Anticancer Drug Toxicity

Summary

Containing the latest findings on the toxicity of a wide range of chemotherapeutic agents, this up-to-the-minute reference offers expert analyses on the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity explores therapeutic drug monitoring (TDM) as a method of maximizing the efficacy, and minimizing the dangers, of chemotherapy presents a vast amount of clinical pharmacokinetic data on cytostatic drugs offers a comprehensive classification of toxicity patterns associated with the use of cytotoxic drugs analyzes the pharmacokinetics of alkylating agents, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and other cytotoxic agents highlights the pharmacogenetics of 6-mercaptopurine and its clinical significance explicates toxicity in relation to the lungs, kidneys, heart, and gonads examines disorders caused by asparaginase preparations reviews types of secondary malignancy such as leukemias, ovarian cancer, testicular cancer, breast cancer, secondary solid neoplasias, and Hodgkin's disease clarifies the understanding of toxicity as a crucial element in supportive management of cancer therapy and more! An enormously practical guide for everyday clinical practice, as well as a source of inspiration for further research in the field, Anticancer Drug Toxicity is an invaluable reference for clinical and medical oncologists; hospital, industrial, and clinical pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and medical school students in these disciplines.

Preface

iii

Contributors

vii

PART I INTRODUCTION AND CLINICAL PHARMACOKINETICS

Introduction

(8)

Hans-Peter Lipp

Clinical Pharmacokinetics of Cytostatic Drugs: Efficacy and Toxicity

(194)

Hans-Peter Lipp

Carsten Bokemeyer

PART II TOXICITY OF CYTOSTATICS IN RAPIDLY PROLIFERATING NORMAL CELLS

Prophylaxis and Treatment of Neutropenia with Hematopoietic Growth Factors

205

(30)

Hartmut Link

Oral and Gastrointestinal Toxicity

235

(28)

Carsten Bokemeyer

J.T. Hartmann

Dermatological Toxicity and Hypersensitivity Reactions Associated with the Use of Cytostatics

263

(16)

Hans-Peter Lipp

PART III EXTRAVASATION AND PARAVASATION

Managing Extravasations of Vesicant Chemotherapy Drugs

279

(42)

Robert T. Dorr

PART IV ORGAN TOXICITY INDUCED BY CYTOSTATIC AGENTS

Nephrotoxicity and Urotoxicity of Chemotherapeutic Agents

321

(26)

Roderick Skinner

Hepatotoxicity Induced by Cytostatic Drugs

347

(84)

Hans-Peter Lipp

Joachim Boos

Eugen J. Verspohl

Eugene Y. Krynetski

William E. Evans

Neurotoxicity (Including Sensory Toxicity) Induced by Cytostatics

431

(24)

Hans-Peter Lipp

Pulmonary Toxicity of Chemotherapeutic Agents

455

(16)

Jost Niedermeyer

H. Fabel

Carsten Bokemeyer

Hans-Peter Lipp

Cardiotoxicity of Cytotoxic Drugs

471

(20)

Hans-Peter Lipp

PART V LATE SIDE EFFECTS OF CANCER CHEMOTHERAPY

Gonadal Toxicity and Teratogenicity After Cytotoxic Chemotherapy

491

(34)

Elizabeth B. Lamont

Robert L. Schilsky

Secondary Malignancies

525

(24)

Carsten Bokemeyer

Christian Kollmannsberger

Index

549

Supplemental Materials

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