Written by leaders in the field, Analytical Methods in Combinatorial Chemistry is the first comprehensive review of analytical methods in this field, with a focus on combinatorial drug discovery. The second edition updates the first with close to 50% new material and a detailed discussion of new developments in analytical methods, technologies, and applications in combinatorial chemistry in the past three years. The book also includes new chapters on high-throughput purification and the application of combinatorial chemistry in materials science and catalyst discovery. It focuses on new drug candidates and drugs developed through combinatorial chemistry.

Analytical issues in combinatorial chemistry
Combinatorial chemistry
Synthesis methods
Analytical challenges
Properties of solid supports
Reaction Optimization Stage
Library synthesis stage
Lead selection and optimization stage
An examination of the analytical sample: resin support
Physical properties of resins
Resin type
Resin bead size distribution
Loading and the intraresin site distribution
Thermal stability
Chemical stabilityResin swelling and solvation
Effects of swelling on resin
Effects of swelling on reagent and solvent molecules
Swelling ability of solvents
Dynamic resin solvationEffects of the solvated resin on solid-phase reactions
The effects of support solvation on SPPS
Resin support as another "solvent phase"
Support effects on SPOS reaction kinetics
Site separation and site interaction
Solid support effects on product purity
Solid-phase reaction optimization using FTIR
Comparison of FTIR and Raman techniques
Techniques
Analysis of resin-bound compounds
Comparison of techniques
Monitoring of polymer-supported organic reactionsThe monitoring of reactions on polystyrene-based resin
Yes-and-no information
Reaction kinetics on resin support
Quantitative estimation of chemical conversions (%) on resin
The selection of optimal reaction conditions using single-bead IRThe monitoring of reactions on PS-PEG resins: comparing the reaction rate on PS and PS-PEG resins
Background
Examples
Examples: Peptide secondary structure on resin supportThe monitoring of reactions on surface-functionalized polymers
Techniques
ExamplesParallel reaction monitoring
Reaction optimization using MS and NMR methods
MS methods
NMR methods
Gel-phase NMR
Magic angle spinning (MAS) NMR
Other NMR methods
Reaction optimization using spectrophotometric and other methods
Qualitative analysis of amines
Quantitative analysis of amines
Quantitative spectroscopic methods for organic functional groups
Quantitation of aldehyde/ketone groups
Quantitation of hydroxyl groups on resin
Quantitation of carboxyl groups on resin
Quantitation of polymer-supported sulfhydryl groupsCombustion elemental analysis methods
Analysis of resin-bound organic compounds
Quantitatively monitoring SPOS reactionsElectrochemical methods
On-resin X-ray, EPR, SERS, and fluorescence methods
Quality control of combinatorial libraries
Analysis of discrete compound libraries
MS analysis
MS-guided purification
High-throughput NMR
Analysis of pooled libraries
Theoretical calculation of mass distribution
MS analysis
High-resolution MS
Tandem MS
Liquid chromatography (LC)/MS and capillary electrophoresis (CE)/MS
NMR methods for mixture analysisHPLC for analyzing compounds from discrete and mixture libraries
HPLC with a chemiluminescence nitrogen detector (CLND)
Evaporative light scattering detector (ELSD)
High-throughput purification
Nonchromatographic high-throughput purification methods
Chromatographic high-throughput purification methods
Supercritical fluid chromatographic purification methods
Purification methods based on fluorous chemistry separation technique
Fluorous liquid-liquid extraction (F-LLE)
Fluorous solid-phase extraction (F-SPE)
Fluorous HPLC (F-HPLC)
Fluorous-flash chromatography (F-FC)
Final Thoughts and Future Perspectives
Stability of compound collections
Nano-combinatorial library and associated analytical issues
Green process and technologies
Table of Contents provided by Publisher. All Rights Reserved.

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.