Animal Models of Acute Neurological Injuries

by Chen, Jun; Xu, Xiao-ming; Zhang, John H.

• ISBN13: 9781603271844
• ISBN10: 1603271848
• Format: Hardcover
• Copyright: 2008-10-22
• Publisher: Humana Pr Inc

Summary

Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires. Book jacket.

Table of Contents

Animal Care and Surgery
Animal Protocol	p. 3
Anesthesia and Analgesia for Research Animals	p. 11
Rodent Surgical Procedures and Tissue Collection	p. 19
Brain Monitoring	p. 39
Veterinary Care Methods for Rats and Mice in Experimental Spinal Cord Injury Studies	p. 47
Cerebral Ischemic Animal Models
Global Cerebral Ischemic Models
Four-Vessel Occlusion Model in Rats	p. 65
Rat Model of Global Cerebral Ischemia: The Two-Vessel Occlusion (2VO) Model of Forebrain Ischemia	p. 77
Asphyxial Cardiac Arrest	p. 87
Rodent Model of Pediatric Asphyxial Cardiac Arrest	p. 103
Transient Global Cerebral Ischemia Model in Mice	p. 115
Focal Cerebral Ischemic Models
Transient Middle Cerebral Artery Occlusion Model in Rodents	p. 129
Three-Vessel Middle Cerebral Artery Occlusion Model	p. 141
A Thromboembolic Rat Model of Focal Cerebral Ischemia and Reperfusion with tPA	p. 155
Targeted Occlusion to Surface and Deep Vessels in Neocortex via Linear and Nonlinear Optical Absorption	p. 169
Middle Cerebral Artery Occlusion Suture Model for Mice	p. 187
Intraluminal Middle Cerebral Artery Occlusion Model in Mice	p. 197
Cerebral Hypoxia-Ischemia Model in Adult Mice	p. 207
Neonatal Hypoxia-Ischemia
Cerebral Hypoxia-Ischemia in Neonatal Rats or Mice: A Model of Perinatal Brain Injury	p. 221
Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits	p. 231
Model of Neonatal Focal Cerebral Ischemia-Reperfusion	p. 247
Cerebral Hemorrhage Animal Models
Subarachnoid Hemorrhage
Monofilament Perforation Subarachnoid Hemorrhage Rat Model	p. 261
Blood Injection Subarachnoid Hemorrhage Rat Model	p. 271
Filament Perforation Subarachnoid Hemorrhage: Mouse Model	p. 279
Blood Injection Subarachnoid Hemorrhage Mouse Model	p. 287
Cerebral Vasospasm
Blood Injection Cerebral Vasospasm Rabbit Model	p. 295
Double Blood-Injection Cerebral Vasospasm Canine Model	p. 301
Nonhuman Primate Blood-Clot Placement Cerebral Vasospasm Model	p. 315
Intracerebral Hemorrhage
Blood Injection Intracerebral Hemorrhage Rat Model	p. 331
Bacterial Collagenase Injection Intracerebral Hemorrhage Rat Model	p. 337
Blood Injection Intracerebral Hemorrhage Mouse Model	p. 349
Blood Injection Intracerebral Hemorrhage Pig Model	p. 359
Traumatic CNS Injury Animal Models
Experimental Brain Injury Models
Fluid Percussion Injury Model	p. 369
Controlled Cortical Impact Injury Model	p. 385
Marmarou Weight Drop Injury Model	p. 393
Experimental Spinal Cord Injury Models
MASCIS Spinal Cord Contusion Model	p. 411
Infinite Horizon Spinal Cord Contusion Model	p. 423
The Ohio State University ESCID Spinal Cord Contusion Model	p. 433
Acute Clip Impact-Compression Model	p. 449
Experimental Laceration Spinal Cord Injury Model	p. 461
Rodent Spinal Cord Demyelination Models	p. 471
Spinal Cord Lateral Hemisection and Implantation of Guidance Channels	p. 479
Spinal Root Avulsion and Repair Model	p. 487
Index	p. 497
Table of Contents provided by Ingram. All Rights Reserved.