Antimicrobial Chemotherapy

by Greenwood, David

• ISBN13: 9780192631954
• ISBN10: 0192631950
• Edition: 4th
• Format: Paperback
• Copyright: 2000-09-14
• Publisher: Oxford University Press

Summary

The essence of this book is to describe the basic properties ofantibiotics and other antimicrobial agents and to discuss the principlesunderlying the rational use of antimicrobial agents in the management ofinfection. The aim is to encourage good prescribing habits in doctors throughoutthe world. After a short historical introduction, the text deals with thegeneral properties of antimicrobial compounds of all kinds (antibacterial,antiviral, antifungal, antiprotozoal and antielminthic agents); laboratoryaspects of antimicrobial chemotherapy (including antibiotic interactions and useof the laboratory);resitance to antimicrobial agents (including mechanismsn ofresistance and the control of resistance);general principles of antibiotic usage(including pharmacokinetic issues, the prophylactic use of antibiotics, andspecial concerns of treatment of young children and the elderly) and the use ofantimicrobial therapy in specific types of infection. There is a postcript onthe development and marketing of antimicrobial agents.Reviews of previous editions: 'This reasonably priced volume is recommendedwithout reservation for students and junior doctors, pharmacists, laboratory andother health care staff. I would also recommend it for microbiologydepartmental libraries.' Journal of Infection'...... well written, accomplishing the stated aims. All tables are essentialto the discussion and easy to understand. American Journal of PharmaceuticalEducation'The new edition retains the formula-winning layout of the first edition ... Itis, to my knowledge, the only authoritative book written at this level, and itis required reading for students. Journal of Hospital Infection'The book covers an enormous amount of material, dealing as it does withantibacterial, antifungal, antiprotozoan and antiviral agents. Almost everyaspect is covered ... the authors have in general managed to distil into thetext the essential elements of the topics and ensure that the treatment is notsuperficial ... this paperback edition ... is very good value for money. It cantruly be considered to cover, at a basic level, "all you need to know" aboutantimicrobial chemotherapy and can be highly recommended for junior clinicalstaff, pharmacy staff and junior biomedical scientists; their more seniorcolleagues will also find much of value in this new edition of AntimicrobialChemotherapy.' British Journal of Biomedical Science'This updated textbook provides young doctors and students with thefundamental principles of antimicrobial chemotherapy. This third edition hasbeen thoroughly revised and extensively rewritten. Drugs of Today'...excellently suited for trainee nurses, pharmacists and medical laboratoryscience officers ... Its short, but comprehensive covering of the topic make ithighly advisable for everyone looking for basic knowledge of the properties anduses of antimicrobial drugs.' Infection'I think this is a useful reference textbook which undergraduate medicalstudents will find beneficial in coming to grips with the principles ofantimicrobial chemotherapy.' Journal of Medical Microbiology

Table of Contents

List of contributors	xiii
Historical introduction	1	(8)
D. Greenwood
PART I: GENERAL PROPERTIES OF ANTIMICROBIAL AGENTS	9	(90)
Inhibitors of bacterial cell wall synthesis	11	(18)
D. Greenwood
Inhibitors of bacterial protein synthesis	29	(17)
D. Greenwood
Synthetic antibacterial agents and miscellaneous antibiotics	46	(13)
D. Greenwood
Antifungal agents	59	(7)
D. Greenwood
Antiprotozoal and anthelminthic agents	66	(11)
D. Greenwood
Antiviral agents	77	(16)
W. L. Irving
Antiretroviral agents	93	(6)
W. L. Irving
PART II: LABORATORY ASPECTS OF ANTIMICROBIAL THERAPY	99	(36)
Antibiotic sensitivity testing and assay	101	(17)
D. Greenwood
R. C. B. Slack
Antibiotic interactions	118	(8)
D. Greenwood
Use of the laboratory	126	(9)
R. C. B. Slack
PART III: RESISTANCE TO ANTIMICROBIAL AGENTS	135	(38)
The problem of resistance	137	(8)
K. J. Towner
Mechanisms of acquired resistance	145	(11)
K. J. Towner
The genetics of resistance	156	(8)
K. J. Towner
Control of the spread of resistance	164	(9)
A. M. Emmerson
PART IV: GENERAL PRINCIPLES OF USAGE OF ANTIMICROBIAL AGENTS	173	(50)
General principles of the treatment of infection	175	(8)
R. G. Finch
Pharmacokinetics	183	(10)
D. Greenwood
Prescribing for children and the elderly	193	(7)
R. G. Finch
Adverse reactions to antibiotics	200	(12)
R. G. Finch
Chemoprophylaxis	212	(11)
R. C. B. Slack
PART V: THE THERAPEUTIC USE OF ANTIMICROBIAL AGENTS	223	(164)
Respiratory tract infections	225	(10)
A. M. Emmerson
Urinary infections	235	(7)
R. C. B. Slack
Gastrointestinal infections	242	(11)
R. G. Finch
Bacteraemia and endocarditis	253	(19)
R. G. Finch
Skin and soft-tissue infections	272	(8)
P. J. Wilkinson
Bone and joint infections	280	(7)
P. J. Wilkinson
Mycobacterial disease	287	(14)
A. M. Emmerson
Meningitis and brain abscess	301	(17)
R. G. Finch
Viral infections	318	(17)
W. L. Irving
Infection in immunocompromised patients	335	(10)
R. G. Finch
Sexually transmitted infections	345	(9)
R. C. B. Slack
Parasitic diseases	354	(14)
R. C. B. Slack
Topical use of antimicrobial agents	368	(8)
R. C. B. Slack
Postscript: The development and marketing of antimicrobial drugs	376	(11)
D. Greenwood
Recommendations for further reading	387	(4)
Index	391