Summary

A comprehensive two-volume set, the APA Handbook of Neuropsychology provides foundational information on neuropsychology, identifies pressing research questions related to neuropsychological disorders and conditions, offers updates on methods to investigate these issues, and aims to shape the field’s future development.

Volume 1, Neurobehavioral Disorders and Conditions: Accepted Science and Open Questions, aids clinicians and researchers in updating their understanding of disordered brain function and addresses questions regarding neurobehavioral disorders, such as amnesia, and clinical conditions, such as Alzheimer’s disease. Taking a lifespan approach, chapters in Volume 1 include a section on accepted neuropsychological science and a section on important issues for future research.

Volume 2, Neuroscience and Neuromethods, focuses on neuroscience, brain imaging methods, and advanced statistical models needed to investigate the questions raised in Volume 1, as well as treatment paradigms to guide future interventions. Chapters aim to stimulate innovative assessment and intervention methods.

The chapters serve as an invaluable resource for the expanding field of neuropsychology. Clinicians, researchers, students, and scholars can use this handbook to gain a foundational understanding of neuropsychology and to further advance the field themselves.

Author Biography

Gregory G. Brown, PhD, ABPP-CN, is emeritus professor, Department of Psychiatry, University of California, San Diego School of Medicine. Dr. Brown earned a PhD in psychology from Wayne State University in 1977. He worked as a clinical neuropsychologist at Henry Ford Hospital in Detroit, Michigan for 17 years and at The New York Hospital/Cornell University Medical College for a year. In 1995, he joined the Department of Psychiatry at University of California, San Diego, and the Psychology Department at the VA San Diego Healthcare System. Throughout his career he has taught courses on clinical neuropsychology and mentored trainees. Dr. Brown has 170 papers listed in ResearchGate; his neuropsychological research has been wide-ranging, involving studies of the neuropsychological functioning of patients with neurological or neuromedical disorders and studies of these patients using functional and structural brain imaging. He has a board certification from the American Board of Professional Psychology with a specialty in clinical neuropsychology, and is a fellow of Division 40 of the American Psychological Association (Society for Clinical Neuropsychology). He was the editor of the APA’s journal Neuropsychology from 2014 to 2019.

Bruce A. Crosson, PhD, ABPP-CN, has published more than 150 refereed journal articles during a career of over 40 years, and mentored 26 faculty, fellows, and graduate students. Most recently, Dr. Crosson’s primary faculty affiliations have included professor of clinical and health psychology at the University of Florida (1989–2012) and professor of neurology and of radiology and imaging sciences at Emory University (2012–2021). He held an honorary professorship in health and rehabilitation sciences at the University of Queensland in Brisbane, Australia for 18 years (2004–2021). Dr. Crosson was the recipient of a Senior Research Career Scientist Award from the VA Rehabilitation Research and Development Service (2009-2021). He is considered one of the world’s leading experts on subcortical functions in language and is also recognized for his expertise in functional neuroimaging. Dr. Crosson has held a diplomate in clinical neuropsychology from the American Board of Professional Psychology since 1986, and he is a fellow of the American Psychological Association. He was one of the organizers of the 1997 Houston Conference on Specialty Education and Training in Clinical Neuropsychology, which has guided the training of clinical neuropsychologists for more than 20 years.

Kathleen (Kathy) Y. Haaland, PhD, ABPP-CN, is a tenured professor of psychiatry and behavioral sciences at the University of New Mexico Health Sciences Center. She is board certified by the American Board of Professional Psychology and the American Board of Clinical Neuropsychology (ABPP-CN) where she continues to participate in board certification exams. She has published more than 100 papers and chapters largely focused on the cognitive and neuroanatomical correlates of action in stroke, Parkinson’s disease, and Huntington’s disease. Her research was continuously funded from 1981 to 2014, and in addition to serving as the director of neuropsychology at the New Mexico VA Healthcare System for many years, she was a VA research career scientist from 2004 to 2014. She has been recognized locally for her research, is a fellow of the American Psychological Association, and received lifetime career contribution awards from the International Neuropsychological Society and the National Academy of Neuropsychology. She has also served in leadership roles in the International Neuropsychological Society, the APA, and the American Board of Clinical Neuropsychology. She was the symposium editor and then editor in chief of the Journal of the International Neuropsychological Society. Since 2017 she has been an associate editor for the neuroscience section of Frontiers for Young Minds.

Tricia Z. King, PhD, is a tenured professor in the Department of Psychology at Georgia State University (GSU). She is a fellow of Division 40 of the American Psychological Association (Society for Clinical Neuropsychology). Dr. King earned her PhD in clinical psychology with a neuropsychology specialization at the University of Florida. Dr. King continues to investigate the interacting biopsychosocial factors that contribute to optimal outcomes following neurodevelopmental disruption. The overarching goal of her work is to contribute to advancements in precision medicine, resulting in greater prognostic abilities and enhanced interventions to mitigate neurotoxicity and enable individuals to thrive. She has published more than 100 peer reviewed papers and chapters. Dr. King is committed to diversifying the trainee pipeline and has enjoyed mentoring and training at the undergraduate and graduate level. She sponsors a chapter of the Association of Students and Trainees at GSU (SCN ANST) and was awarded the GSU Outstanding Undergraduate Mentoring Award. She has served as the chair of the SCN Scientific Advisory Board, member of the SCN Fellows Committee, and was elected Treasurer of SCN. Dr. King serves on the editorial board for Child Neuropsychology and is an associate editor of The Clinical Neuropsychologist.

Volume 1. Neurobehavioral Disorders and Conditions: Accepted Science and Open Questions

Contents

Editorial Board

About the Editors

Contributors

A Note from the Publisher

Introduction

Chapter 1. Clinical Neuropsychology: Foundational History and Future Prospects

Gregory G. Brown and Kenneth M. Adams

Part I. Neurobehavioral Disorders

Chapter 2. Word Finding and Lexical Semantic Disorders

Anastasia M. Raymer

Chapter 3. Discourse and Communicative Pragmatics

Seana Coulson, Jacob Momsen, and Crystal R. Poole

Chapter 4. The Neuropsychology of Mathematical Cognition

Konstantinos Priftis

Chapter 5. Specific Reading Disabilities

Jeremy Miciak and Jack M. Fletcher

Chapter 6. Body Representation Disorders

Liana Palermo and Antonella Di Vita

Chapter 7. Higher Order Visual Disorders

Ransom W. Campbell and Daniel Tranel

Chapter 8. Syndromes of Limb Apraxia: Developmental and Acquired Disorders of Skilled Movements

Jennifer Randerath

Chapter 9. Disorders of Executive Functioning

Yana Suchy

Chapter 10. Memory Disorders

Mieke Verfaellie and Margaret M. Keane

Part II. Clinical Conditions

Chapter 11. Spina Bifida and Other Neural Tube Defects

Victoria J. Williams, Amery Treble-Barna, Ashley L. Ware, and Jack M. Fletcher

Chapter 12. Very Preterm Birth

Alice C. Burnett

Chapter 13. Cerebral Palsy

Seth Warschausky

Chapter 14. Pediatric Brain Tumors

Michelle E. Fox and Tricia Z. King

Chapter 15. Neuropsychological Outcomes in Phenylketonuria

Cristina Romani, Lucie Thomas, and Stephan Huijbregts

Chapter 16. Neuropsychology of ADHD

Erik G. Willcutt

Chapter 17. Epilepsy and Neuropsychology

Bruce P. Hermann, David W. Loring, Stephen C. Bowden, and Rani Sarkis

Chapter 18. Traumatic Brain Injury

Andrew R. Mayer, Lindsay D. Nelson, and Erin D. Bigler

Chapter 19. Leukemia and Sickle Cell Disease

Kristina K. Hardy, Christina M. Sharkey, Hannah Weisman, and Steven Hardy

Chapter 20. Vascular Disease including Vascular Dementia

Daniel A. Nation

Chapter 21. Infectious Disorders: HIV, Hepatitis C, and COVID-19 Pandemics

Mariana Cherner, Rowan Saloner, Erin Sundermann, and David Moore

Chapter 22. Frontotemporal Dementia

Molly Memel, Joel H. Kramer, and Doris Chen

Chapter 23. Alzheimer’s Disease

Katherine J. Bangen, Lisa V. Graves, Emily C. Edmonds, Kelsey R. Thomas, and Mark W. Bondi

Chapter 24. Parkinson’s Disease and Parkinsonism: What the Field Knows

Alexander I. Tröster

Chapter 25. Huntington's Disease Across the Lifespan

Julie C. Stout

Chapter 26. Multiple Sclerosis

Michelle H. Chen, Ralph H. B. Benedict, and John DeLuca

Chapter 27. Alcohol Drinking and Alcohol Use Disorder Across the Ages: Dynamic Effects on the Brain and Function

Edith V. Sullivan, Séverine Lannoy, Anne-Pascale Le Berre, Rosemary Fama, and Adolf Pfefferbaum

Chapter 28. Neurocognitive Correlates of Psychostimulant Use

Gill Bedi, Candice Basterfield, Alex A. Guerin, Eddie Mullen, Robert Hester, and Stephen C. Bowden

Chapter 29. Marijuana

Natania A. Crane and Natasha E. Wade

Chapter 30. Prenatal Exposure to Opioids

Egil Nygaard and Jannike Mørch Andersen

Chapter 31. Environmental Toxicities Including Lead

Roberta F. White and Aaron S. Reuben

Chapter 32. Sleep and Circadian Rhythm Disorders

Sean P. A. Drummond, Melinda L. Jackson, and Jade M. Murray

Chapter 33. Autism Spectrum Disorder

Rebecca P. Thomas, Kirsty L. Coulter, and Deborah A. Fein

Chapter 34. Schizophrenia

Amy M. Jimenez and Michael F. Greene

Chapter 35. The Neuropsychology of Mood Disorders

Federica Klaus and Lisa T. Eyler

Chapter 36. The Neuropsychology of Anxiety: An Approach-Avoidance Decision-Making Framework

Robin L. Aupperle, Timothy J. McDermott, Evan White, and Namik Kirlic

Chapter 37. Eating Disorders: Anorexia Nervosa, Bulimia Nervosa, and Binge Eating Disorder

Christina E. Wierenga

Index

Volume 2. Neuroscience and Neuromethods

Contents

Editorial Board

Contributors

Part I. Neuroscience

Chapter 1. Brain Organization: From Cells and Circuits to Systems and Networks

Alex Fornito

Chapter 2. Brain Development

Clare E. Palmer and Terry L. Jernigan

Chapter 3. Behavior Genetics in Neuropsychology

William S. Kremen, Eero Vuoksimaa, and Chandra A. Reynolds

Chapter 4. Learning and Memory

Alexander J. Barnett and Charan Ranganath

Chapter 5. Movement

Brian P. Johnson and Leonardo G. Cohen

Chapter 6. Higher-Order Visual Object Representations: A Functional Analysis of Their Role in Perception and Action

Bradford Z. Mahon

Chapter 7. The Neuroscience of Language and Aphasia

Nina F. Dronkers and Maria V. Ivanova

Chapter 8. Neuroscience of Executive Functioning

Yana Suchy

Chapter 9. Social Neuroscience

Marie-Pier B. Tremblay, Carola Tuerk, Philip L. Jackson, and Miriam H. Beauchamp

Part II. Assessment: Emerging Methods

Chapter 10. Centering Social Forces and Cultural Experiences in Neuropsychological Assessment

Miguel Arce Rentería, Justina F. Avila, Jet M. J. Vonk, and Jennifer J. Manly

Chapter 11. Automated Neuropsychological Testing

Russell M. Bauer and Robert M. Bilder

Chapter 12. Wearable and Digital Technology Tools: Neuropsychological Assessment, Monitoring and Diagnosis in the Digital Era

Rhoda Au, Honghuang Lin, Kieffer Christianson, and Daniela Brunner

Chapter 13. Assessing and Predicting Everyday Function

Tania Giovannetti, Katherine Hackett, Molly B. Tassoni, Rachel Mis, and Stephanie M. Simone

Chapter 14. Evaluating social cognition

Skye McDonald and Michelle Kelly

Chapter 15. Videoconference Teleneuropsychology

Travis H. Turner and Timothy W. Brearly

Part III. Interventions

Chapter 16. Rehabilitation of Neuropsychological Deficits: The Role of Restorative Approaches

Thomas F. Bergquist, Molly J. Sullan, and Eva C. Alden

Chapter 17. Rehabilitation of Neuropsychological Deficits: Compensatory Approaches

Alyssa Weakley and Sarah Tomaszewski Farias

Chapter 18. Pediatric Rehabilitation

Shari L. Wade, Lisa M. Gies, Anna R. Adlam, Alessandra Bardoni, Claudia Corti, Kelly M. Jones, Jennifer Limond, and Tricia Williams

Chapter 19. Aphasia Treatment: Lessons for Clinically Oriented Neuroscientists

Bruce A. Crosson

Chapter 20. Interventions for Psychosocial and Emotional Sequelae of Brain Injury and Disease

Skye McDonald, Tamara Ownsworth, and Dana Wong

Chapter 21. From Virtual Reality to Augmentative Apps: The Future of Cognitive Rehabilitation Therapeutics

Anthony Y. Stringer and Anastacia Nichols

Chapter 22. Non-Invasive Brain Stimulation as a Rehabilitation Tool for Cognitive Impairment: Current Evidence, Clinical Implications, and Future Directions

Benjamin M. Hampstead, Ketrin Lengu, Elana R. Goldenkoff, and Michael Vesia

Chapter 23. Clinical Virtual Reality: The State of the Science

Albert Rizzo, Sebastian Koenig, Belinda Lange

Chapter 24. Life Style Interventions

Joe R. Nocera, Keith M. McGregor, and Monica C. Serra

Chapter 25. Implementation Science

Christopher J. Miller and Julianne E. Brady

Part IV. Neuroimaging Methods: Tutorial Presentations

Chapter 26. Structural MRI

Amanda Bischoff-Grethe and Christine Fennema-Notestine

Chapter 27. Functional and Physiological Magnetic Resonance Imaging

Frank Haist, Divya S. Bolar, and Richard B. Buxton

Chapter 28. Diffusion Imaging and Fiber Mapping

Erin D. Bigler and Naomi J. Goodrich-Hunsaker

Chapter 29. Electroencephalography in Infants and Children

Michelle Downes, Joe Bathelt, and Wanze Xie

Chapter 30. Magnetoencephalography

Carly Demopoulos

Chapter 31. PET Neuroimaging of Neurologic Disease: Methods, Clinical and Research Applications

Keenan A. Walker and Murat Bilgel

Part V. Statistical and Probabilistic Models for Neuropsychologists

Chapter 32. Formal Models of Cognition and Behavior

Gregory G. Brown

Chapter 33. Advances in Psychometric Theory: Item Response Theory, Generalizability Theory, and Cognitive Psychometrics

Michael L. Thomas and John R. Duffy

Chapter 34. Structural Equation Modeling in Neuropsychology Research

Rex B. Kline

Chapter 35. Multilevel Modeling in Neuropsychological Research

Ronald H. Heck and Tingting Reid

Chapter 36. Machine Learning

Daoqiang Zhang, Mingxia Liu, Wei Shao, Jiashuang Huang, Mingliang Wang, Liang Sun, and Meiling Wang

Index

Supplemental Materials

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