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9780198569220

Aging of the Genome The Dual Role of DNA in Life and Death

by
  • ISBN13:

    9780198569220

  • ISBN10:

    019856922X

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2007-03-29
  • Publisher: Oxford University Press
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Summary

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

Author Biography


Jan Vijg is Professor at the Buck Institute for Age Research in Novato, California, USA

Table of Contents

Preface
Introduction
The Logic of Aging
Genome Structure and Function
Genome Maintenance
Genome Instability and Accelerated Aging
The Aging Genome
From Genome to Phenome
A Genomic Limit to Life?
References and Glossary
Literature
References
Table of Contents provided by Publisher. All Rights Reserved.

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