Allergy Frontiers

by Pawankar, Ruby; Holgate, Stephen T.; Rosenwasser, Lanny J.

• ISBN13: 9784431883142
• ISBN10: 4431883142
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-03-30
• Publisher: Springer Verlag

Summary

The prevalence of asthma and other allergic diseases is on the rise worldwide, with a marked impact on quality of life and socioeconomics. Allergy Frontiers comprises six volumes, each dedicated to a specific aspect of the disease to reflect the multidisciplinary character of the field and its explosive growth. Included are reviews by world-renowned scientists from Europe, North and South America, Australia, Japan, other parts of Asia, and South Africa.In this second volume of the series, the pathomechanisms of various allergic diseases and their classification are given, including such important special aspects as allergy and bone marrow, allergy and the nervous system, and allergy and mucosal immunology. This book serves as a valuable tool for scientists and as a practical guide for clinicians working in the fields of allergy, asthma, and immunology.

Table of Contents

Classification and Pathomechanisms
Basic Aspects of Allergy and Hypersensitivity Reactions	p. 3
Pathogen Recognition and New Insights into Innate Immunity	p. 19
New Nomenclature and Clinical Aspects of Allergic Diseases	p. 31
IgE and the High-Affinity Receptor, FceRI: The IgE-CD23 Interaction	p. 43
Superantigens and Allergic Disease	p. 59
Immune Complexes: Normal Physiology and Role in Disease	p. 79
What Is New About Eosinophil Activation in Asthma and Allergic Disease	p. 95
Mast Cell and Basophils: Interaction with IgE and Responses to Toll like Receptor Activators	p. 113
T Cells in Allergic Disease	p. 135
Role of NKT Cells in the Regulation of Ongoing Type 2 Immune Response	p. 151
CD8+ T Cells Play a Key Role in the Development of Allergic Lung Inflammation	p. 167
Neutrophils and Their Mediators in Asthma and Allergic Disease	p. 179
Dendritic Cells, Macrophages and Monocytes in Allergic Disease	p. 195
Function of Dendritic Cell Subsets in Allergic Disease	p. 209
Epithelial Cell-Mesenchymal Interaction, Epithelial-Leukocyte Interaction and Epithelial Immune-Response Genes in Allergic Disease	p. 231
Role of Epidermal Growth Factor Receptor Cascade in Airway Epithelial Regulation of Mucus Production	p. 249
Epithelial Cell Innate Responses to Rhinovirus Infection	p. 267
The Role of Platelets in Allergy	p. 285
Expression and Function of Siglec-8 in Human Eosinophils, Basophils, and Mast Cells	p. 297
Effects of Nitric Oxide on Mast Cells: Production, Functions, and Mechanisms of Action	p. 315
Histamine and Its Receptors	p. 329
Adenosine: Its Contribution to Our Understanding in Airway Inflammation	p. 357
Airway Smooth Muscle Dysfunction in Asthma	p. 377
Genetic Variation in Cytokines, Asthma, and Atopy: The Role of IL-4/IL-13 Pathway Polymorphisms	p. 401
Allergy and the Bone Marrow: Transmigration Pathways of Hemopoietic Progenitor Cells from the Bone Marrow	p. 421
Hemopoietic Mechanisms in Allergic Rhinitis and Asthma	p. 433
Allergy and the Nervous System
Neuroanatomy of the Airways	p. 457
Biology of Neurotrophins, Neuropeptides, and Muscarinic Receptors in Asthma	p. 469
Neural Regulation of the Immune Response	p. 493
Neuroregulation of Mucosal Vasculature	p. 515
Allergy and Mucosal Immunology
Mucosal Immunity: from Allergy to Coeliac Disease	p. 529
Mucosa-Associated Lymphoid Tissue and Dynamics of Lymphoid Cells in the Five Different Compartments in Allergic Diseases	p. 563
Index	p. 603
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