Antimicrobial Resistance and Implications for the Twenty-First Century

by Fong, I. W.; Drlica, Karl

• ISBN13: 9780387724171
• ISBN10: 0387724176
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-10-09
• Publisher: Springer Nature

Summary

Antimicrobial resistance can develop in any type of microbe (germ). Microbes can develop resistance to specific medicines. A common misconception is that a person's body becomes resistant to specific drugs. However, it is microbes, not people that become resistant to the drugs. Drug resistance happens when microbes develop ways to survive the use of medicines meant to kill or weaken them. If a microbe is resistant to many drugs, treating the infections it causes can become difficult or even impossible. Someone with an infection that is resistant to a certain medicine can pass that resistant infection to another person. In this way, a hard-to-treat illness can be spread from person to person. In some cases, the illness can lead to serious disability or even death. This comprehensive, up-to-date volume aims to define issues and potential solutions to the challenges of antimicrobial resistance. The chapter authors are leading international experts on antimicrobial resistance among a variety of bacteria (Streptococcus pneumoniae, enteroccoci, staphylococci, gram-negative bacilli, mycobacteria species) viruses (HIV, herpesviruses), parasites (malaria, leishmaniasis) and fungi (Candida species, fusarium etc.). The chapters will explore the molecular mechanisms of drug resistance, the immunology and epidemiology of resistance strains, clinical implications and implications on research and lack thereof, and prevention and future directions. This volume will also describe the steps that researchers are taking to develop molecular methods for detecting resistance; develop drugs and other means to deal with newly-resistant organisms. A special chapter to address the issues on strategies to limit antimicrobial resistance propagation will be included in this volume.

Table of Contents

Preface

Mechanisms of Resistance by Gram Positive Bacteria (Streptococci and Enterococci)

Emergence of MRSA in the Community

Antimicrobial Resistance to Sexually Transmitted Infections

Resistance of Gram Negative Bacilli to Antimicrobials

Mycobacterial Antimicrobial Resistance

Antimicrobial Resistance of Anaerobic Bacteria

Clinical Significance and Biological Basis of HIV Drug Resistance

Resistance of Herpesviruses to Antiviral Agents

Hepatitis Virus Resistance

Resistance to Antifungal Agents

An Anti-Mutant Approach for Antimicrobial Use

Index

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