Antiviral Therapy

by Blair, E. D.; Tisdale, M.; Gough, G.; Rowlands, D.

• ISBN13: 9780387915104
• ISBN10: 0387915109
• Format: Paperback
• Copyright: 1998-05-01
• Publisher: Bios Scientific Pub Ltd

Summary

Glaxo Wellcome Medicines Research Centre, Stevenage, U.K. A concise summary of information on drug targets and current therapy regimes for all of the major viral infections. For practitioners, health care professionals, students, and researchers. Modified outline format. Softcover. DNLM: Virus Diseases--drug therapy.

Table of Contents

Abbreviations	vii	(4)
Preface	xi
1 Development of antiviral chemotherapy	1	(20)
History: The origins of antiviral drug development	1	(1)
Early antivirals	2	(2)
The first nucleoside analogs	4	(2)
The discovery of aciclovir	6	(4)
Ganciclovir and penciclovir	10	(1)
Valaciclovir	10	(1)
Further developments in pyrimidine nucleoside analogs	11	(1)
Nucleoside analogs for the treatment of HIV infection	12	(2)
Nonnucleoside inhibitors of HIV reverse transcriptase	14	(1)
Protease inhibitors of HIV	15	(1)
Other virus infections	16	(3)
Summary	19	(2)
2 Chemotherapy of herpesvirus infections	21	(22)
Introduction: what is a herpesvirus	21	(3)
Herpes simplex virus	24	(3)
Varicella-zoster virus	27	(1)
Human cytomegalovirus	28	(1)
Epstein-Barr virus	29	(1)
Human herpes virus-6	30	(1)
Human herpes virus-7	30	(1)
Human herpes virus-8	30	(1)
History of antiviral therapy	30	(4)
Other antiherpetic agents	34	(7)
Conclusion	41	(1)
Further reading	41	(2)
3 Chemotherapy of human immunodeficiency virus infections	43	(28)
Introduction: AIDS and human immunodeficiency virus	43	(3)
HIV replication	46	(8)
RT inhibitors	54	(5)
Protease inhibitors	59	(3)
Other targets for chemotherapy	62	(4)
Novel approaches	66	(1)
Combination therapies	67	(1)
Conclusions	68	(1)
References	69	(2)
4 Chemotherapy of respiratory virus infections	71	(26)
Introduction: diversity of viruses associated with respiratory infections	71	(3)
Influenza: virus and disease	74	(3)
Influenza: antiviral drugs	77	(6)
Respiratory syncytial virus: virus and disease	83	(1)
Respiratory syncytial virus: antiviral drugs	84	(2)
Rhinoviruses: viruses and disease	86	(3)
Rhinoviruses: antiviral drugs	89	(4)
Future targets and therapies	93	(1)
References	94	(1)
Further reading	95	(2)
5 Chemotherapy of hepatitis virus infections	97	(24)
Introduction: diversity of viruses associated with hepatitis (A, B, C, D, E)	97	(3)
Likely impact of prophylaxis (vaccines, passive immunity)	100	(2)
Chronic viral hepatitis: the main target for antivirals	102	(10)
Chronic viral hepatitis: hepatitis C virus	112	(8)
References	120	(1)
6 Chemotherapy of human papillomavirus infections	121	(18)
Introduction	121	(1)
Genome organization and replication	122	(2)
Papillomavirus proteins	124	(1)
Pathobiology	125	(3)
Prevalence of HPV disease	128	(1)
Diagnosis	128	(1)
Therapy	128	(5)
Vaccines	133	(2)
Conclusions	135	(1)
References	136	(3)
7 Where next for antiviral therapies?	139	(18)
Future targets	139	(8)
Vaccines and immunomodulators	147	(7)
References	154	(3)
Index	157