for glioblastomas | p. 16 |
Growth factor receptor inhibitors | p. 17 |
PI3K/Akt, mTOR and NF-kB inhibitors | p. 17 |
Matrix metalloproteinase (MMP) inhibitors (MMPI) | p. 18 |
Angiogenesis targeting | p. 19 |
Cellular and vaccination therapies | p. 20 |
Gene therapy | p. 20 |
Reducing malignant glioma cell motility in order to restore pro-apoptotic drug sensitivity | p. 20 |
The sodium pump constitutes a potential target to combat malignant gliomas | p. 21 |
The sodium pump | p. 22 |
Cardiotonic steroids: ligands of the sodium pump | p. 24 |
The sodium pump is involved in cancer cell proliferation, migration and death | p. 24 |
Brain tumor stem cells a potential target to combat malignant gliomas | p. 26 |
Conclusions | p. 27 |
References | p. 28 |
Deep brain stimulation for psychiatric disorders - state of the art | |
Abstract | p. 37 |
Introduction | p. 38 |
History of deep brain stimulation | p. 39 |
Principles of DBS | p. 40 |
Neurobiology of depression and OCD | p. 41 |
Neurobiology of depression | p. 41 |
Neurobiology of OCD | p. 42 |
Studies of DBS and psychiatric disorders | p. 43 |
Problems in target selection | p. 43 |
Targets in depression | p. 43 |
Targets in OCD | p. 46 |
Safety and advantages of DBS | p. 47 |
Ethical aspects and standards in DBS | p. 51 |
Ethical considerations | p. 51 |
The path towards mandatory standards for DBS in psychiatric disorders | p. 52 |
Conclusions | p. 53 |
The future of DBS | p. 54 |
References | p. 54 |
Standards | |
High flow extracranial to intracranial vascular bypass procedure for giant aneurysms: indications, surgical technique, complications and outcome | |
Abstract | p. 61 |
Introduction | p. 62 |
Surgical technique | p. 67 |
Cranial exposure | p. 69 |
Cervical exposure | p. 70 |
Saphenous vein exposure | p. 71 |
Pre auricular tunnel | p. 72 |
Anastamoses | p. 73 |
Distal anastamosis | p. 73 |
External carotid anastamosis | p. 74 |
Closure and post operative care | p. 77 |
Discussion | p. 77 |
Comparison of outcomes | p. 77 |
Choosing the type of graft | p. 78 |
Long term patency of grafts | p. 79 |
Ischaemic complications | p. 79 |
Anticoagulation related morbidity | p. 81 |
Conclusion | p. 81 |
References | p. 81 |
Decompression for Chiari type I-malformation (with or without syringomyelia) by extreme lateral foramen magnum opening and expansile duraplasty with arachnoid preservation: comparison with other technical modalities (Literature review) | |
Abstract | p. 86 |
Introduction/Definition | p. 86 |
Generalities | p. 87 |
Chiari type I-malformation pathophysiology | p. 87 |
Syringomyelia pathophysiology | p. 88 |
Neuro-imaging | p. 88 |
Overview of the various technical modalities | p. 90 |
Decompression with extreme lateral foramen magnum opening and expansile duraplasty with arachnoid preservation | p. 91 |
Personal series | p. 91 |
Technical description | p. 93 |
Discussion from literature review | p. 96 |
Chiari type I malformation without syringomyelia | p. 97 |
Chiari type I malformation with syringomyelia | p. 100 |
Conclusion | p. 105 |
Acknowledgements | p. 106 |
References | p. 106 |
Vagal nerve stimulation - a 15-year survey of an established treatment modality in epilepsy surgery | |
Abstract | p. 111 |
Introduction | p. 112 |
Mechanism of action | p. 115 |
Clinical efficacy and safety | p. 120 |
Randomised controlled trials | p. 120 |
Prospective clinical trials with long-term follow-up | p. 122 |
Prospective clinical trials in children | p. 122 |
Clinical trials in specific patient groups | p. 123 |
Generalized epilepsy | p. 123 |
Status epilepticus | p. 123 |
Lennox-Gastaut syndrome | p. 124 |
Other patient groups | p. 124 |
Safety, side effects and tolerability | p. 125 |
Perioperative side effects | p. 125 |
Ramping up and long-term stimulation | p. 126 |
Miscellaneous side effects | p. 131 |
MRI/3 Tesla MRI | p. 131 |
Teratogenic effects of VNS | p. 134 |
Discussion | p. 135 |
Conclusion | p. 137 |
References | p. 137 |
Surgical anatomy and surgical approaches to the lateral ventricles | |
Abstract | p. 148 |
Embryology | p. 149 |
Anatomy | p. 152 |
The cavity of the lateral ventricle | p. 152 |
The walls of the lateral ventricle | p. 152 |
The anterior frontal horn | p. 152 |
The body of the frontal horn or central part of the LV | p. 154 |
The atrium | p. 155 |
The occipital diverticulum (or occipital horn) | p. 155 |
The temporal horn | p. 157 |
The interventricular foramen | p. 157 |
Choroid plexus and CSF circulation | p. 157 |
Arterial vasculature of the VL | p. 158 |
Anterior choroid artery (AChA) | p. 159 |
Posterior choroid artery (PChA) | p. 160 |
The veins of the lateral ventricles | p. 160 |
Relationships of the lateral ventricles | p. 163 |
Cortical eloquent areas | p. 163 |
Distances between cortex and ventricular cavity | p. 164 |
Relationships with the cortical sulci | p. 166 |
Relationships with white matter fascicles | p. 167 |
Surgical approaches | p. 171 |
General considerations | p. 171 |
Tumors of the frontal horn | p. 173 |
Transventricular transfrontal approach | p. 173 |
Anterior transcallosal approach | p. 176 |
Tumors of the temporal horn | p. 179 |
Tumors of the ventricular atrium | p. 181 |
Transparietal route (qualified through P2) | p. 181 |
Posterior transparietal approach (qualified through P1) | p. 182 |
Interhemispheric parasplenial approach | p. 182 |
Variants of atrium tumors | p. 184 |
Tumors of the atrium extending to the frontal horn | p. 184 |
Tumors of the atrium extending to the temporal horn | p. 184 |
Tumors of the atrium extending to the occipital horn | p. 184 |
Conclusion | p. 184 |
Annexe | p. 185 |
References | p. 185 |
Author index | p. 189 |
Subject index | p. 201 |
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