Antioxidants in Diabetes Management

by Rosen; Peter

• ISBN13: 9780824788445
• ISBN10: 0824788443
• Format: Hardcover
• Copyright: 2000-02-18
• Publisher: CRC Press

Summary

This volume summarizes current understanding of the pathogenic role of oxidative stress in the onset and progression of diabetes and its complications, and presents results of studies aimed at regulating oxidatively induced complications through the use of antioxidants. Examines the presence of impaired microcirculation, capillary hypoxia, and ischemia syndrome in diabetic complications! Designed to stimulate scientific discussion and curiosity about the causes of diabetes, with contributions from nearly 65 clinicians and researchers who cite more than 1300 sources, Antioxidants in Diabetes Management focuses on stringent control of hyperglycemia to prevent or modify onset and progression promotes the development of intervention strategies because of the therapeutic limitations of hypoglycemic therapy emphasizes the potential synergistic effects of an interlinked antioxidant network investigates the controversy surrounding the significance of oxidative stress markers in diabetes highlights oxidative stress and antioxidant treatment in animal models for juvenile and adult onset diabetes explores the hypothesis that ischemic reperfusion is the primary cause of diabetic polyneuropathy links protein kinase C activation to the development of diabetic vascular complications and the effectiveness of vitamin E in preventing these abnormalities spotlights recent clinical trials of therapeutic effects of antioxidants to reduce insulin resistance and much more! Illustrating the therapeutic potential of antioxidants for the treatment of diabetes, Antioxidants in Diabetes Management is an unparalleled reference for endocrinologists, nutritionists and dietitians, cell biologists and biochemists, cardiologists, pathologists, and graduate and medical school students in these disciplines.

Table of Contents

Series Introduction	iii
Lester Packer
Enrique Cadenas
Preface	vii
Contributors	xvii
Oxidative Stress and Antioxidants: The Antioxidant Network, α-Lipoic Acid, and Diabetes	1	(16)
Lester Packer
Oxidative Stress in Diabetes: Why Does Hyperglycemia Induce the Formation of Reactive Oxygen Species?	17	(16)
Peter Rosen
Xueliang Du
Guang-Zhi Sui
Oxidative Stress Markers in Human Disease: Application to Diabetes and to Evaluation of the Effects of Antioxidants	33	(20)
Barry Halliwell
Plasma Lipid Hydroperoxide and Vitamin E Profiles in Patients with Diabetes Mellitus	53	(12)
Jaffar Nourooz-Zadeh
Concentrations of Antioxidative Vitamins in Plasma and Low-Density Lipoprotein of Diabetic Patients	65	(12)
Wolfgang Leonhardt
Oxidative Stress in Diabetes	77	(16)
John W. Baynes
Suzanne R. Thorpe
Antioxidative Defense in Diabetic Peripheral Nerve: Effects of DL-α-Lipoic Acid, Aldose Reductase Inhibitor, and Sorbitol Dehydrogenase Inhibitor	93	(18)
Irina G. Obrosova
Douglas A. Greene
Hans-Jochen Lang
Pathways of Glucose-Mediated Oxidative Stress in Diabetic Neuropathy	111	(10)
Douglas A. Greene
Irina G. Obrosova
Martin J. Stevens
Eva L. Feldman
Experimental Diabetic Neuropathy: Oxidative Stress and Antioxidant Therapy	121	(8)
Hans J. Tritschler
James D. Schmelzer
Yutaka Kishi
Yoshiyuki Mitsui
Masaaki Nagamatsu
Kim K. Nickander
Paula J. Zollman
Phillip A. Low
Antioxidants in the Treatment of Diabetic Polyneuropathy: Synergy with Essential Fatty Acids	129	(26)
Norman E. Cameron
Mary A. Cotter
A Thioctic Acid--Gamma-Linolenic Acid Conjugate Protects Neurotrophic Support in Experimental Diabetic Neuropathy	155	(18)
Luke Hounsom
David R. Tomlinson
Clinical Trials of α-Lipoic Acid in Diabetic Polyneuropathy and Cardiac Autonomic Neuropathy	173	(12)
Dan Ziegler
Oxidative Stress, NF-&kappaB Activation, and Late Diabetic Complications	185	(20)
Peter P. Nawroth
Valentin Borcea
Angelika Bierhaus
Martina Joswig
Stephan Schiekofer
Hans J. Tritschler
Role of Oxidative Stress and Antioxidants on Adhesion Molecules and Diabetic Microangiopathy	205	(14)
Klaus Kusterer
Jorg Bojunga
Gerald Bayer
Thomas Konrad
Eva Haak
Thomas Haak
Klaus H. Usadel
Hans J. Tritschler
Molecular Basis of α-Tocopherol Action and Its Protective Role Against Diabetic Complications	219	(22)
Angelo Azzi
Roberta Ricciarelli
Sophie Clement
Nesrin Ozer
Protein Kinase C Activation, Development of Diabetic Vascular Complications, and Role of Vitamin E in Preventing These Abnormalities	241	(24)
Sven-Erik Bursell
George L. King
Oxidative Stress and Pancreatic β-Cell Destruction in Insulin-Dependent Diabetes Mellitus	265	(10)
Mizuo Hotta
Eiji Yamato
Jun-ichi Miyazaki
Interrelationship Between Oxidative Stress and Insulin Resistance	275	(28)
Karen Yaworsky
Romel Somwar
Amira Klip
Oxidative Stress and Antioxidant Treatment: Effects on Muscle Glucose Transport in Animal Models of Type 1 and Type 2 Diabetes	303	(16)
Erik J. Henriksen
Oxidative Stress and Insulin Action: A Role for Antioxidants?	319	(20)
Stephan Jacob
Rainer Lehmann
Kristian Rett
Hans-Ulrich Haring
Index	339