Animal Models-Disorders of Eating Behaviour and Body Composition

by Owen, John B.; Treasure, Janet; Collier, David A.

• ISBN13: 9780792370956
• ISBN10: 0792370953
• Format: Hardcover
• Copyright: 2001-11-01
• Publisher: Kluwer Academic Pub

Summary

This book deals with a novel aspect of a topical problem that is of widespread concern. Obesity and other eating disorders are significant human health problems that are proving highly resistant to prevention and cure. The recognition of important genotype/environment interaction in the causation of these problems and of the extensive genetic homology of higher animals justifies the importance of cross-species comparisons. The book covers observations made on animals in the wild as well as experimental data on laboratory animals and farm animals in order to lay out the basic genetic and environmental factors underlying the control of appetite (including diet selection) and body weight. Breakdown in these intricate mechanisms are then compared to examine the possible common candidate genes and their interaction with non-genetic factors, particularly the availability of diet choice and of levels of body activity. Animals have much to tell us about these mysteries and may significantly aid progress in dealing with what are still highly intractable and serious diseases of the modern world.

Table of Contents

Introduction	vii
Part 1 Human disorders of eating behavior and body composition
Obesity syndromes	1	(18)
M. S Bray
D B Allison
The spectrum of eating disorders in humans	19	(32)
J L Treasure
D A Collier
Free-choice diet selection - the economics of eating	51	(18)
C V Phillips
Part 2 Diet selection and aberrations of body composition
Diet selection in wild animals	69	(14)
L Hansson
The animal within: lessons from the feeding behaviour of farm animals	83	(14)
Kyriazakis
Exercise and diet-induced obesity in mice	97	(22)
R R Bell
Part 3 Genetic models of animal obesity
The obesity (ob) gene and leptin in animal models of obesity	119	(14)
K A Augustine-Rauch
Genetic susceptibility of rodents to diet-induced obesity	133	(26)
J Harrold
Part 4 Genetic susceptibility to leanness in animals
Muscle enhanced traits in cattle and sheep	159	(14)
N E Cockett
C A Bidwell
The halothane gene and leanness and stress susceptibility in pigs	173	(20)
P Kathirvel
A L Archibald
Part 5 Anorexia models
The Anorexia Mouse	193	(12)
J Johansen
M Schalling
Anorexia-like wasting syndromes in pigs	205	(18)
S C Kyriakis
Laboratory animal models for investigating the mechanisms and function of parasite-induced anorexia	223	(20)
J G Mercer
L H Chappell
Conclusion Implications for understanding and treating human eating disorders	243	(4)
Editorial
Index	247