Karl Drlica, Ph.D. is a Principal Investigator at the Public Health Research Institute and Professor of Microbiology & Molecular Genetics at the UMDNJ–New Jersey Medical School in Newark. His laboratory focuses on fluoroquinolone action and resistance with Mycobacteriun tuberculosis and other bacteria, including approaches for slowing the enrichment and amplification of resistant bacterial subpopulations.
David S. Perlin, Ph.D. is Executive Director of the Public Health Research Institute and UMDNJ Regional Biocontainment Laboratory, as well as Professor of Microbiology & Molecular Genetics at the New Jersey Medical School in Newark. He is also a Fellow of the New York Academy of Sciences. Dr. Perlin’s laboratory explores mechanisms of antifungal drug-resistance, rapid detection of drug resistant bloodstream pathogens in high-risk patients, and the application of small-animal models for the study of respiratory pathogens.
Preface xv
Chapter 1 Introduction to the Resistance Problem 1
Chapter 2 Working with Pathogens 17
Chapter 3 A Survey of Antibiotics 31
Chapter 4 Dosing to Cure 55
Chapter 5 Emergence of Resistance 73
Chapter 6 Movement of Resistance Genes Among Pathogens 91
Chapter 7 Transmission of Resistant Disease 105
Chapter 8 Surveillance 125
Chapter 9 Making New Antibiotics 139
Chapter 10 Restricting Antibiotic Use and Optimizing Dosing 149
Chapter 11 Influenza and Antibiotic Resistance 167
Chapter 12 Avoiding Resistant Pathogens 177
Afterword A Course of Action 203
Appendix A Molecules of Life 207
Appendix B Microbial Life Forms 221
Glossary 227
Literature Cited 233
Index 251
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