Alzheimer's Disease Advances in Etiology, Pathogenesis and Therapeutics

by Iqbal, Khalid; Sisodia, Sangram S.; Winblad, Bengt

• ISBN13: 9780471521761
• ISBN10: 0471521760
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-08-24
• Publisher: WILEY

Summary

Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

Author Biography

Khalid Iqbal is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, published by Wiley.

Sangram S. Sisodia is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, published by Wiley.

Bengt Winblad is the editor of Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics, published by Wiley.

Table of Contents

List of Contributors	xii
Dedications	xxvi
Scientists Honored for Pioneering Research	xxix
Preface	xxxv
Acknowledgments	xxxvi
I. EPIDEMIOLOGY AND RISK FACTORS	1	(30)
The Transition from Normal Functioning to Dementia in the Aging Population	3	(8)
Laura Fratiglioni
Brent Small
Bengt Winblad
Lars Backman
Epidemiology of Alzheimer's Disease and Dementia: Advances and Challenges	11	(12)
Robert Katzman
Epidemiology of Dementia in Down's Syndrome	23	(8)
Nicole Schupf
II. GENETICS	31	(66)
A Genomic Search for Alzheimer's Disease Genes	33	(1)
Jonathan L. Haines
L. Renee Bailey
Janet M. Grubber
Dale Hedges
Jenifer L. Hall
Sandra West
Leonard Santoro
Beth Kemmerer
Anne M. Saunders
Allen D. Roses
Gary W. Small
William K. Scott
P. Michael Conneally
Jeffery M. Vance
Margaret A. Pericak-Vance
Candidate Genes Showing No Evidence of Association with Alzheimer's Disease: Results of the NIMH-AD Genetics Initiative	33	(20)
Lars Bertram
Deborah Blacker
Adam S. Crystal
Jennifer Jones
Devon Keeney
Laura A. MacKenzie-Ingano
Kristina Mullin
Sanjay Basu
Stephen Yhu
Melvin McInnis
Rodney C. P. Go
Aleister J. Saunders
Rudolph E. Tanzi
Familial Alzheimer's Disease with Spastic Paraparesis Associated with a Mutation at Codon 261 of the Presenilin 1 Gene	53	(8)
Martin R. Farlow
Jill R. Murrell
Frederick W. Unverzagt
Michael Phillips
Masaki Takao
Christine Hulette
Bernardino Ghetti
Genetic Analysis of the Presenilin Pathway in Drosophila	61	(10)
Izhar Livne-Bar
Gabrielle L. Boulianne
Molecular Genetics and Transgenic Modeling of the Tauopathies	71	(16)
Jada Lewis
Matt Baker
Marjon Van Slegtenhorst
Mike Hutton
Regulation of Four-repeat tau Expression: Interactions between Exon and Intron Splicing Regulatory Sequences	87	(10)
Ian D'Souza
Gerard D. Schellenberg
III. DIAGNOSIS AND CLINICAL COURSE	97	(232)
Preclinical Prediction of AD: Relation Between Neuropsychological and Neuroimaging Findings	99	(12)
Marilyn S. Albert
Ronald J. Killiany
Keith Johnson
Rudolph E. Tanzi
Kenneth Jones
Neuropsychological Detection of Preclinical Alzheimer's Disease: Results of a Neuropathological Series of `Normal' Controls	111	(12)
Kathleen A. Welsh-Bohmer
Christine Hulette
Donald Schmechel
James Burke
Ann Saunders
Potentially Reversible Conditions in Memory Clinic Patients	123	(6)
Anne-Mette Hejl
Peter Hogh
Gunhild Waldemar
The Alzheimer's Disease Centers' Neuropsychological Database Initiative: A Resource for Alzheimer's Disease Prevention Trials	129	(12)
Michael Grundman
Hyun T. Kim
David Salmon
Martha Storandt
Glenn Smith
Steven Ferris
Richard Mohs
Jason Brandt
Rachelle Doody
Kathleen Welsh-Bohmer
Judith Saxton
Kathy Saine
Frederick Schmitt
Paula Ogrocki
Nancy Johnson
Diane Howieson
Michelle Papka
Joanne Green
Anthony Gamst
Walter Kukull
Leon J. Thal
Mild Cognitive Impairment: Transition from Aging to Alzheimer's Disease	141	(12)
Ronald C. Petersen
Brain Functional Imaging in Early and Preclinical Alzheimer's Disease	153	(12)
Agneta Nordberg
Vesna Jelic
Eva Arnaiz
Bengt Langstrom
Ove Almkvist
Amyloid, PHF-tau, Ubiquitin and Synaptic Markers in the Progression of Alzheimer's Disease: Immunochemical Analyses of Frontal Cortex from Prospectively Studied Elderly Humans	165	(16)
D. S. Wang
E. Cochran
D. Bennett
E. Mufson
C. Eckman
D. W. Dickson
Imaging the Consequences of Alzheimer's Disease Pathology	181	(12)
Yaakov Stern
Scott Small
Influence of apoE Genotype and PET Brain Imaging on Preclinical Prediction of Alzheimer's Disease	193	(12)
Gary W. Small
Linda M. Ercoli
Daniel H.S. Silvermann
S.-C. Huang
Susan Y. Bookheimer
Helen Lavretsky
Karen Miller
Prabha Siddarth
John C. Mazziotta
Ann M. Saunders
Margaret A. Pericak-Vance
Allen D. Roses
Jorge R. Barrio
Michael E. Phelps
Overview of Vascular Dementia	205	(14)
William R. Markesbery
Clinical and Imaging Characteristics of Vascular Dementia in a Memory Clinic	219	(10)
F. Pasquier
X. Douay
C. Delmaire
F. Lebert
J. P. Pruvo
MRI of Entorhinal Cortex and Hippocampus in Alzheimer's Disease, Subcortical Ischemic Vascular Dementia and Mixed Dementia	229	(8)
N. Schuff
A. T. Du
D. Amend
Y. Y. Hsu
M. P. Laakso
W. Jagust
H. C. Chui
M. W. Weiner
Olfactory Function and Event-related Potentials in Alzheimer's Disease	237	(16)
Claire Murphy
Charlie D. Morgan
Phenotypic Differences in Cholinergic Markers within the Nucleus Basalis in Individuals with Mild Cognitive Impairment	253	(12)
Elliott J. Mufson
Michele Gilmor
Shuang Y. Ma
Alan I. Levey
Jeffrey H. Kordower
Evaluating CNS Biomarkers for Alzheimer's Disease	265	(10)
John H. Growdon
CSF Markers for Early Alzheimer's Disease	275	(10)
Kaj Blennow
Pia Davidsson
Eugeen Vanmechelen
CSF-Phospho-tau (181P) as a Promising Marker for Discriminating Alzheimer's Disease from Dementia with Lewy Bodies	285	(8)
E. Vanmechelen
E. Van Kerschaver
K. Blennow
P. P. De Deyn
D. Galasko
L. Parnetti
C. J. M. Sindic
H. Arai
M. Riemenschneider
H. Hampbel
H. Pottel
A. Valgaeren
F. Hulstaert
H. Vanderstichele
Increased Levels of a Minor Glycoform of Acetylcholinesterase in Alzheimer's Disease Brain and Cerebrospinal Fluid	293	(10)
Javier Saez-Valero
Su San Mok
Lisa Fodero
Alberto Marcos
Maria-Sagrario Barquero
Catriona McLean
David H. Small
Plasma β-Amyloid as a Surrogate Genetic Marker in Late-onset Alzheimer's Disease	303	(8)
Nilufer Ertekin Taner
Neill Graff-Radford
Linda H. Younkin
Christopher Eckman
Jennifer Adamson
Daniel J. Schaid
John Blangero
Michael Hutton
Steven G. Younkin
Levels of Total and Deposited Aβ are Correlated with Dementia	311	(8)
S. Parvathy
J. Naslund
V. Haroutunian
J. D. Buxbaum
What Should We Tell Patients Attending a Memory Disorders Clinic About Their Diagnosis?	319	(10)
Conor P. Maguire
Rebecca M. Slinn
IV. MECHANISMS OF NEURODEGENERATION	329	(12)
Innate Immunity, Autotoxicity and Degenerative Neurologies	331	(10)
Patrick L. McGeer
Koju Yasojima
Edith G. McGeer
Neuroinflammatory Responses in the Alzheimer's Disease Brain Promote the Oxidative Post-translational Modification of Amyloid Deposits	341	(22)
Craig S. Atwood
Xudong Huang
Robert D. Moir
Mark A. Smith
Rudolph E. Tanzi
Alex E. Roher
Ashley I. Bush
George Perry
Plasma Antioxidants and Oxidative DNA Damage in Lymphocytes from Normal Aged People and Alzheimer's Disease Patients	363	(8)
Patrizia Mecocci
Maria Cristina Polidori
Tiziana Ingegni
Paola Mattioli
Antonio Cherubini
Marco Catani
Roberta Cecchetti
Umberto Senin
Oxidative Damage and Antioxidant Responses in Alzheimer's Disease	371	(8)
George Perry
Akihiko Nunomura
Jesus Avila
Mar Perez
Catherine A. Rottkamp
Craig S. Atwood
Xiongwei Zhu
Gjumrakch Aliev
Adam D. Cash
Mark A. Smith
Cyclooxygenase (COX)-2 and Clinical Progression of Alzheimer's Disease Dementia: Implications in the Role of Neuronal COX-2 in Cell Cycle	379	(14)
Giulio Maria Pasinetti
Parallels between the Redox Properties and Toxicity of Aβ in Alzheimer's Disease and Mutant Cu/Zn-SOD in Familial Amyotrophic Lateral Sclerosis	393	(14)
Ashley I. Bush
Β-Amyloid Toxicity: Diverse Biological Activities Drive Multiple Cellular Mechanisms	407	(14)
C. W. Cotman
L. Tong
A. Anderson
D. Cribbs
J. Su
Mechanisms of Aβ Production and Aβ Degradation: Routes to the Treatment of Alzheimer's Disease	421	(12)
D. J. Selkoe
W. Xia
W. T. Kimberly
K. Vekrellis
D. Walsh
W. P. Esler
M. S. Wolfe
A High Fat, High Cholesterol Diet Accelerates β-Amyloid Accumulation in the CNS of a Transgenic Mouse Model of Alzheimer's Disease	433	(16)
Lorenzo M. Refolo
Brian Malester
John LaFrancois
Tara Bryant-Thomas
Rong Wang
G. Stephen Tint
Kumar Sambamurti
Karen Duff
Miguel A. Pappolla
Electron Microscopy and X-ray Diffraction Studies further Confirm the Efficacy of PTI-00703TM® (Cat's Claw Derivative) as a Potential Inhibitor of Alzheimer's β-Amyloid Protein Fibrillogenesis	449	(12)
Gerardo M. Castillo
Daniel A. Kirschner
Ann G. Yee
Alan D. Snow
Accelerated Aβ Generation in a Cell Model of Alzheimer's Disease-related Endosomal-Lysosomal System Upregulation	461	(8)
Paul M. Mathews
Carolyn B. Guerra
Ying Jiang
Benjamin H. Kao
Ravi Dinakar
Pankaj Mehta
Anne M. Cataldo
Ralph A. Nixon
The Amyloid Precursor Protein V717I Mutation Increases Susceptibility to Cell Death in a Cholesterol-dependent Manner	469	(10)
Luigi Puglielli
Laura A. MacKenzie Ingano
Rudolph E. Tanzi
Dora M. Kovacs
Intracellular and Secreted Aβ42/40 Ratios Are Differently Influenced by APP Mutations	479	(8)
Heike S. Grimm
Stefan F. Lichtenthaler
Konrad Beyreuther
Tobias Hartmann
Familial British Dementia	487	(8)
Jorge Ghiso
Tamas Revesz
Agueda Rostagno
Ruben Vidal
Gordon Plant
Blas Frangione
Cellular Metabolism of Familial British Dementia-associated BRI-L	495	(12)
Seong-Hun Kim
Sangram S. Sisodia
A Decamer Duplication in the BRI Gene Originates a de novo Amyloid Peptide that Causes Dementia in a Danish Kindred	507	(8)
Ruben G. Vidal
Tamas Revesz
Agueda Rostagno
Toke Bek
Hans Braendgaard
Gordon Plant
Jorge Ghiso
Blas Frangione
Familial Alzheimer's Disease-linked Mutant Presenilins Attenuate Capacitative Calcium Entry	515	(6)
Isaac Cheng
Andrew S. Yoo
Rudolph E. Tanzi
Tae-Wan Kim
Presenilin-1 Is a Regulatory Component of the Cadherin Cell Adhesion Complex: Implications for Alzheimer's Disease	521	(10)
Anastasio Georgakopoulos
Philippe Marambaud
Nikolaos K. Robakis
Lia Baki
Presenilins and Notch Signaling Pathway	531	(10)
Weihong Song
Bruce A. Yankner
Functional Consequences of the Association of PS1 with β-Catenin	541	(8)
Salvador Soriano
David E. Kang
Nathalie Chevallier
Hui Zheng
Edward H. Koo
A Novel Protease Active Site Motif Conserved in Presenilins and Polytopic Bacterial Aspartyl Proteases?	549	(10)
Harald Steiner
Christian Haass
The Unfolded Protein Response-mediated Upregulation of BiP and CHOP Is not Affected by Presenilin Expression	559	(10)
Naoyuki Sato
Gopal Thinkaran
Mechanisms of α-Synuclein and NAC Fibrillogenesis	569	(18)
Makoto Hashimoto
Edward Rockenstein
Takato Takenouchi
Margaret Mallory
Eliezer Masliah
Neurofibrillary Degeneration: Patterns of Tau Isoform Expression	587	(14)
Andre Delacourte
Phosphorylation, Microtubule Binding and Aggregation of Tau Protein in Alzheimer's Disease	601	(8)
Jesus Avila
Jose J. Lucas
Filip Lim
Mar Perez
Felix Hernandez
Montserrat Arrasate
Rosario Armas Portela
Elsa Champion
George Perry
Mark A. Smith
Javier Diaz Nido
Phosphorylation of Protein Tau and Rescue of Protein Tau-induced Axonopathy by GSK-3β in GSK-3βxhtau40 Double Transgenic Mice	609	(12)
Kurt Spittaels
Chris Van den Haute
Jo Van Dorpe
Hugo Geerts
Fred Van Leuven
Pathogenic Implication of Altered Tau Properties Caused by FTDP-17 Mutations	621	(10)
P. Nacharaju
S. Yen
M. DeTure
C. Easson
M. Hutton
S.-H. Yen
A Hexapeptide Motif (306VQIVYK311)-forming β Structure Induces the Aggregation of Tau Protein to Paired Helical Filaments	631
M. von Bergen
J. Biernat
E.-M. Mandelkow
Eckhard Mandelkow
V. ANIMAL AND CELLULAR MODELS	341	(364)
Formation of Neurofibrillary Tangles in Mouse Brain	643	(8)
Akihiko Takashima
Kentaro Tanemura
Inducible Transgenic Expression of Wild-type tau in H4 Neuroglioma Cells	651	(10)
Michael De Ture
Li-Wen Ko
Colin Easson
Mike Hutton
Shu-Hui Yen
Lewy-like Pathology in Mice Transgenic for Mutant (A53T) and Wild-type Human α-Synuclein	661	(10)
Bernd Sommer
Samuel Barbieri
Katja Hofele
Karl-Heinz Wiederhold
Alphonse Probst
Claudia Mistl
Simone Danner
Sabine Kauffmann
Willibrordus Spooren
Markus Tolnay
Graeme Bilbe
Herman van der Putten
Somal and Neuritic Accumulation of the Parkinson's Disease-associated Mutant [A30P]α-Synuclein in Transgenic Mice	671	(8)
Phillipp J. Kahle
Manuela Neumann
Laurence Ozmen
Hans A. Kretzschmar
Christian Haass
Ex vivo Transmission of Mouse-adapted Prion Strains to N2a and GT1-7 Cell Lines	679	(8)
Sylvain Lehmann
Hubert Laude
David A. Harris
Richard I. Carp
Didier Vilette
Shigeru Katamine
Jean-Yves Madec
Noriyuki Nishida
In Vivo Perturbation of Lysosomal Function Promotes Neurodegeneration in the PS1M146V/APPK670N,M671L Mouse Model of Alzheimer's Disease Pathology	687	(10)
Ralph A. Nixon
Paul M. Mathews
Anne M. Cataldo
Panaiyur S. Mohan
Stephen D. Schmidt
Karen Duff
Martin Berg
Neville Marks
Corinne Peterhoff
Henry Sershen
Changes in Cognitive Characteristics of Tg(APP)CRND8 Mice at Early Stages of Immunization with Beta-Amyloid Peptide	697	(8)
Christopher Janus
Jacqueline Pearson
Patrick Horne
Richard Renlund
Karen Parisien
Azhar Chishti
Donna Heslin
Catherine Bergeron
Paul Fraser
Peter St George-Hyslop
David Westaway
VI. THERAPEUTICS AND THERAPEUTIC STRATEGIES	705	(116)
Galantamine, a Novel Treatment for Alzheimer's Disease: A Review of Long-term Benefits to Patients and Caregivers	707	(18)
Pierre Tariot
Bengt Winblad
Benefits of Donepezil on Cognition, Function and Neuropsychiatric Symptoms in Patients with Mild and Moderate Alzheimer's Disease over One Year	725	(14)
Gunhild Waldemar
Bengt Winblad
Knut Engedal
Hilkke Soininen
Frans Verhey
Anders Wimo
Anne-Lena Wetterholm
Richard Zhang
Anders Haglund
Ponni Subbiah
Characterization of Alzheimer's β-Secretase Protein BACE: Processing and Other Post-translational Modifications	739	(1)
Mitsuru Haniu
Brian D. Bennett
Paul Denis
Yunjen Young
Elizabeth A. Mendiaz
Janis Fuller
John O. Hui
Steven Kahn
Safura Babu-Khan
Sandra Ross
Teresa Burgess
Viswanatham Katta
Margery Nicolson
Jonathan Lull
Shue-Yuan Wang
Gary Rogers
Robert Vassar
Martin Citron
Androgen Treatment Reduces Cognitive Deficits in Female apoE4 Transgenic Mice	739	(8)
Jacob Raber
Anthony LeFevour
Lennart Mucke
Studies with the Memory-enhancing Drug AIT-082 in PC12 Cells	747	(12)
Debomoy K. Lahiri
Yuan-Wen Ge
Martin R. Farlow
Generation of Auto-antibodies toward Alzheimer's Disease Vaccination	759	(18)
Beka Solomon
Dan Frenkel
Toward the Identification of γ-Secretase: Using Transition State Analog Inhibitors	777	(12)
William P. Esler
W. Taylor Kimberly
Beth L. Ostaszewski
Weiming Xia
Dennis J. Selkoe
Michael S. Wolfe
Photoactivated, Active-site-directed γ-Secretase Inhibitors Covalently Label Presenilin 1	789	(10)
Stephen J. Gardell
Yue-Ming Li
Min Xu
Ming-Tain Lai
Qian Huang
Jose L. Castro
Jillian DiMuzio-Mower
Timothy Harrison
Colin Lellis
Alan Nadin
Joseph G. Neduvelil
R. Bruce Register
Mohinder K. Sardana
Mark S. Shearman
Xiao-Ping Shi
Adrian L. Smith
Kuo-Chang Yin
Jules A. Shafer
Functional Analysis of β-Secretase Using Mutagenesis and Structural Homology Modeling	799	(10)
Gwen Tatsuno
John Anderson
Jin Hong
David A. Agard
Nobuyuki Ota
Sukanto Sinha
Guriqbal Basi
Lisa McConlogue
Therapeutic Approaches to Prion Diseases: In Vitro Studies with Tetracycline Compounds	809	(12)
Tazeen Awan
Gianluigi Forloni
Enzio Ragg
Selina Iussich
Giacomina Rossi
Laura Colombo
Laura Girola
Tania Massignan
Orso Bugiani
Mario Salmona
Fabrizio Tagliavini
VII. PSYCHOSOCIAL CARE	821	(14)
Influence of a Memory Training Program on Attention and Memory Performance of Patients with Dementia	823	(10)
Tanja Bernhardt
Konrad Maurer
Lutz Frolich
Prediction of Use of Emergency Community Services by Cognitively Impaired Seniors who Live Alone: Preliminary Findings of a Prospective Study	833	(2)
Mary C. Tierney
Jocelyn Charles
W. Gary Snow
John P. Szalai
Susan Jaglal
Franca Spizzirri
Rory H. Fisher
Index	835