Annual Review of Pharmacology and Toxicology

by Cho, Arthur K.

• ISBN13: 9780824304409
• ISBN10: 0824304403
• Format: Hardcover
• Copyright: 2000-10-01
• Publisher: Annual Reviews

Table of Contents

Targets of Drug Action;	1	(18)
A.S.V. Burgen
Laboratory of Chemical Pharmacology, National Heart, Lung, and Blood Institute, NIH: A Short History	19	(24)
James R. Gillette
Chlorinated Methanes and Liver Injury: Highlights of the Past 50 Years	43	(24)
Gabriel L. Plaa
Pharmacokinetic/Pharmacodynamic Modeling in Drug Development	67	(30)
L. B. Sheiner
J-L. Steimer
Sequencing the Entire Genomes of Free-Living Organisms: The Foundation of Pharmacology in the New Millenium	97	(36)
Samuel Broder
J. Craig Venter
High-Throughput Screening in Drug Metabolism and Pharmacokinetic Support of Drug Discovery	133	(26)
Ronald E. White
Pharmacogenetics of Sulfotransferase	159	(18)
K. Nagata
Y. Yamazoe
Drug Discovery in the Next Millennium	177	(16)
Eliot H. Ohlstein
Robert R. Ruffolo Jr.
John D. Elliott
The Impact of Genomics on Drug Discovery	193	(16)
C. Debouck
B. Metcalf
Simulation of Clinical Trials	209	(26)
N. H. G. Holford
H. C. Kimko
J. P. R. Monteleone
Carl C. Peck
The Regulator of G Protein Signaling Family	235	(38)
Luc De Vries
Bin Zheng
Thierry Fischer
Eric Elenko
Marilyn G. Farquhar
Parallel Array and Mixture-Based Synthetic Combinatorial Chemistry: Tools for the Next Millennium	273	(10)
Richard A. Houghten
Pharmacology of Selectin Inhibitors in Ischemia/Reperfusion States	283	(12)
David J. Lefer
A Novel Means of Drug Delivery: Myoblast-Mediated Gene Therapy and Regulatable Retroviral Vectors	295	(24)
Clare R. Ozawa
Matthew L. Springer
Helen M. Blau
5-HT6 Receptors as Emerging Targets for Drug Discovery	319	(16)
Theresa A. Branchek
Thomas P. Blackburn
The Impact of Genomics-Based Technologies on Drug Safety Evaluation	335	(18)
Jeffrey F. Waring
Roger G. Ulrich
Mitochondrial Targets of Drug Toxicity	353	(36)
K. B. Wallace
A. A. Starkov
Molecular Mechanisms and Regulation of Opiod Receptor Signaling	389	(42)
Ping-Yee Law
Yung H. Wong
Horace H. Loh
Nicotinic Receptors at the Amino Acid Level	431	(28)
Pierre-Jean Corringer
Nicolas Le Novere
Jean-Pierre Changeux
The Role of Rho in G Protein Coupled Receptor Signal Transduction	459	(32)
Valerie P. Sah
Tammy M. Seasholtz
Sarah A. Sagi
Joan Heller Brown
Central Role of Peroxisome Proliferator-Activated Receptors in the Actions of Peroxisome Proliferators	491	(28)
J. Christopher Corton
Steven P. Anderson
Anja Stauber
The PAS Superfamily: Sensors of Environmental and Developmental Signals	519	(44)
Yi-Zhong Gu
John B. Hogenesch
Christopher A. Bradfield
Pharmacology of Cloned P2X Receptors	563	(18)
R. Alan North
Annmarie Surprenant
Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease	581	(36)
Robert H. Tukey
Christian P. Strassburg
14--3--3 Proteins: Structure, Function, and Regulations	617	(32)
Haian Fu
Romesh R. Subramanian
Shane C. Masters
Dual Protease Inhibitor Therapy in HIV-Infected Patients: Pharmacologic Rationale and Clinical Benefits	649
Charles Flexner
Indexes
Subject Index	675
Cumulative Index of Contributing Authors, Volumes 36--40	687
Cumulative Index of Chapter Titles, Volumes 36--40	690