Apoptosis in Health and Disease

by Ruffolo, Jr.; Robert R.

• ISBN13: 9789058230867
• ISBN10: 9058230864
• Format: Hardcover
• Copyright: 2000-09-15
• Publisher: CRC Press

Summary

The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation and organ remodelling. It is hoped that, with an increase in our understanding of the mechanisms controlling apoptosis, there will come the development of a new class of drugs which can pharmacologically manipulate apoptosis and thus provide a means to treat important diseases which currently pose problems to our society.Containing papers presented at the Eleventh SmithKline Beecham Pharmaceuticals United States Research Symposium and with contributions from leading researchers, Apoptosis in Health and Disease offers a comprehensive review of important developments and research in the field.

Table of Contents

Preface to the Series	ix
Preface to the Volume	xi
Contributors	xiii
Caspase Activation in the Cardiomyocyte: A Drug Discovery Perspective	1	(16)
Lawrence C. Fritz
Joe Wu
Anu Srinivasan
Kevin J. Tomaselli
Robert C. Armstrong
Apoptosis and Autoimmune Diseases	17	(16)
Peter M. Lydyard
Pierre Y. Youinou
David A. Isenberg
Ischemic Neuronal Death is not by Classic Apoptosis: Are all DNA-ladders the Same?	33	(14)
John P. MacManus
Ingrid Rasquinha
The Role of Caspases in Apoptosis In Vivo Studied by Gene Targeting	47	(14)
Richard A. Flavell
Keisuke Kuida
Timothy S. Zheng
Tarik F. Haydar
Chia-Yi Kuan
Michael S. Su
Pasco Rakic
Why Atherosclerotic Vessels Narrow and Re-narrow	61	(24)
Karen O. Yee
Stephen M. Schwartz
Death-associated Proteins: From Gene Identification to the Analysis of Their Apoptotic and Tumor-Suppressive Functions	85	(18)
Adi Kimchi
Abortive Apoptosis as a Mechanism for Resistance to Cancer Therapy	103	(12)
Edward P. Gelmann
Cai Bowen
Kotohiko Kimura
Apoptosis in Cardiac Diseases: New Opportunities for Novel Therapeutics for Heart Diseases	115	(10)
Giora Z. Feuerstein
Pharmacological Regulation of Vascular Smooth Muscle Cell Apoptosis In Vivo	125	(24)
Denis deBlois
Pierre Moreau
Bun-Seng Tea
Johanne Tremblay
Pavel Hamet
Pathways of Neuronal Apoptosis	149	(16)
David S. Park
Caspase Activation Pathways in Neuronal Death in Stroke	165	(8)
Michael A. Moskowitz
Turgay Dalkara
The Role of Caspases in Cell Death After Brain Ischemia	173	(10)
Julie A. Ellison
James J. Velier
Giora Z. Feuerstein
Yeast as a Model Organism for Studying Apoptosis	183	(12)
Jason J. Kang
Hossein Askari
David J. Hall
Mary-Ann Bjornsti
Regulation of Programmed Cell Death and Viral Pathogenesis by the Bcl-2 Protein Family and Caspases	195	(20)
J. Marie Hardwick
Jennifer Lewis
Shifa Zou
Emily H.-Y. Cheng
David G. Kirsch
David S. Bellows
Nelson Chau
George A. Oyler
Kazuyoshi Ueno
Jun Zhang
Rollie J. Clem
Death Paradigms in Cellular Hypoxia	215	(30)
Pothana Saikumar
Zheng Dong
Michael Denton
Joel M. Weinberg
M.A. Venkatachalam
Index	245