Animal Models of Dementia

by De Deyn, Peter Paul; Van Dam, Debby

• ISBN13: 9781607618973
• ISBN10: 1607618974
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-12-30
• Publisher: Humana Pr Inc

Summary

With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that stress the importance of extensively validated animal models in drug discovery and development in order to predict clinical activity. Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer's disease, Parkinson's disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models.Comprehensive and efficient, Animal Models of Dementia will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research.

Table of Contents

Series Preface	p. v
Preface	p. vii
Contributors	p. xiii
Animal Modeling: General and Ethical Aspects and Drug Discovery Pipeline
General Introduction to Animal Models of Human Conditions	p. 3
Animal Models of Dementia: Ethical Considerations	p. 15
The Role of Rodent Models in the Drug Discovery Pipeline for Dementia	p. 35
Methodological Considerations when Developing Animal Models of Dementia
Species, Strain, and Gender Issues in the Development and Validation of Animal Models of Dementia	p. 53
Transgenic and Gene Targeted Models of Dementia	p. 77
Transgenic Animals and Intellectual Property Concerns	p. 91
Validation of Animal Models of Dementia
Pathological Validation of Animal Models of Dementia	p. 99
Behavioral Validation in Animal Models of Dementia	p. 143
Pharmacological Validation in Animal Models of Dementia	p. 155
Validation of Animal Models of Dementia: Neurochemical Aspects	p. 169
Validation of Dementia Models Employing Neuroimaging Techniques	p. 187
Animal Models of Alzheimer's Disease
Drosophila Melanogaster as a Model Organism for Dementia	p. 223
Caenorhabditis elegans as a Model Organism for Dementia	p. 241
Zebrafish (Danio rerio) as a Model Organism for Dementia	p. 255
Spontaneous Vertebrate Models of Alzheimer Dementia: Selectively Bred Strains (SAM Strains)	p. 271
Lesion-Induced Vertebrate Models of Alzheimer Dementia	p. 295
Aß Infusion and Related Models of Alzheimer Dementia	p. 347
APP-Based Transgenic Models: The PDAPP Model	p. 371
APP-Based Transgenic Models: The Tg2576 Model	p. 387
APP-Based Transgenic Models: The APP23 Model	p. 399
Presenilin-Based Transgenic Models of Alzheimer's Dementia	p. 415
APOE-Based Models of "Pre-Dementia"	p. 439
TAU Models	p. 449
The 3xTg-AD Mouse Model: Reproducing and Modulating Plaque and Tangle Pathology	p. 469
Animal Models of Non-Alzheimer Neurodegenerative Disease
Cognitive Dysfunction in Genetic Mouse Models of Parkinsonism	p. 485
Mouse Models of Metachromatic Leukodystrophy and Adrenoleukodystrophy	p. 493
Animal Models of Amyotrophic Lateral Sclerosis	p. 515
Animal Models of Frontotemporal Dementia	p. 533
Animal Models of Vascular Dementia
CADASIL: Molecular Mechanisms and Animal Models	p. 551
Spontaneously Hypertensive Rat (SHR): An Animal Model of Vascular Brain Disorder	p. 577
Animal Models of Normal Pressure Hydrocephalus
Animals Models of Normal Pressure Hydrocephalus	p. 615
Animal Models of Traumatic Dementia
Animal Models of Traumatically-Induced Dementia	p. 643
Animal Models of Toxic Dementia
Animal Models of Alcohol-Induced Dementia	p. 665
Animal Models of Metallic Dementia	p. 685
Index	p. 727
Table of Contents provided by Ingram. All Rights Reserved.