Apoptosis in Carcinogenesis and Chemotherapy

by Chen, George G.; Lai, Paul B. s.

• ISBN13: 9781402095962
• ISBN10: 1402095961
• Format: Hardcover
• Copyright: 2009-06-03
• Publisher: Springer Verlag

Summary

The purpose of this book is to provide information on apoptotic processes involved in major neoplastic diseases and their translations into emerging anti-cancer strategies. The book is divided into 15 chapters, each of which will be focused on one particular cancer (breast, bladder, cervical, colorectal, esophageal, gastric, laryngeal, liver, lung, nasopharyngeal, pancreatic, prostate, thyroid, leukaemia and cutaneous malignant melanoma). A number of established leaders in the field have critically summarized the recent discoveries concerning apoptosis in a particular cancer and its potential for anti-cancer treatment. The book describes how the apoptosis plays a role in the specific carcinogen-induced cellular and molecular changes during the development of the cancer, and critically discusses how the emerging anti-cancer strategy can be built by the utilization of the specific carcinogen-related apoptotic pathway. Therefore, this book will be not only for laboratory-based molecular and cell biologists and biochemists in cancer research but also for clinical oncologists and those working in the pharmaceutical and biotechnological industries.

Table of Contents

Apoptotic Signaling Pathway and Resistance to Apoptosis in Breast Cancer Stem Cells	p. 1
Anti-Cancer Strategy of Transitional Cell Carcinoma of Bladder Based on Induction of Different Types of Programmed Cell Deaths	p. 25
Apoptosis in Carcinogenesis and Chemoherapy of the Uterine Cervix	p. 51
Apoptosis in Colorectal Tumorigenesis and Chemotherapy	p. 75
Apoptosis in Cutaneous Melanoma	p. 111
Apoptosis in Carcinogenesis and Chemotherapy - Esophageal Cancer	p. 127
Molecular Targets in Gastric Cancer and Apoptosis	p. 157
Apoptosis and the Tumor Microenvironment in Hematologic Malignancies	p. 193
Bcl-2 Family Members in Hepatocellular Carcinoma (HCC) - Mechanisms and Therapeutic Potentials	p. 219
Apoptosis in the Development and Treatment of Laryngeal Cancer: Role of p53, Bcl-2 and Clusterin	p. 237
Cyclooxygenase 2 and its Metabolites: Implications for Lung Cancer Therapy	p. 251
Roles of Negative and Positive Growth Regulators in Nasopharyngeal Carcinoma	p. 273
Cellular Signaling Mechanisms in Pancreatic Apoptosis	p. 295
Strategies to Circumvent Resistance to Apoptosis in Prostate Cancer Cells by Targeted Necrosis	p. 327
Carcinogenesis and Therapeutic Strategies for Thyroid Cancer	p. 347
Index	p. 375
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