AIDS Update 2009

by Stine, Gerald J., Ph.D.

• ISBN13: 9780073527598
• ISBN10: 0073527599
• Edition: 18th
• Format: Paperback
• Copyright: 2008-12-11
• Publisher: McGraw-Hill/Dushkin

Summary

AIDS UPDATE 2009 presents a balanced review of current research and information on HIV infection, HIV disease, and AIDS. AIDS UPDATE 2009 places discussion within a biological, medical, and social framework, helping readers more fully understand this devastating pandemic..

Table of Contents

Contents

About the Authoriii

A Quarter Century of AIDS and Counting: A Humanitarian Crisisix

AIDS UPDATE 2009xvi

Prefacexviii

Introduction: Histories of Global Pandemics, AIDS, Its Place in History, Overview of HIV/AIDS, International AIDS Conferences and Means of Remembering the AIDS Quilt, Candlelight Memorial, and World AIDS Day

Three Words Echo Around the World: AIDS Crisis Worsens!

History of Global Pandemics and Epidemics

Fear, Ignorance and Condemnation: Who Is to Blame?

Imagine a World Without AIDS

Overview of HIV/AIDS

AIDS: A Unique Disease

AIDS: A Cause of Death

Another Anniversary

A New Anniversary

International AIDS Conferences

Means of Remembering

The

5th Candlelight Memorial

Walking to Change the Course of the HIV/AIDS Epidemic United States

Bicycle Riding to Change the Course of the HIV/AIDS Epidemic United States

World AIDS Day: An International Day of Coordinated Action: A Time to Recharge and Reconnect

The World Health and UNAIDS Organizations

The Future

National AIDS Hotlines

Useful Internet Addresses

1AIDS: Defining the Disease and Finding Its Cause

The New Millennium

AIDS: A Disease or a Syndrome?

First Reaction to AIDS: Denial

What Causes AIDS?

How Does HIV Cause AIDS?

The Centers for Disease Control and Prevention Reports

Discovery of the AIDS Virus

Defining the Illness: AIDS Surveillance

Summary

Review Questions

2What Causes AIDS: Origin of the AIDS Virus

The Cause of AIDS: The Human Immunodeficiency Virus (HIV)

Evidence That HIV Causes AIDS

Origin of HIV: The AIDS Virus

Summary on the Origin of HIV

Summary

Review Questions

3Biological Characteristics of the AIDS Virus

Viruses Need a Host Cell in Order to Reproduce

Viruses Are Parasites

Viruses Specific to Cell Type

Retroviruses

Description of HIV; How It Attaches to a Host Cell and Buds Out of the Cell

Human Immunodeficiency Virus (HIV): Its Life Cycle

The HIV Life Cycle

How HIV Escapes the Infected Cell

Basic Genetic Structure of Retroviral Genomes

Genetic Revolution

Formation of Genetic Recombination in HIV

Distinct Genotypes (Subtypes/Clades) of HIV-1 Worldwide Based on ENV and GAG Proteins

Summary

Review Questions

4Anti-HIV Therapy

Anti-HIV Therapy

HIV Eradication Update

08

Antiretroviral Therapy (ART) Drugs with FDA Approval

The HIV Medicine Chest: ART Drugs Receiving FDA Approval

FDA-Approved Nucleoside/Non-Nucleoside Analog Reverse Transcriptase Inhibitors and Protease Inhibitors

Use of Non-Nucleoside Analog Reverse Transcriptase Inhibitors

FDA-Approved Protease Inhibitors

Protease Inhibitors

Entry Inhibitors and Problems

Integrase Inhibitors

Development and Selection of HIV Drug-Resistant Mutants

Development of HIV Drug Resistance to Protease Inhibitors

How Combination Drug Therapy Can Reduce the Chance of HIV Drug Resistance

HIV Treatment Regimen Failure

Viral Load: Its Relationship to HIV Disease and AIDS

Medical Complications Associated with Anti-HIV Drug Therapies (ART)

The Smart Trial Was Cancelled onJanuary

Novel Drugs

Disclaimer

Summary

Some AIDS Therapy Information Hotlines

Review Questions

The Immunology of HIV Disease/AIDS

The Immune System

Human Lymphocytes: T Cells and B Cells

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