AIDS Pathogenesis

by Schuitemaker, Henneke; Miedema, Frank

• ISBN13: 9780792361961
• ISBN10: 0792361962
• Format: Hardcover
• Copyright: 2000-04-01
• Publisher: Kluwer Academic Pub

Summary

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.

Table of Contents

HIV-1 transmission	1	(18)
A.B. van't Wout
R.A. Koup
W.A. Paxton
Primary HIV infection	19	(22)
A. Carr
D. Cooper
Biological variability of HIV-1	41	(14)
J. Albert en M. Koot
T-cell dynamics and renewal in HIV-1 infection	55	(10)
K.C. Wolthers
D.R. Clark
Long-term non-progressive HIV infection	65	(12)
S. Buchbinder
E. Vittinghoff
Cytotoxic T lymphocytes in HIV-1 infection	77	(22)
M.R. Klein
S.H. van der Burg
B. Autran
Mechanisms and in-vivo significance of HIV-1 neutralisation	99	(34)
P.W.H.I. Parren
D.R. Burton
Q.J. Sattentau
Suppression of primate immunodeficiency lentiretro-viruses by CD8+ T-cell-derived soluble factors	133	(22)
P. Lusso
Opportunistic infections	155	(22)
J. Helwel-Larsen
T.L. Benfield
J.D. Lundgren
AIDS-related non-Hodgkin's lymphomas	177	(32)
M.J. Kersten
M.H.J. van Oers
Pathogenesis of Kaposi's sarcoma	195	(14)
T.F. Schulz
AIDS dementia complex	209	(12)
P. Portegies
R.H. Enting
Anti-retroviral therapy and resistance to anti-retroviral drugs	221	(22)
J.M.A. Lange
J.S.G. Montanes
Prognostic markers and immunological reconstistution during HIV-1 infection	243	(18)
M.Th.L. Roos
N.G. Pakker
P.Th.A. Schellekens
HIV-viral load	261	(12)
F.de Wolf
I. Spijkerman
The SCID-hu mouse: an in-vivo model for HIV-1 infection in humans	273	(6)
K. Kaneshima
Non-human primate models for HIV-1 infection	279
N.L. Letvin